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Tchem
ATG7
Ubiquitin-like modifier-activating enzyme ATG7

Protein Summary
Description
E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress. Plays also a key role in the maintenance of axonal homeostasis, the prevention of axonal degeneration, the maintenance of hematopoietic stem cells, the formation of Paneth cell granules, as well as in adipose differentiation. Plays a role in regulating the liver clock an ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000354449
  • ENSP00000346437
  • ENSG00000197548
  • ENST00000354956
  • ENSP00000347042
  • ENST00000446450
  • ENSP00000412580

Symbol
  • APG7L
  • GSA7
  • APG7L
  • APG7-LIKE
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
interacting protein
1
transcription factor perturbation
0.96
transcription factor binding site profile
0.84
virus perturbation
0.68


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 983.46   (req: < 5)
Gene RIFs: 50   (req: <= 3)
Antibodies: 720   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 983.46   (req: >= 5)
Gene RIFs: 50   (req: > 3)
Antibodies: 720   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 35
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 196
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0