Tchem ATAD2 ATPase family AAA domain-containing protein 2

Protein Summary

Description

May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells. A large family of ATPases has been described, whose key feature is that they share a conserved region of about 220 amino acids that contains an ATP-binding site. The proteins that belong to this family either contain one or two AAA (ATPases Associated with diverse cellular Activities) domains. AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes. The protein encoded by this gene contains two AAA domains, as well as a bromodomain. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q6PL18
• Q14CR1
• Q658P2
• Q68CQ0
• Q6PJV6
• Q8N890
• Q9UHS5

Gene Name

• ATAD2

Ensembl ID

• ENST00000287394
• ENSP00000287394
• ENSG00000156802

Symbol

• ANCCA
• CT137
• PRO2000

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.97
molecular function	0.95
protein domain	0.85
transcription factor perturbation	0.84
ligand (protein) perturbation	0.83

Protein Classes

PANTHER Classes

Protein / Hydrolase / Atpase Family Aaa Domain-containing Protein 2

DTO Classes

Protein / Epigenetic Regulator / Reader / Bromodomain / Atpase Family Aaa Domain-containing Protein 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 165.08   (req: < 5)

Gene RIFs: 56   (req: <= 3)

Antibodies: 147   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 165.08   (req: >= 5)

Gene RIFs: 56   (req: > 3)

Antibodies: 147   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 46

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0