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Tchem
ATG4B
Cysteine protease ATG4B

Protein Summary
Description
Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3, GABARAPL1, GABARAPL2 and GABARAP, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms. Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000402096
  • ENSP00000384661
  • ENSG00000168397
  • ENST00000404914
  • ENSP00000384259
  • ENST00000405546
  • ENSP00000383964

Symbol
  • APG4B
  • AUTL1
  • KIAA0943
  • APG4B
  • AUTL1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
virus perturbation
0.95
interacting protein
0.93
histone modification site profile
0.76
biological process
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 122.43   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 596   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 122.43   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 596   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 25
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (25)
SID24807290
Rendered image for SID24807290
SID17408613
Rendered image for SID17408613
SID17387729
Rendered image for SID17387729
SID22409176
Rendered image for SID22409176
SID17507435
Rendered image for SID17507435
SID17413719
Rendered image for SID17413719
CHEMBL4520267
Rendered image for CHEMBL4520267
CHEMBL4581663
Rendered image for CHEMBL4581663
CHEMBL4546760
Rendered image for CHEMBL4546760
Protein-Protein Interactions (102)
FANK1
Tbio
Novelty:  0.12389783
p_int:  0.999999099
p_ni:  3.56e-7
p_wrong:  5.45e-7
Score:  0.555
Data Source:  BioPlex,STRINGDB
STK16
Tchem
Family:  Kinase
Novelty:  0.01499094
p_int:  0.999993406
p_ni:  0.00000353
p_wrong:  0.000003065
Score:  0.269
Data Source:  BioPlex,STRINGDB
CARTPT
Tbio
Novelty:  0.00224864
p_int:  0.920494128
p_ni:  0.030229643
p_wrong:  0.049276229
Data Source:  BioPlex
GABARAPL1
Tbio
Novelty:  0.00212657
Score:  0.997
Data Source:  STRINGDB
GABARAP
Tbio
Novelty:  0.00444901
Score:  0.997
Data Source:  STRINGDB
GABARAPL2
Tbio
Novelty:  0.0022546
Score:  0.995
Data Source:  STRINGDB
MAP1LC3A
Tbio
Novelty:  0.00301583
Score:  0.995
Data Source:  STRINGDB
MAP1LC3B
Tbio
Novelty:  0.00101276
Score:  0.992
Data Source:  STRINGDB
MAP1LC3C
Tbio
Novelty:  0.04062334
Score:  0.989
Data Source:  STRINGDB
ATG3
Tbio
Novelty:  0.00541077
Score:  0.949
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Autophagy (R-HSA-9612973)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Autophagy
Reactome
Cellular responses to external stimuli
Reactome
Macroautophagy
Name
Explore in Pharos
Explore in Source
Autophagy
Cellular responses to external stimuli
Macroautophagy
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (28)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
6
2
2
1.1
90.7
eosinophil count
3
1
3
86.9
10
1
0
1.1
86.2
eosinophil percentage of leukocytes
2
1
2
86.1
childhood onset asthma
2
1
0
1.2
86.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1.1
90.7
eosinophil count
3
86.9
0
1.1
86.2
eosinophil percentage of leukocytes
2
86.1
childhood onset asthma
0
1.2
86.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
autophagy related 4B cysteine peptidase
VGNC:99
748674
Macaque
autophagy related 4B cysteine peptidase
717813
Mouse
MGI:1913865
66615
Rat
RGD:1309664
316640
Dog
autophagy related 4B cysteine peptidase
VGNC:49762
609599
Species
Name
OMA
EggNOG
Inparanoid
Chimp
autophagy related 4B cysteine peptidase
Macaque
autophagy related 4B cysteine peptidase
Mouse
Rat
Dog
autophagy related 4B cysteine peptidase
Publication Statistics
PubMed Score 122.43
PubMed score by year
PubTator Score 51.57
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title