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Tbio
ATAD1
ATPase family AAA domain-containing protein 1

Protein Summary
Description
ATPase that plays a critical role in regulating the surface expression of AMPA receptors (AMPAR), thereby regulating synaptic plasticity and learning and memory. Required for NMDA-stimulated AMPAR internalization and inhibition of GRIA1 and GRIA2 recycling back to the plasma membrane; these activities are ATPase-dependent (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000308448
  • ENSP00000339017
  • ENSG00000138138
  • ENST00000328142
  • ENSP00000339016
  • ENST00000634773
  • ENSP00000489353
  • ENSG00000283024
  • ENST00000634970
  • ENSP00000489455

Symbol
  • AFDC1
  • HKPX4
  • FNP001
  • THORASE
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.93
histone modification site profile
0.88
virus perturbation
0.79
transcription factor binding site profile
0.75
kinase perturbation
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.36   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 151   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.36   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 151   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (66)
TPM2
Tbio
Novelty:  0.00406572
p_int:  0.949174167
p_ni:  0.050823422
p_wrong:  0.00000241
Score:  0.238
Data Source:  BioPlex,STRINGDB
MAS1
Tchem
Family:  GPCR
Novelty:  0.0089712
p_int:  0.776062026
p_ni:  0.223937974
Score:  0.207
Data Source:  BioPlex,STRINGDB
FAF2
Tbio
Novelty:  0.03048598
p_int:  0.75456766
p_ni:  0.245432339
p_wrong:  1e-9
Score:  0.477
Data Source:  BioPlex,STRINGDB
UBXN7
Tbio
Novelty:  0.07437638
Score:  0.758
Data Source:  STRINGDB
COMMD5
Tbio
Novelty:  0.16163787
Score:  0.749
Data Source:  STRINGDB
KYAT3
Tbio
Family:  Enzyme
Novelty:  0.05845124
Score:  0.73
Data Source:  STRINGDB
MARC2
Tbio
Novelty:  0.05210077
Score:  0.699
Data Source:  STRINGDB
CHTF18
Tbio
Novelty:  0.02470494
Score:  0.69
Data Source:  STRINGDB
GOSR1
Tbio
Novelty:  0.03139481
Score:  0.665
Data Source:  STRINGDB
EIF4E
Tchem
Novelty:  0.00072182
Score:  0.643
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (2)
Class I peroxisomal membrane protein import (R-HSA-9603798)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class I peroxisomal membrane protein import
Reactome
Protein localization
Name
Explore in Pharos
Explore in Source
Class I peroxisomal membrane protein import
Protein localization
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (46)
Items per page:
1 – 5 of 46
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
4
4
96.7
eosinophil count
3
4
4
96.7
eosinophil percentage of leukocytes
2
2
2
89.5
eosinophil percentage of leukocytes
2
2
2
89.5
neutrophil count
2
2
2
88.2
Items per page:
1 – 5 of 46
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
4
96.7
eosinophil count
4
96.7
eosinophil percentage of leukocytes
2
89.5
eosinophil percentage of leukocytes
2
89.5
neutrophil count
2
88.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ATPase family, AAA domain containing 1
VGNC:7840
450580
Macaque
ATPase family, AAA domain containing 1
704809
Mouse
MGI:1915229
67979
Rat
RGD:1308570
309532
Dog
ATPase family, AAA domain containing 1
VGNC:38200
477584
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ATPase family, AAA domain containing 1
Macaque
ATPase family, AAA domain containing 1
Mouse
Rat
Dog
ATPase family, AAA domain containing 1
Publication Statistics
PubMed Score 22.36
PubMed score by year
PubTator Score 6.52
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title