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Tbio
ATAD5
ATPase family AAA domain-containing protein 5

Protein Summary
Description
Involved in DNA damage response. Involved in a RAD9A-related damage checkpoint, a pathway that is important in determining whether DNA damage is compatible with cell survival or whether it requires cell elimination by apoptosis. Modulates the RAD9A interaction with BCL2 and thereby induces DNA damages-induced apoptosis.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000321990
  • ENSP00000313171
  • ENSG00000176208

Symbol
  • C17orf41
  • FRAG1
  • ELG1
  • FRAG1
  • C17orf41
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
0.87
histone modification site profile
0.81
cell line
0.76
transcription factor perturbation
0.74
molecular function
0.73


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.16   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 145   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.16   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 145   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (140)
BRD4
Tchem
Family:  Epigenetic
Novelty:  0.0013933
p_int:  0.999999989
p_ni:  9e-9
p_wrong:  2e-9
Score:  0.432
Data Source:  BioPlex,STRINGDB
RFC4
Tbio
Novelty:  0.03232586
p_int:  0.999999981
p_ni:  5e-9
p_wrong:  1.4e-8
Score:  0.991
Data Source:  BioPlex,STRINGDB
RFC5
Tbio
Novelty:  0.03987481
p_int:  0.999999806
p_ni:  1.94e-7
p_wrong:  1e-9
Score:  0.994
Data Source:  BioPlex,STRINGDB
RFC2
Tbio
Novelty:  0.02088405
Score:  0.964
Data Source:  STRINGDB
RAD9A
Tbio
Novelty:  0.00560195
Score:  0.962
Data Source:  STRINGDB
RFC3
Tbio
Novelty:  0.02712951
Score:  0.943
Data Source:  STRINGDB
WDHD1
Tbio
Novelty:  0.01511313
Score:  0.916
Data Source:  STRINGDB
RAD17
Tbio
Novelty:  0.00640979
Score:  0.915
Data Source:  STRINGDB
SMC2
Tchem
Novelty:  0.06898543
Score:  0.88
Data Source:  STRINGDB
PCNA
Tchem
Novelty:  0.03909539
Score:  0.877
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (18)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
3
10
12
94.4
BMI-adjusted waist circumference
4
9
12
93.1
body height
3
2
2
6
92
mean corpuscular volume
2
2
2
89.9
body weights and measures
1
1
1
86.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
12
94.4
BMI-adjusted waist circumference
12
93.1
body height
2
6
92
mean corpuscular volume
2
89.9
body weights and measures
1
86.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ATPase family, AAA domain containing 5
VGNC:9125
454559
Mouse
MGI:2442925
237877
Rat
RGD:1561464
303348
Dog
ATPase family, AAA domain containing 5
VGNC:38203
491156
Horse
ATPase family, AAA domain containing 5
VGNC:15605
100058527
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ATPase family, AAA domain containing 5
Mouse
Rat
Dog
ATPase family, AAA domain containing 5
Horse
ATPase family, AAA domain containing 5
Publication Statistics
PubMed Score 53.16
PubMed score by year
PubTator Score 19.73
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title