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Tbio
ATG4D
Cysteine protease ATG4D

Protein Summary
Description
Cysteine protease ATG4D: Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms. Cysteine protease ATG4D, mitochondrial: Plays a role as an autophagy regulator that links mitochondrial dysfunction with apoptosis. The mitochondrial import of ATG4D during cellular stress and differentiation may play important roles in the regulation of mitochondrial physiology, ROS, mitophagy and cell viability. Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differenti ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000309469
  • ENSP00000311318
  • ENSG00000130734

Symbol
  • APG4D
  • AUTL4
  • APG4D
  • AUTL4
  • APG4-D
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.85
kinase perturbation
0.84
tissue sample
0.67
biological process
0.63
cell line
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.75   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 526   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.75   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 526   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (88)
ATG4C
Tbio
Family:  Enzyme
Novelty:  0.04175533
p_int:  0.99999719
p_ni:  1.68e-7
p_wrong:  0.000002642
Data Source:  BioPlex
GOPC
Tbio
Novelty:  0.01110168
p_int:  0.999995729
p_ni:  7.49e-7
p_wrong:  0.000003522
Score:  0.196
Data Source:  BioPlex,STRINGDB
IMPDH1
Tclin
Family:  Enzyme
Novelty:  0.00758575
p_int:  0.998050466
p_ni:  9.75e-7
p_wrong:  0.001948559
Score:  0.221
Data Source:  BioPlex,STRINGDB
P4HA2
Tbio
Family:  Enzyme
Novelty:  0.02097718
p_int:  0.993482902
p_ni:  0.000001406
p_wrong:  0.006515692
Score:  0.253
Data Source:  BioPlex,STRINGDB
CCT2
Tbio
Novelty:  0.01967139
p_int:  0.882630471
p_ni:  0.000055601
p_wrong:  0.117313928
Data Source:  BioPlex
GABARAPL1
Tbio
Novelty:  0.00212657
Score:  0.986
Data Source:  STRINGDB
GABARAPL2
Tbio
Novelty:  0.0022546
Score:  0.983
Data Source:  STRINGDB
GABARAP
Tbio
Novelty:  0.00444901
Score:  0.976
Data Source:  STRINGDB
MAP1LC3A
Tbio
Novelty:  0.00301583
Score:  0.972
Data Source:  STRINGDB
MAP1LC3B
Tbio
Novelty:  0.00101276
Score:  0.967
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Autophagy (R-HSA-9612973)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Autophagy
Reactome
Cellular responses to external stimuli
Reactome
Macroautophagy
Name
Explore in Pharos
Explore in Source
Autophagy
Cellular responses to external stimuli
Macroautophagy
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (26)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
3
8
9
98.4
total cholesterol measurement
2
7
8
97.7
apolipoprotein B measurement
1
5
5
97.6
red blood cell distribution width
4
5
6
96.4
reticulocyte measurement
3
2
3
94.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
9
98.4
total cholesterol measurement
8
97.7
apolipoprotein B measurement
5
97.6
red blood cell distribution width
6
96.4
reticulocyte measurement
3
94.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
autophagy related 4D cysteine peptidase
VGNC:10157
455708
Mouse
MGI:2444308
235040
Rat
RGD:1596392
686505
Dog
autophagy related 4D cysteine peptidase
VGNC:38225
484953
Horse
autophagy related 4D cysteine peptidase
VGNC:15625
100057841
Species
Name
OMA
EggNOG
Inparanoid
Chimp
autophagy related 4D cysteine peptidase
Mouse
Rat
Dog
autophagy related 4D cysteine peptidase
Horse
autophagy related 4D cysteine peptidase
Publication Statistics
PubMed Score 15.75
PubMed score by year
PubTator Score 6.04
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title