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Tbio
ATF7
Cyclic AMP-dependent transcription factor ATF-7

Protein Summary
Description
Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters. Activator of the NF-ELAM1/delta-A site of the E-selectin promoter. Has no intrinsic transcriptional activity, but activates transcription on formation of JUN or FOS heterodimers. Also can bind TRE promoter sequences when heterodimerized with members of the JUN family. Isoform 4 acts as a dominant repressor of the E-selectin/NF-ELAM1/delta-A promoter. Isoform 5 acts as a negative regulator, inhibiting both ATF2 and ATF7 transcriptional activities. It may exert these effects by sequestrating in the cytoplasm the Thr-53 phosphorylating kinase, preventing activation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000420353
  • ENSP00000399465
  • ENSG00000170653
  • ENST00000456903
  • ENSP00000387406
  • ENST00000548118
  • ENSP00000456858
  • ENST00000548446
  • ENSP00000449938
  • ENST00000591397
  • ENSP00000465192

Symbol
  • ATFA
  • ATFA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.83
transcription factor binding site profile
0.8
transcription factor perturbation
0.8
protein domain
0.73
transcription factor
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 129.05   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 263   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 129.05   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 263   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0