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Tbio
ATOX1
Copper transport protein ATOX1

Protein Summary
Description
Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense. This gene encodes a copper chaperone that plays a role in copper homeostasis by binding and transporting cytosolic copper to ATPase proteins in the trans-Golgi network for later incorporation to the ceruloplasmin. This protein also functions as an antioxidant against superoxide and hydrogen peroxide, and therefore, may play a significant role in cancer carcinogenesis. Because of its cytogenetic location, this gene represents a candidate gene for 5q-syndrome. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000313115
  • ENSP00000316854
  • ENSG00000177556
  • ENST00000522710
  • ENSP00000429814
  • ENST00000524142
  • ENSP00000430598

Symbol
  • HAH1
  • ATX1
  • HAH1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.97
kinase perturbation
0.95
disease perturbation
0.87
histone modification site profile
0.78
molecular function
0.73


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 221.78   (req: < 5)
Gene RIFs: 56   (req: <= 3)
Antibodies: 212   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 221.78   (req: >= 5)
Gene RIFs: 56   (req: > 3)
Antibodies: 212   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (75)
ATP7A
Tbio
Family:  Enzyme
Novelty:  0.00064155
Score:  0.999
Data Source:  Reactome,STRINGDB
SOD3
Tbio
Family:  Enzyme
Novelty:  0.0015758
Score:  0.986
Data Source:  STRINGDB
ATP7B
Tbio
Family:  Enzyme
Novelty:  0.00115807
Score:  0.984
Data Source:  STRINGDB
CCS
Tbio
Family:  Enzyme
Novelty:  0.01379006
Score:  0.979
Data Source:  STRINGDB
COX17
Tbio
Family:  Enzyme
Novelty:  0.01025112
Score:  0.94
Data Source:  STRINGDB
PDZD11
Tbio
Novelty:  0.09750858
Score:  0.905
Data Source:  Reactome,STRINGDB
SOD1
Tchem
Family:  Enzyme
Novelty:  0.00039653
Score:  0.895
Data Source:  STRINGDB
SLC31A1
Tbio
Family:  Transporter
Novelty:  0.00658529
Score:  0.876
Data Source:  STRINGDB
COX11
Tbio
Family:  Enzyme
Novelty:  0.02572582
Score:  0.858
Data Source:  STRINGDB
SLC31A2
Tbio
Family:  Transporter
Novelty:  0.00979569
Score:  0.845
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (9)
Antimicrobial peptides (R-HSA-6803157)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antimicrobial peptides
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Detoxification of Reactive Oxygen Species
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Antimicrobial peptides
Cellular responses to external stimuli
Cellular responses to stress
Detoxification of Reactive Oxygen Species
Immune System
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
1
1
48.5
red blood cell distribution width
1
1
1
42.3
systolic blood pressure change measurement
1
1
1
24.5
creatinine measurement
1
1
1
8
glomerular filtration rate
1
1
1
3.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
48.5
red blood cell distribution width
1
42.3
systolic blood pressure change measurement
1
24.5
creatinine measurement
1
8
glomerular filtration rate
1
3.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
antioxidant 1 copper chaperone
VGNC:3908
743743
Macaque
antioxidant 1 copper chaperone
712464
Mouse
MGI:1333855
11927
Rat
RGD:621684
84355
Dog
antioxidant 1 copper chaperone
VGNC:38237
403713
Species
Name
OMA
EggNOG
Inparanoid
Chimp
antioxidant 1 copper chaperone
Macaque
antioxidant 1 copper chaperone
Mouse
Rat
Dog
antioxidant 1 copper chaperone
Publication Statistics
PubMed Score 221.78
PubMed score by year
PubTator Score 135.62
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title