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Tbio
ATN1
Atrophin-1

Protein Summary
Description
Transcriptional corepressor. Recruits NR2E1 to repress transcription. Promotes vascular smooth cell (VSMC) migration and orientation (By similarity). Corepressor of MTG8 transcriptional repression. Has some intrinsic repression activity which is independent of the number of poly-Gln (polyQ) repeats. Dentatorubral pallidoluysian atrophy (DRPLA) is a rare neurodegenerative disorder characterized by cerebellar ataxia, myoclonic epilepsy, choreoathetosis, and dementia. The disorder is related to the expansion from 7-35 copies to 49-93 copies of a trinucleotide repeat (CAG/CAA) within this gene. The encoded protein includes a serine repeat and a region of alternating acidic and basic amino acids, as well as the variable glutamine repeat. Alternative splicing results in two transcripts variants that encode the same protein. [provided by RefSeq, Jul 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000356654
  • ENSP00000349076
  • ENSG00000111676
  • ENST00000396684
  • ENSP00000379915

Symbol
  • D12S755E
  • DRPLA
  • B37
  • HRS
  • NOD
  • DRPLA
  • D12S755E
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor
0.86
hub protein
0.85
transcription factor binding site profile
0.76
cell line
0.72
kinase
0.69


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.07   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 135   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.07   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 135   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (143)
WDR5
Tchem
Novelty:  0.0059945
p_int:  0.999999998
p_wrong:  2e-9
Score:  0.273
Data Source:  BioPlex,STRINGDB
NR2E1
Tbio
Family:  NR
Novelty:  0.0184868
Score:  0.98
Data Source:  STRINGDB
JUN
Tchem
Family:  TF
Novelty:  0.00006856
Score:  0.951
Data Source:  STRINGDB
KDM1A
Tchem
Family:  Epigenetic
Novelty:  0.00142673
Score:  0.946
Data Source:  STRINGDB
HDAC3
Tclin
Family:  Epigenetic
Novelty:  0.00393172
Score:  0.937
Data Source:  STRINGDB
SALL4
Tbio
Family:  TF
Novelty:  0.00354374
Score:  0.934
Data Source:  STRINGDB
PPARG
Tclin
Family:  NR
Novelty:  0.00010033
Score:  0.926
Data Source:  STRINGDB
PHC1
Tbio
Novelty:  0.01530622
Score:  0.926
Data Source:  STRINGDB
HDAC1
Tclin
Family:  Epigenetic
Novelty:  0.00065244
Score:  0.924
Data Source:  STRINGDB
REST
Tbio
Family:  TF
Novelty:  0.00260619
Score:  0.924
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Intracellular signaling by second messengers (R-HSA-9006925)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Intracellular signaling by second messengers
Reactome
PIP3 activates AKT signaling
Reactome
PTEN Regulation
Reactome
Regulation of PTEN gene transcription
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Intracellular signaling by second messengers
PIP3 activates AKT signaling
PTEN Regulation
Regulation of PTEN gene transcription
Signal Transduction
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (13)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
oleic acid measurement
2
3
3
95.7
docosapentaenoic acid measurement
1
2
2
92.8
fatty acid measurement
1
2
2
92.8
linolenic acid measurement
1
2
2
92.8
arachidonic acid measurement
1
2
2
92.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
oleic acid measurement
3
95.7
docosapentaenoic acid measurement
2
92.8
fatty acid measurement
2
92.8
linolenic acid measurement
2
92.8
arachidonic acid measurement
2
92.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
atrophin 1
722114
Mouse
MGI:104725
13498
Rat
RGD:6491795
100911672
Dog
atrophin 1
VGNC:38234
611607
Horse
atrophin 1 [Source:HGNC Symbol;Acc:HGNC:3033]
Species
Name
OMA
EggNOG
Inparanoid
Macaque
atrophin 1
Mouse
Rat
Dog
atrophin 1
Horse
atrophin 1 [Source:HGNC Symbol;Acc:HGNC:3033]
Publication Statistics
PubMed Score 77.07
PubMed score by year
PubTator Score 649.69
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title