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Tbio
ATG9B
Autophagy-related protein 9B

Protein Summary
Description
Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle (By similarity). This gene functions in the regulation of autophagy, a lysosomal degradation pathway. This gene also functions as an antisense transcript in the posttranscriptional regulation of the endothelial nitric oxide synthase 3 gene, which has 3' overlap with this gene on the opposite strand. Mutations in this gene and disruption of the autophagy process have been associated with multiple cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000469530
  • ENSP00000479879
  • ENSG00000181652
  • ENST00000605952
  • ENSP00000475737
  • ENST00000639579
  • ENSP00000491504

Symbol
  • APG9L2
  • NOS3AS
  • SONE
  • APG9L2
  • NOS3AS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
phenotype
0.61
cellular component
0.56
tissue sample
0.51
PubMedID
0.5
tissue
0.48


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 208   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 208   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (4)
FBXL4
Tbio
Novelty:  0.04286856
p_int:  0.999998152
p_ni:  0.000001841
p_wrong:  8e-9
Data Source:  BioPlex
FBXO3
Tbio
Novelty:  0.01701102
p_int:  0.999878642
p_ni:  0.00000453
p_wrong:  0.000116828
Data Source:  BioPlex
KIF3A
Tbio
Novelty:  0.00555124
p_int:  0.999706789
p_ni:  0.000024908
p_wrong:  0.000268303
Data Source:  BioPlex
LACC1
Tbio
Family:  Enzyme
Novelty:  0.03928871
p_int:  0.881123358
p_ni:  0.000263149
p_wrong:  0.118613493
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Autophagy (R-HSA-9612973)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Autophagy
Reactome
Cellular responses to external stimuli
Reactome
Macroautophagy
Name
Explore in Pharos
Explore in Source
Autophagy
Cellular responses to external stimuli
Macroautophagy
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (9)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (36)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
3
3
4
94.2
QT interval
7
9
2
1.6
89.4
electrocardiography
2
2
30
11.9
85.6
Agents acting on the renin-angiotensin system use measurement
1
1
1
81.9
Diuretic use measurement
1
1
1
79
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
4
94.2
QT interval
2
1.6
89.4
electrocardiography
30
11.9
85.6
Agents acting on the renin-angiotensin system use measurement
1
81.9
Diuretic use measurement
1
79
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2685420
213948
Rat
RGD:1560887
499973
Horse
autophagy related 9B
VGNC:15629
100064027
Pig
autophagy related 9B
100462720
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Horse
autophagy related 9B
Pig
autophagy related 9B
Publication Statistics
PubTator Score 6.87
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title