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Tbio
ATL2
Atlastin-2

Protein Summary
Description
GTPase tethering membranes through formation of trans-homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis (PubMed:18270207, PubMed:19665976, PubMed:27619977).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000378954
  • ENSP00000368237
  • ENSG00000119787
  • ENST00000402054
  • ENSP00000384062
  • ENST00000419554
  • ENSP00000415336
  • ENST00000452935
  • ENSP00000390743

Symbol
  • ARL6IP2
  • aip-2
  • ARL3IP2
  • ARL6IP2
  • atlastin2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.94
molecular function
0.93
microRNA
0.78
small molecule perturbation
0.75
histone modification site profile
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.71   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 113   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.71   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 113   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (51)
RGL1
Tbio
Novelty:  0.0095933
p_int:  0.999944819
p_ni:  0.000055176
p_wrong:  4e-9
Data Source:  BioPlex
TACR3
Tchem
Family:  GPCR
Novelty:  0.00351352
p_int:  0.989384067
p_ni:  0.010444323
p_wrong:  0.00017161
Data Source:  BioPlex
COPG1
Tbio
Novelty:  0.01331193
p_int:  0.984599071
p_ni:  0.015400929
Score:  0.161
Data Source:  BioPlex,STRINGDB
P2RY8
Tbio
Family:  GPCR
Novelty:  0.05574297
p_int:  0.976501379
p_ni:  0.023498621
Score:  0.188
Data Source:  BioPlex,STRINGDB
CMKLR1
Tchem
Family:  GPCR
Novelty:  0.00893083
p_int:  0.957502114
p_ni:  0.038904172
p_wrong:  0.003593714
Data Source:  BioPlex
PTCHD3
Tbio
Novelty:  0.00081643
p_int:  0.931938217
p_ni:  0.064373249
p_wrong:  0.003688534
Data Source:  BioPlex
SLC2A12
Tbio
Family:  Transporter
Novelty:  0.01455533
p_int:  0.930991095
p_ni:  0.069008643
p_wrong:  2.62e-7
Data Source:  BioPlex
MAS1
Tchem
Family:  GPCR
Novelty:  0.0089712
p_int:  0.924370272
p_ni:  0.075627523
p_wrong:  0.000002205
Data Source:  BioPlex
C5AR2
Tbio
Family:  GPCR
Novelty:  0.01193736
p_int:  0.923492198
p_ni:  0.076507344
p_wrong:  4.58e-7
Data Source:  BioPlex
IL1R2
Tbio
Novelty:  0.00820359
p_int:  0.917174331
p_ni:  0.071075894
p_wrong:  0.011749775
Score:  0.165
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
atlastin GTPase 2
VGNC:19
459164
Macaque
atlastin GTPase 2
710647
Mouse
MGI:1929492
56298
Rat
RGD:1305125
298757
Dog
atlastin GTPase 2
VGNC:38231
100856650
Species
Name
OMA
EggNOG
Inparanoid
Chimp
atlastin GTPase 2
Macaque
atlastin GTPase 2
Mouse
Rat
Dog
atlastin GTPase 2
Publication Statistics
PubMed Score 26.71
PubMed score by year
PubTator Score 11.05
PubTator score by year
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Related Publications
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PMID
Year
Title