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Tbio
ATF2
Cyclic AMP-dependent transcription factor ATF-2

Protein Summary
Description
Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'). In the nucleus, contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, proliferation and death. In the cytoplasm, interacts with and perturbs HK1- and VDAC1-containing complexes at the mitochondrial outer membrane, thereby impairing mitochondrial membrane potential, inducing mitochondrial leakage and promoting cell death. The phosphorylated form (mediated by ATM) plays a role in the DNA damage response and is involved in the ionizing radiation (IR)-induced S phase checkpoint control and in the recruitment of the MRN complex into the IR-induced foci (IRIF). ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264110
  • ENSP00000264110
  • ENSG00000115966
  • ENST00000345739
  • ENSP00000340576
  • ENST00000392544
  • ENSP00000376327
  • ENST00000409499
  • ENSP00000386282
  • ENST00000409635
  • ENSP00000387093
  • ENST00000409833
  • ENSP00000386526
  • ENST00000426833
  • ENSP00000407911

Symbol
  • CREB2
  • CREBP1
  • HB16
  • CREB2
  • TREB7
  • CREB-2
  • CRE-BP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
kinase
1
molecular function
1
co-expressed gene
0.99
biological process
0.98


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 249.72   (req: < 5)
Gene RIFs: 103   (req: <= 3)
Antibodies: 2316   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 249.72   (req: >= 5)
Gene RIFs: 103   (req: > 3)
Antibodies: 2316   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 38
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0