Protein Summary
Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway. May play an important role in the apopto ...more
- ENST00000343245
- ENSP00000343313
- ENSG00000057663
- ENST00000369076
- ENSP00000358072
- ENST00000635758
- ENSP00000490493
- APG5L
- ASP
- ASP
- APG5
- APG5L
- hAPG5
- SCAR25
- APG5-LIKE
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
disease perturbation | 1 | ||
biological process | 0.99 | ||
kinase perturbation | 0.99 | ||
transcription factor perturbation | 0.94 | ||
transcription factor binding site profile | 0.89 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1285.43 (req: < 5)
Gene RIFs: 95 (req: <= 3)
Antibodies: 884 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1285.43 (req: >= 5)
Gene RIFs: 95 (req: > 3)
Antibodies: 884 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 33
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (247)
ATG3
Novelty: 0.00541077
p_int: 0.99999999
p_ni: 7e-9
p_wrong: 2e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
RAB33B
Family: Enzyme
Novelty: 0.06381712
p_int: 0.999999833
p_ni: 1.67e-7
p_wrong: 1e-9
Score: 0.512
Data Source: BioPlex,STRINGDB
CCDC12
Novelty: 0.52297992
p_int: 0.999999802
p_ni: 1.98e-7
Score: 0.534
Data Source: BioPlex,STRINGDB
WIPI2
Novelty: 0.02685992
p_int: 0.999991799
p_ni: 0.000003865
p_wrong: 0.000004336
Score: 0.992
Data Source: BioPlex,Reactome,STRINGDB
IKBIP
Family: Enzyme
Novelty: 0.18707639
p_int: 0.999973371
p_ni: 0.000026623
p_wrong: 7e-9
Score: 0.165
Data Source: BioPlex,STRINGDB
SYCE1
Novelty: 0.05038876
p_int: 0.998756131
p_ni: 0.001220201
p_wrong: 0.000023668
Data Source: BioPlex
CCT2
Novelty: 0.01967139
p_int: 0.988746027
p_ni: 0.011239493
p_wrong: 0.00001448
Data Source: BioPlex
Nearest Tclin Targets
Pathways (25)
Reactome (10)
KEGG (9)
WikiPathways (6)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Autophagy | ||||
Reactome | Cellular responses to external stimuli | ||||
Reactome | DDX58/IFIH1-mediated induction of interferon-alpha/beta | ||||
Reactome | Immune System | ||||
Reactome | Innate Immune System | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Autophagy | ||||
Cellular responses to external stimuli | ||||
DDX58/IFIH1-mediated induction of interferon-alpha/beta | ||||
Immune System | ||||
Innate Immune System | ||||
Viral Interactions (0)
Gene Ontology Terms (42)
Components (9)
Processes (33)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Traceable Author Statement (TAS) | Reactome | |||
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (17)
Items per page:
1 – 5 of 17
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
8 | 5 | 0 | 1.2 | 82.8 | |||||
balding measurement | 1 | 2 | 2 | 81.4 | |||||
eosinophil count | 2 | 2 | 2 | 81 | |||||
3 | 2 | 0 | 1.1 | 76.9 | |||||
childhood onset asthma | 1 | 1 | 0 | 1.1 | 73.2 | ||||
Items per page:
1 – 5 of 17
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
0 | 1.2 | 82.8 | |||||
balding measurement | 2 | 81.4 | |||||
eosinophil count | 2 | 81 | |||||
0 | 1.1 | 76.9 | |||||
childhood onset asthma | 0 | 1.1 | 73.2 | ||||
Find similar targets by:
IDG Resources
Orthologs (17)
1 – 5 of 17
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | autophagy related 5 | VGNC:2644 | 462905 | |||||
Macaque | autophagy related 5 | 696874 | ||||||
Mouse | MGI:1277186 | 11793 | ||||||
Rat | RGD:1359580 | 365601 | ||||||
Dog | autophagy related 5 | VGNC:38226 | 610868 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | autophagy related 5 | |||||
Macaque | autophagy related 5 | |||||
Mouse | ||||||
Rat | ||||||
Dog | autophagy related 5 | |||||
Publication Statistics
PubMed Score 1285.43
PubMed score by year
PubTator Score 513.48
PubTator score by year
Related Publications
Text Mined References (133)
GeneRif Annotations (95)
Items per page:
0 of 0
PMID | Year | Title |
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