Protein Summary
Transcriptional corepressor. Recruits NR2E1 to repress transcription. Promotes vascular smooth cell (VSMC) migration and orientation (By similarity). Corepressor of MTG8 transcriptional repression. Has some intrinsic repression activity which is independent of the number of poly-Gln (polyQ) repeats. Dentatorubral pallidoluysian atrophy (DRPLA) is a rare neurodegenerative disorder characterized by cerebellar ataxia, myoclonic epilepsy, choreoathetosis, and dementia. The disorder is related to the expansion from 7-35 copies to 49-93 copies of a trinucleotide repeat (CAG/CAA) within this gene. The encoded protein includes a serine repeat and a region of alternating acidic and basic amino acids, as well as the variable glutamine repeat. Alternative splicing results in two transcripts variants that encode the same protein. [provided by RefSeq, Jul 2016]
- ENST00000356654
- ENSP00000349076
- ENSG00000111676
- ENST00000396684
- ENSP00000379915
- D12S755E
- DRPLA
- B37
- HRS
- NOD
- DRPLA
- D12S755E
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor | 0.86 | ||
hub protein | 0.85 | ||
transcription factor binding site profile | 0.76 | ||
cell line | 0.72 | ||
kinase | 0.69 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 77.07 (req: < 5)
Gene RIFs: 27 (req: <= 3)
Antibodies: 135 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 77.07 (req: >= 5)
Gene RIFs: 27 (req: > 3)
Antibodies: 135 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (143)
WDR5
Novelty: 0.0059945
p_int: 0.999999998
p_wrong: 2e-9
Score: 0.273
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (5)
Reactome (5)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Intracellular signaling by second messengers | ||||
Reactome | PIP3 activates AKT signaling | ||||
Reactome | PTEN Regulation | ||||
Reactome | Regulation of PTEN gene transcription | ||||
Reactome | Signal Transduction | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Intracellular signaling by second messengers | ||||
PIP3 activates AKT signaling | ||||
PTEN Regulation | ||||
Regulation of PTEN gene transcription | ||||
Signal Transduction | ||||
Viral Interactions (0)
Gene Ontology Terms (13)
Functions (4)
Components (6)
Processes (3)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations (null)
GWAS Traits (19)
Items per page:
1 – 5 of 19
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
oleic acid measurement | 2 | 3 | 3 | 95.7 | |||||
docosapentaenoic acid measurement | 1 | 2 | 2 | 92.8 | |||||
fatty acid measurement | 1 | 2 | 2 | 92.8 | |||||
linolenic acid measurement | 1 | 2 | 2 | 92.8 | |||||
arachidonic acid measurement | 1 | 2 | 2 | 92.8 | |||||
Items per page:
1 – 5 of 19
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
oleic acid measurement | 3 | 95.7 | |||||
docosapentaenoic acid measurement | 2 | 92.8 | |||||
fatty acid measurement | 2 | 92.8 | |||||
linolenic acid measurement | 2 | 92.8 | |||||
arachidonic acid measurement | 2 | 92.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | atrophin 1 | 722114 | ||||||
Mouse | MGI:104725 | 13498 | ||||||
Rat | RGD:6491795 | 100911672 | ||||||
Dog | atrophin 1 | VGNC:38234 | 611607 | |||||
Horse | atrophin 1 [Source:HGNC Symbol;Acc:HGNC:3033] | |||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | atrophin 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | atrophin 1 | |||||
Horse | atrophin 1 [Source:HGNC Symbol;Acc:HGNC:3033] | |||||
Publication Statistics
PubMed Score 77.07
PubMed score by year
PubTator Score 649.69
PubTator score by year
Related Publications
Text Mined References (65)
GeneRif Annotations (27)
Items per page:
0 of 0
PMID | Year | Title |
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