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Tbio
ATL2
Atlastin-2

Protein Summary
Description
GTPase tethering membranes through formation of trans-homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis (PubMed:18270207, PubMed:19665976, PubMed:27619977).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000378954
  • ENSP00000368237
  • ENSG00000119787
  • ENST00000402054
  • ENSP00000384062
  • ENST00000419554
  • ENSP00000415336
  • ENST00000452935
  • ENSP00000390743

Symbol
  • ARL6IP2
  • aip-2
  • ARL3IP2
  • ARL6IP2
  • atlastin2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.94
molecular function
0.93
microRNA
0.78
small molecule perturbation
0.75
histone modification site profile
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.66   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 113   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.66   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 113   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0