You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
ATP11A
Probable phospholipid-transporting ATPase IH

Protein Summary
Description
Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable). May be involved in the uptake of farnesyltransferase inhibitor drugs, such as lonafarnib. The protein encoded by this gene is an integral membrane ATPase. The encoded protein is probably phosphorylated in its intermediate state and likely drives the transport of ions such as calcium across membranes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375645
  • ENSP00000364796
  • ENSG00000068650
  • ENST00000487903
  • ENSP00000420387

Symbol
  • ATPIH
  • ATPIS
  • KIAA1021
  • ATPIH
  • ATPIS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
metabolite
0.98
protein domain
0.92
cellular component
0.89
virus perturbation
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.28   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 54   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.28   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 54   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (179)
NPDC1
Tbio
Novelty:  0.05766647
p_int:  0.999999998
p_ni:  2e-9
Score:  0.403
Data Source:  BioPlex,STRINGDB
PICK1
Tbio
Novelty:  0.0058265
p_int:  0.994257491
p_ni:  0.00001458
p_wrong:  0.005727929
Score:  0.187
Data Source:  BioPlex,STRINGDB
TMEM30A
Tbio
Novelty:  0.05115559
Score:  0.977
Data Source:  STRINGDB
MGAM
Tclin
Family:  Enzyme
Novelty:  0.00045865
Score:  0.97
Data Source:  STRINGDB
ATP6V0C
Tbio
Family:  Enzyme
Novelty:  0.01142874
Score:  0.945
Data Source:  STRINGDB
ATP6AP2
Tbio
Novelty:  0.00357665
Score:  0.933
Data Source:  STRINGDB
SLC11A1
Tbio
Family:  Transporter
Novelty:  0.00121416
Score:  0.931
Data Source:  STRINGDB
ATP6V1D
Tbio
Family:  Enzyme
Novelty:  0.02298626
Score:  0.923
Data Source:  STRINGDB
COPB1
Tbio
Novelty:  0.0078407
Score:  0.914
Data Source:  STRINGDB
STOM
Tbio
Novelty:  0.00459891
Score:  0.913
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (28)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Ion channel transport
Reactome
Ion transport by P-type ATPases
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Ion channel transport
Ion transport by P-type ATPases
Neutrophil degranulation
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
4
6
6
97.6
red blood cell distribution width
4
3
6
97.5
reticulocyte measurement
2
2
4
80
red blood cell density measurement
1
1
1
68.6
suntan
1
1
1
67.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
6
97.6
red blood cell distribution width
6
97.5
reticulocyte measurement
4
80
red blood cell density measurement
1
68.6
suntan
1
67.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
ATPase phospholipid transporting 11A
712589
Mouse
MGI:1354735
50770
Rat
RGD:1308688
306600
Dog
ATPase phospholipid transporting 11A
VGNC:38238
476992
Horse
ATPase phospholipid transporting 11A
VGNC:15636
100066940
Species
Name
OMA
EggNOG
Inparanoid
Macaque
ATPase phospholipid transporting 11A
Mouse
Rat
Dog
ATPase phospholipid transporting 11A
Horse
ATPase phospholipid transporting 11A
Publication Statistics
PubMed Score 21.28
PubMed score by year
PubTator Score 6.08
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title