ATP11A
Probable phospholipid-transporting ATPase IH
Protein Summary
Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable). May be involved in the uptake of farnesyltransferase inhibitor drugs, such as lonafarnib. The protein encoded by this gene is an integral membrane ATPase. The encoded protein is probably phosphorylated in its intermediate state and likely drives the transport of ions such as calcium across membranes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
- ENST00000375645
- ENSP00000364796
- ENSG00000068650
- ENST00000487903
- ENSP00000420387
- ATPIH
- ATPIS
- KIAA1021
- ATPIH
- ATPIS
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.99 | ||
metabolite | 0.98 | ||
protein domain | 0.92 | ||
cellular component | 0.89 | ||
virus perturbation | 0.85 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 21.28 (req: < 5)
Gene RIFs: 4 (req: <= 3)
Antibodies: 54 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 21.28 (req: >= 5)
Gene RIFs: 4 (req: > 3)
Antibodies: 54 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (179)
Nearest Tclin Targets
Pathways (28)
Reactome (6)
WikiPathways (22)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Immune System | ||||
Reactome | Innate Immune System | ||||
Reactome | Ion channel transport | ||||
Reactome | Ion transport by P-type ATPases | ||||
Reactome | Neutrophil degranulation | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Immune System | ||||
Innate Immune System | ||||
Ion channel transport | ||||
Ion transport by P-type ATPases | ||||
Neutrophil degranulation | ||||
Viral Interactions (0)
Gene Ontology Terms (16)
Functions (3)
Components (11)
Processes (2)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations (null)
GWAS Traits (14)
Items per page:
1 – 5 of 14
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
HbA1c measurement | 4 | 6 | 6 | 97.6 | |||||
red blood cell distribution width | 4 | 3 | 6 | 97.5 | |||||
reticulocyte measurement | 2 | 2 | 4 | 80 | |||||
red blood cell density measurement | 1 | 1 | 1 | 68.6 | |||||
suntan | 1 | 1 | 1 | 67.1 | |||||
Items per page:
1 – 5 of 14
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
HbA1c measurement | 6 | 97.6 | |||||
red blood cell distribution width | 6 | 97.5 | |||||
reticulocyte measurement | 4 | 80 | |||||
red blood cell density measurement | 1 | 68.6 | |||||
suntan | 1 | 67.1 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | ATPase phospholipid transporting 11A | 712589 | ||||||
Mouse | MGI:1354735 | 50770 | ||||||
Rat | RGD:1308688 | 306600 | ||||||
Dog | ATPase phospholipid transporting 11A | VGNC:38238 | 476992 | |||||
Horse | ATPase phospholipid transporting 11A | VGNC:15636 | 100066940 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | ATPase phospholipid transporting 11A | |||||
Mouse | ||||||
Rat | ||||||
Dog | ATPase phospholipid transporting 11A | |||||
Horse | ATPase phospholipid transporting 11A | |||||
Publication Statistics
PubMed Score 21.28
PubMed score by year
PubTator Score 6.08
PubTator score by year
Related Publications
Text Mined References (16)
GeneRif Annotations (4)
Items per page:
0 of 0
PMID | Year | Title |
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