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Tbio
ATP11C
Phospholipid-transporting ATPase IG

Protein Summary
Description
Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. In the cell membrane of erythrocytes, it is required to maintain phosphatidylserine (PS) in the inner leaflet preventing its exposure on the surface. This asymmetric distribution is critical for the survival of erythrocytes in circulation since externalized PS is a phagocytic signal for splenic macrophages (PubMed:26944472). Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (By similarity). Required for B cell differentiation past the pro-B cell stage (By similarity). Seems to mediate PS flipping in pro-B cells (By similarity). May be involved in the transport of cholestatic bile acids (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000327569
  • ENSP00000332756
  • ENSG00000101974
  • ENST00000361648
  • ENSP00000355165

Symbol
  • ATPIG
  • ATPIQ
  • ATPIG
  • ATPIQ
  • HACXL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
metabolite
0.98
protein domain
0.92
phenotype
0.76
microRNA
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.73   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 95   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.73   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 95   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (74)
MBLAC2
Tdark
Family:  Enzyme
Novelty:  0.47407992
p_int:  0.999938015
p_ni:  0.000061985
Score:  0.15
Data Source:  BioPlex,STRINGDB
TNFRSF10C
Tbio
Novelty:  0.0088942
p_int:  0.999739517
p_ni:  0.000260483
Data Source:  BioPlex
NKAIN1
Tdark
Family:  Enzyme
Novelty:  0.52190272
p_int:  0.998754544
p_ni:  0.001245456
Data Source:  BioPlex
MTUS2
Tbio
Novelty:  0.13504593
p_int:  0.998488127
p_ni:  0.001511873
Data Source:  BioPlex
SLC22A2
Tchem
Family:  Transporter
Novelty:  0.00439263
p_int:  0.996907112
p_ni:  0.003092883
p_wrong:  5e-9
Data Source:  BioPlex
NRN1
Tbio
Novelty:  0.01198116
p_int:  0.9948281
p_ni:  0.0051719
Data Source:  BioPlex
GPR21
Tdark
Family:  GPCR
Novelty:  0.90865557
p_int:  0.989267009
p_ni:  0.010732991
Data Source:  BioPlex
P2RY1
Tchem
Family:  GPCR
Novelty:  0.00203299
p_int:  0.988197241
p_ni:  0.011802759
Score:  0.179
Data Source:  BioPlex,STRINGDB
MUC1
Tchem
Novelty:  0.00024203
p_int:  0.986544526
p_ni:  0.013455474
Score:  0.18
Data Source:  BioPlex,STRINGDB
LRRC55
Tbio
Family:  IC
Novelty:  0.25121277
p_int:  0.985957169
p_ni:  0.014042831
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Ion channel transport (R-HSA-983712)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Ion channel transport
Reactome
Ion transport by P-type ATPases
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Ion channel transport
Ion transport by P-type ATPases
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
1
1
1
47.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
1
47.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ATPase phospholipid transporting 11C
VGNC:7635
465889
Macaque
ATPase phospholipid transporting 11C
695802
Mouse
MGI:1859661
320940
Rat
RGD:1564481
317599
Dog
ATPase phospholipid transporting 11C
VGNC:38239
481066
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ATPase phospholipid transporting 11C
Macaque
ATPase phospholipid transporting 11C
Mouse
Rat
Dog
ATPase phospholipid transporting 11C
Publication Statistics
PubMed Score 20.73
PubMed score by year
PubTator Score 6.66
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title