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Tchem
ATP12A
Potassium-transporting ATPase alpha chain 2

Protein Summary
Description
Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for potassium absorption in various tissues. The protein encoded by this gene belongs to the family of P-type cation transport ATPases. This gene encodes a catalytic subunit of the ouabain-sensitive H+/K+ -ATPase that catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. It is also responsible for potassium absorption in various tissues. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000218548
  • ENSP00000218548
  • ENSG00000075673
  • ENST00000381946
  • ENSP00000371372

Symbol
  • ATP1AL1
  • HK
  • ATP1AL1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
protein domain
1
gene perturbation
0.67
PubMedID
0.66
cellular component
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11122.34   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 123   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11122.34   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 123   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 10
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (10)
CHEMBL2068911
Rendered image for CHEMBL2068911
CHEMBL2068890
Rendered image for CHEMBL2068890
CHEMBL1453
Rendered image for CHEMBL1453
CHEMBL323301
Rendered image for CHEMBL323301
CHEMBL104027
Rendered image for CHEMBL104027
CHEMBL318786
Rendered image for CHEMBL318786
CHEMBL319670
Rendered image for CHEMBL319670
CHEMBL2093999
Rendered image for CHEMBL2093999
CHEMBL321090
Rendered image for CHEMBL321090
CHEMBL2068917
Rendered image for CHEMBL2068917
Protein-Protein Interactions (216)
ATP1B3
Tclin
Family:  Transporter
Novelty:  0.06773518
p_int:  0.995225141
p_ni:  0.004774859
Score:  0.843
Data Source:  BioPlex,STRINGDB
FXYD6
Tbio
Family:  IC
Novelty:  0.0503209
p_int:  0.990399955
p_ni:  0.009600045
Data Source:  BioPlex
TNFRSF10C
Tbio
Novelty:  0.0088942
p_int:  0.987623754
p_ni:  0.012376246
Data Source:  BioPlex
ART3
Tbio
Family:  Enzyme
Novelty:  0.02783085
p_int:  0.984380962
p_ni:  0.015619035
p_wrong:  3e-9
Score:  0.152
Data Source:  BioPlex,STRINGDB
TRARG1
Tbio
Novelty:  0.07729433
p_int:  0.980613323
p_ni:  0.019386676
Data Source:  BioPlex
TIMM23
Tbio
Family:  Enzyme
Novelty:  0.06463808
p_int:  0.979089217
p_ni:  0.020910782
p_wrong:  1e-9
Data Source:  BioPlex
LAGE3
Tdark
Novelty:  0.02099961
p_int:  0.976223299
p_ni:  0.023776701
Data Source:  BioPlex
UPK2
Tbio
Novelty:  0.01066132
p_int:  0.976180959
p_ni:  0.023819041
Data Source:  BioPlex
SLC2A5
Tbio
Family:  Transporter
Novelty:  0.0032733
p_int:  0.975421714
p_ni:  0.024578286
Score:  0.181
Data Source:  BioPlex,STRINGDB
CCR6
Tchem
Family:  GPCR
Novelty:  0.00257933
p_int:  0.972204828
p_ni:  0.027795172
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Ion channel transport (R-HSA-983712)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Ion channel transport
Reactome
Ion transport by P-type ATPases
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Ion channel transport
Ion transport by P-type ATPases
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (13)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
1
1
1
46.9
cystic fibrosis associated meconium ileus
1
1
0
1.6
39.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
1
46.9
cystic fibrosis associated meconium ileus
0
1.6
39.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ATPase H+/K+ transporting non-gastric alpha2 subunit
VGNC:7826
452489
Macaque
ATPase H+/K+ transporting non-gastric alpha2 subunit
721488
Mouse
MGI:1926943
192113
Rat
RGD:620569
171028
Dog
ATPase H+/K+ transporting non-gastric alpha2 subunit
VGNC:38240
403820
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ATPase H+/K+ transporting non-gastric alpha2 subunit
Macaque
ATPase H+/K+ transporting non-gastric alpha2 subunit
Mouse
Rat
Dog
ATPase H+/K+ transporting non-gastric alpha2 subunit
Publication Statistics
PubMed Score 11122.34
PubMed score by year
PubTator Score 108.50
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title