ATP12A
Potassium-transporting ATPase alpha chain 2
Protein Summary
Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for potassium absorption in various tissues. The protein encoded by this gene belongs to the family of P-type cation transport ATPases. This gene encodes a catalytic subunit of the ouabain-sensitive H+/K+ -ATPase that catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. It is also responsible for potassium absorption in various tissues. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
- ENST00000218548
- ENSP00000218548
- ENSG00000075673
- ENST00000381946
- ENSP00000371372
- ATP1AL1
- HK
- ATP1AL1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 1 | ||
protein domain | 1 | ||
gene perturbation | 0.67 | ||
PubMedID | 0.66 | ||
cellular component | 0.63 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 11122.34 (req: < 5)
Gene RIFs: 12 (req: <= 3)
Antibodies: 123 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 11122.34 (req: >= 5)
Gene RIFs: 12 (req: > 3)
Antibodies: 123 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 10
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (10)
Protein-Protein Interactions (216)
ATP1B3
Family: Transporter
Novelty: 0.06773518
p_int: 0.995225141
p_ni: 0.004774859
Score: 0.843
Data Source: BioPlex,STRINGDB
ART3
Family: Enzyme
Novelty: 0.02783085
p_int: 0.984380962
p_ni: 0.015619035
p_wrong: 3e-9
Score: 0.152
Data Source: BioPlex,STRINGDB
TIMM23
Family: Enzyme
Novelty: 0.06463808
p_int: 0.979089217
p_ni: 0.020910782
p_wrong: 1e-9
Data Source: BioPlex
SLC2A5
Family: Transporter
Novelty: 0.0032733
p_int: 0.975421714
p_ni: 0.024578286
Score: 0.181
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (5)
Reactome (3)
KEGG (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Ion channel transport | ||||
Reactome | Ion transport by P-type ATPases | ||||
Reactome | Transport of small molecules | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Ion channel transport | ||||
Ion transport by P-type ATPases | ||||
Transport of small molecules | ||||
Viral Interactions (0)
Gene Ontology Terms (13)
Functions (4)
Components (3)
Processes (6)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
diastolic blood pressure | 1 | 1 | 1 | 46.9 | |||||
cystic fibrosis associated meconium ileus | 1 | 1 | 0 | 1.6 | 39.6 | ||||
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
diastolic blood pressure | 1 | 46.9 | |||||
cystic fibrosis associated meconium ileus | 0 | 1.6 | 39.6 | ||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | ATPase H+/K+ transporting non-gastric alpha2 subunit | VGNC:7826 | 452489 | |||||
Macaque | ATPase H+/K+ transporting non-gastric alpha2 subunit | 721488 | ||||||
Mouse | MGI:1926943 | 192113 | ||||||
Rat | RGD:620569 | 171028 | ||||||
Dog | ATPase H+/K+ transporting non-gastric alpha2 subunit | VGNC:38240 | 403820 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | ATPase H+/K+ transporting non-gastric alpha2 subunit | |||||
Macaque | ATPase H+/K+ transporting non-gastric alpha2 subunit | |||||
Mouse | ||||||
Rat | ||||||
Dog | ATPase H+/K+ transporting non-gastric alpha2 subunit | |||||
Publication Statistics
PubMed Score 11122.34
PubMed score by year
PubTator Score 108.50
PubTator score by year
Related Publications
Text Mined References (25)
GeneRif Annotations (12)
Items per page:
0 of 0
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