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Tbio
ATG3
Ubiquitin-like-conjugating enzyme ATG3

Protein Summary
Description
E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt), autophagy, and mitochondrial homeostasis. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A). The ATG12-ATG5 conjugate plays a role of an E3 and promotes the transfer of ATG8-like proteins from ATG3 to phosphatidylethanolamine (PE). This step is required for the membrane association of ATG8-like proteins. The formation of the ATG8-phosphatidylethanolamine conjugates is essential for autophagy and for the cytoplasm to vacuole transport (Cvt). Preferred substrate is MAP1LC3A. Also acts as an autocatalytic E2-like enzyme, catalyzing the conjugation of ATG12 to itself, ATG12 conjugation to ATG3 playing a role in mitochondrial homeostasis but not in autophagy. ATG7 (E1-like enzyme) facilitates this reaction by forming an E1-E2 complex with ATG3. Promotes primary ciliogenesis by removing OFD1 from centriolar ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000283290
  • ENSP00000283290
  • ENSG00000144848
  • ENST00000402314
  • ENSP00000385943

Symbol
  • APG3
  • APG3L
  • APG3
  • APG3L
  • PC3-96
  • APG3-LIKE
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.99
histone modification site profile
0.88
transcription factor perturbation
0.8
hub protein
0.75
tissue sample
0.68


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 206.72   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 638   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 206.72   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 638   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (134)
ATG7
Tchem
Novelty:  0.00120728
p_int:  0.999999999
p_ni:  1e-9
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
ATG5
Tbio
Novelty:  0.00081472
p_int:  0.99999999
p_ni:  7e-9
p_wrong:  2e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
ATG16L1
Tbio
Novelty:  0.0031765
p_int:  0.999999981
p_ni:  1.7e-8
p_wrong:  1e-9
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
ATG12
Tbio
Novelty:  0.00304298
p_int:  0.999982687
p_ni:  1.5e-8
p_wrong:  0.000017297
Score:  0.999
Data Source:  BioPlex,STRINGDB
GABARAP
Tbio
Novelty:  0.00444901
p_int:  0.999954646
p_ni:  0.000042955
p_wrong:  0.000002398
Score:  0.995
Data Source:  BioPlex,STRINGDB
MAP1LC3B2
Tdark
Novelty:  0.30477576
p_int:  0.999884272
p_ni:  0.000115728
Score:  0.858
Data Source:  BioPlex,STRINGDB
FGB
Tbio
Novelty:  0.00437751
p_int:  0.99428714
p_ni:  0.002169498
p_wrong:  0.003543362
Data Source:  BioPlex
SPANXN4
Tdark
Novelty:  1.91062423
p_int:  0.990593246
p_ni:  0.000558181
p_wrong:  0.008848573
Data Source:  BioPlex
C2orf73
Tdark
Novelty:  0.8689571
p_int:  0.990233015
p_ni:  0.005668426
p_wrong:  0.00409856
Data Source:  BioPlex
GNAQ
Tbio
Novelty:  0.0008997
p_int:  0.984858431
p_ni:  0.015141543
p_wrong:  2.6e-8
Score:  0.151
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (9)
Autophagy (R-HSA-9612973)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Autophagy
Reactome
Cellular responses to external stimuli
Reactome
Macroautophagy
Name
Explore in Pharos
Explore in Source
Autophagy
Cellular responses to external stimuli
Macroautophagy
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
68.3
corneal resistance factor
1
1
1
51.8
1
1
0
1.3
45.5
central corneal thickness
1
1
0
1.5
34.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
68.3
corneal resistance factor
1
51.8
0
1.3
45.5
central corneal thickness
0
1.5
34.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
autophagy related 3
VGNC:1740
470880
Macaque
autophagy related 3
708305
Mouse
MGI:1915091
67841
Rat
RGD:708464
171415
Dog
autophagy related 3
478564
Species
Name
OMA
EggNOG
Inparanoid
Chimp
autophagy related 3
Macaque
autophagy related 3
Mouse
Rat
Dog
autophagy related 3
Publication Statistics
PubMed Score 206.72
PubMed score by year
PubTator Score 55.38
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title