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Tbio
ATG2B
Autophagy-related protein 2 homolog B

Protein Summary
Description
Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion. This gene encodes a protein required for autophagy. The encoded protein is involved in autophagosome formation. A germline duplication of a region that includes this gene is associated with predisposition to myeloid malignancies. [provided by RefSeq, Jul 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359933
  • ENSP00000353010
  • ENSG00000066739

Symbol
  • C14orf103
  • C14orf103
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.9
drug perturbation
0.71
microRNA
0.67
tissue sample
0.66
disease perturbation
0.62


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.63   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 130   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.63   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (79)
LHX6
Tbio
Family:  TF
Novelty:  0.01603143
p_int:  0.999999905
p_ni:  9.5e-8
Score:  0.538
Data Source:  BioPlex,STRINGDB
HDAC11
Tclin
Family:  Epigenetic
Novelty:  0.01015211
p_int:  0.999995964
p_ni:  0.000004036
Score:  0.189
Data Source:  BioPlex,STRINGDB
WDR45
Tbio
Novelty:  0.0148072
p_int:  0.999980009
p_ni:  0.000019991
Score:  0.947
Data Source:  BioPlex,STRINGDB
SALL2
Tbio
Family:  TF
Novelty:  0.01181421
p_int:  0.999615714
p_ni:  0.000384286
Score:  0.377
Data Source:  BioPlex,STRINGDB
NPAS1
Tbio
Family:  TF
Novelty:  0.08014425
p_int:  0.998224373
p_ni:  0.001775625
p_wrong:  2e-9
Data Source:  BioPlex
ARSK
Tbio
Family:  Enzyme
Novelty:  0.11486213
p_int:  0.996886902
p_ni:  0.003112742
p_wrong:  3.57e-7
Data Source:  BioPlex
ARHGAP36
Tbio
Family:  Enzyme
Novelty:  0.33342126
p_int:  0.993721343
p_ni:  0.006278656
p_wrong:  1e-9
Data Source:  BioPlex
SKP2
Tbio
Family:  Enzyme
Novelty:  0.00182658
p_int:  0.992925319
p_ni:  0.007074675
p_wrong:  6e-9
Data Source:  BioPlex
TACR3
Tchem
Family:  GPCR
Novelty:  0.00351352
p_int:  0.989267399
p_ni:  0.010732599
p_wrong:  2e-9
Data Source:  BioPlex
TKT
Tchem
Family:  Enzyme
Novelty:  0.00333936
p_int:  0.987144627
p_ni:  0.012855373
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (7)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
autophagy related 2B
VGNC:3477
453143
Mouse
MGI:1923809
76559
Rat
RGD:1304878
314415
Dog
autophagy related 2B
VGNC:38222
480428
Horse
autophagy related 2B
VGNC:15621
100054652
Species
Name
OMA
EggNOG
Inparanoid
Chimp
autophagy related 2B
Mouse
Rat
Dog
autophagy related 2B
Horse
autophagy related 2B
Publication Statistics
PubMed Score 22.63
PubMed score by year
PubTator Score 8.03
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title