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Tbio
ATG12
Ubiquitin-like protein ATG12

Protein Summary
Description
Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. (Microbial infection) May act as a proviral factor. In association with ATG5, negatively regulates the innate antiviral immune response by impairing the type I IFN production pathway upon vesicular stomatitis virus (VSV) infection (PubMed:17709747). Required for the translation of incoming hepatitis C virus (HCV) RNA and, thereby, for the initiation of HCV replication, but not required once infection is established (PubMed:19666601). Autophagy is a process of bulk protein degradation in which cytoplasmic components, including organelles, are enclosed in double-membrane structures ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000500945
  • ENSP00000425164
  • ENSG00000145782
  • ENST00000509910
  • ENSP00000425107

Symbol
  • APG12
  • APG12L
  • APG12
  • FBR93
  • APG12L
  • HAPG12
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.94
histone modification site profile
0.85
kinase perturbation
0.81
hub protein
0.79
transcription factor binding site profile
0.76


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 281.1   (req: < 5)
Gene RIFs: 28   (req: <= 3)
Antibodies: 709   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 281.1   (req: >= 5)
Gene RIFs: 28   (req: > 3)
Antibodies: 709   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (152)
RAB33B
Tbio
Family:  Enzyme
Novelty:  0.06381712
p_int:  0.999999235
p_ni:  7.65e-7
p_wrong:  1e-9
Score:  0.507
Data Source:  BioPlex,STRINGDB
ATG3
Tbio
Novelty:  0.00541077
p_int:  0.999982687
p_ni:  1.5e-8
p_wrong:  0.000017297
Score:  0.999
Data Source:  BioPlex,STRINGDB
ATG10
Tbio
Novelty:  0.0167153
p_int:  0.999935135
p_ni:  7.5e-8
p_wrong:  0.00006479
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
ATG7
Tchem
Novelty:  0.00120728
Score:  0.999
Data Source:  Reactome,STRINGDB
ATG5
Tbio
Novelty:  0.00081472
Score:  0.999
Data Source:  Reactome,STRINGDB
BECN1
Tbio
Novelty:  0.0003792
Score:  0.997
Data Source:  STRINGDB
ATG16L1
Tbio
Novelty:  0.0031765
Score:  0.996
Data Source:  Reactome,STRINGDB
GABARAPL1
Tbio
Novelty:  0.00212657
Score:  0.995
Data Source:  STRINGDB
GABARAPL2
Tbio
Novelty:  0.0022546
Score:  0.994
Data Source:  STRINGDB
PIK3C3
Tchem
Family:  Kinase
Novelty:  0.00269825
Score:  0.993
Data Source:  STRINGDB
Nearest Tclin Targets (3)
Explore Nearest Tclin Targets
1 – 3 of 3
MAP2K1
Tclin
Family:  Kinase
KEGG Distance:  3
Common Pathways:  2
MAP2K2
Tclin
Family:  Kinase
KEGG Distance:  3
Common Pathways:  2
IL6
Tclin
Family:  Other
KEGG Distance:  3
Common Pathways:  2
Pathways (20)
Autophagy (R-HSA-9612973)

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Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Autophagy
Reactome
Cellular responses to external stimuli
Reactome
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Autophagy
Cellular responses to external stimuli
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Immune System
Innate Immune System
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (10)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
central corneal thickness
2
1
0
2.4
24.2
alkaline phosphatase measurement
2
1
1
6.6
17
intraocular pressure measurement
1
1
1
10.1
mean corpuscular hemoglobin concentration
1
1
1
7.1
BMI-adjusted waist circumference
1
1
1
2.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
central corneal thickness
0
2.4
24.2
alkaline phosphatase measurement
1
6.6
17
intraocular pressure measurement
1
10.1
mean corpuscular hemoglobin concentration
1
7.1
BMI-adjusted waist circumference
1
2.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
autophagy related 12
VGNC:11833
462011
Mouse
MGI:1914776
67526
Rat
RGD:1306306
361321
Dog
autophagy related 12
VGNC:38216
474636
Horse
autophagy related 12
VGNC:15617
100073160
Species
Name
OMA
EggNOG
Inparanoid
Chimp
autophagy related 12
Mouse
Rat
Dog
autophagy related 12
Horse
autophagy related 12
Publication Statistics
PubMed Score 281.10
PubMed score by year
PubTator Score 97.72
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title