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Tbio
ATG10
Ubiquitin-like-conjugating enzyme ATG10

Protein Summary
Description
E2-like enzyme involved in autophagy. Acts as an E2-like enzyme that catalyzes the conjugation of ATG12 to ATG5. ATG12 conjugation to ATG5 is required for autophagy. Likely serves as an ATG5-recognition molecule. Not involved in ATG12 conjugation to ATG3 (By similarity). Plays a role in adenovirus-mediated cell lysis. Autophagy is a process for the bulk degradation of cytosolic compartments by lysosomes. ATG10 is an E2-like enzyme involved in 2 ubiquitin-like modifications essential for autophagosome formation: ATG12 (MIM 609608)-ATG5 (MIM 604261) conjugation and modification of a soluble form of MAP-LC3 (MAP1LC3A; MIM 601242), a homolog of yeast Apg8, to a membrane-bound form (Nemoto et al., 2003 [PubMed 12890687]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000282185
  • ENSP00000282185
  • ENSG00000152348
  • ENST00000355178
  • ENSP00000347309
  • ENST00000458350
  • ENSP00000404938
  • ENST00000513443
  • ENSP00000425182

Symbol
  • APG10L
  • APG10
  • APG10L
  • pp12616
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.92
virus perturbation
0.76
small molecule perturbation
0.7
transcription factor binding site profile
0.7
transcription factor perturbation
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.1   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 334   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.1   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 334   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (68)
ATG12
Tbio
Novelty:  0.00304298
p_int:  0.999935135
p_ni:  7.5e-8
p_wrong:  0.00006479
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
ATG7
Tchem
Novelty:  0.00120728
p_int:  0.999928267
p_ni:  0.000071733
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
ATG5
Tbio
Novelty:  0.00081472
Score:  0.996
Data Source:  Reactome,STRINGDB
ATG16L1
Tbio
Novelty:  0.0031765
Score:  0.988
Data Source:  STRINGDB
ATG3
Tbio
Novelty:  0.00541077
Score:  0.961
Data Source:  STRINGDB
BECN1
Tbio
Novelty:  0.0003792
Score:  0.894
Data Source:  STRINGDB
PIK3C3
Tchem
Family:  Kinase
Novelty:  0.00269825
Score:  0.889
Data Source:  STRINGDB
ATG101
Tbio
Novelty:  0.03407206
Score:  0.874
Data Source:  STRINGDB
PIK3R4
Tbio
Family:  Kinase
Novelty:  0.01412698
Score:  0.873
Data Source:  STRINGDB
ATG13
Tbio
Novelty:  0.00951471
Score:  0.87
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Autophagy (R-HSA-9612973)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Autophagy
Reactome
Cellular responses to external stimuli
Reactome
Macroautophagy
Name
Explore in Pharos
Explore in Source
Autophagy
Cellular responses to external stimuli
Macroautophagy
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
2
3
69.1
3
2
0
1.1
59.4
cognitive function measurement
3
1
3
53.7
risk-taking behaviour
2
2
2
52.7
self reported educational attainment
1
1
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
69.1
0
1.1
59.4
cognitive function measurement
3
53.7
risk-taking behaviour
2
52.7
self reported educational attainment
1
21.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
autophagy related 10
VGNC:3907
461768
Macaque
autophagy related 10
711835
Mouse
MGI:1914045
66795
Rat
RGD:1587624
688555
Dog
autophagy related 10
VGNC:38214
610103
Species
Name
OMA
EggNOG
Inparanoid
Chimp
autophagy related 10
Macaque
autophagy related 10
Mouse
Rat
Dog
autophagy related 10
Publication Statistics
PubMed Score 51.10
PubMed score by year
PubTator Score 20.61
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title