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Tchem
ATIC
Bifunctional purine biosynthesis protein PURH

Protein Summary
Description
Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis. Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization (PubMed:25687571). This gene encodes a bifunctional protein that catalyzes the last two steps of the de novo purine biosynthetic pathway. The N-terminal domain has phosphoribosylaminoimidazolecarboxamide formyltransferase activity, and the C-terminal domain has IMP cyclohydrolase activity. A mutation in this gene results in AICA-ribosiduria. [provided by RefSeq, Sep 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000236959
  • ENSP00000236959
  • ENSG00000138363
  • ENST00000435675
  • ENSP00000415935

Symbol
  • PURH
  • PURH
  • AICAR
  • AICARFT
  • IMPCHASE
  • HEL-S-70p
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.88
disease perturbation
0.83
interacting protein
0.83
transcription factor binding site profile
0.82
kinase perturbation
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 215.85   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 367   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 215.85   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 367   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 23
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (288)
GART
Tclin
Novelty:  0.00524985
Score:  0.999
Data Source:  STRINGDB
ADSL
Tbio
Family:  Enzyme
Novelty:  0.0028496
Score:  0.998
Data Source:  STRINGDB
SHMT1
Tbio
Family:  Enzyme
Novelty:  0.00200739
Score:  0.995
Data Source:  STRINGDB
PAICS
Tchem
Novelty:  0.00215277
Score:  0.994
Data Source:  STRINGDB
SHMT2
Tchem
Family:  Enzyme
Novelty:  0.00234505
Score:  0.993
Data Source:  STRINGDB
MTHFD1
Tchem
Family:  Enzyme
Novelty:  0.0071938
Score:  0.987
Data Source:  STRINGDB
ADSS
Tchem
Family:  Enzyme
Novelty:  0.0126472
Score:  0.983
Data Source:  STRINGDB
MTHFD2
Tchem
Family:  Enzyme
Novelty:  0.01776594
Score:  0.98
Data Source:  STRINGDB
ADSSL1
Tbio
Family:  Enzyme
Novelty:  0.0511949
Score:  0.976
Data Source:  STRINGDB
MTHFD2L
Tdark
Family:  Enzyme
Novelty:  0.18530504
Score:  0.976
Data Source:  STRINGDB
Pathways (19)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of nucleotides
Reactome
Nucleobase biosynthesis
Reactome
Purine ribonucleoside monophosphate biosynthesis
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of nucleotides
Nucleobase biosynthesis
Purine ribonucleoside monophosphate biosynthesis
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (19)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Disease Associations ()
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
7
3
4
1.1
84.6
BMI-adjusted waist-hip ratio
2
2
2
68.8
monocyte count
1
1
1
53.7
myeloid white cell count
1
1
1
47.7
leukocyte count
1
1
1
44.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
1.1
84.6
BMI-adjusted waist-hip ratio
2
68.8
monocyte count
1
53.7
myeloid white cell count
1
47.7
leukocyte count
1
44.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
VGNC:101
459925
Macaque
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
694819
Mouse
MGI:1351352
108147
Rat
RGD:70879
81643
Dog
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
VGNC:38229
488513
Species
Name
OMA
EggNOG
Inparanoid
Chimp
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
Macaque
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
Mouse
Rat
Dog
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
Publication Statistics
PubMed Score 215.85
PubMed score by year
PubTator Score 221.85
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title