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Tbio
ASXL1
Putative Polycomb group protein ASXL1

Protein Summary
Description
Probable Polycomb group (PcG) protein involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as retinoic acid receptors (RARs) and peroxisome proliferator-activated receptor gamma (PPARG). Acts as coactivator of RARA and RXRA through association with NCOA1. Acts as corepressor for PPARG and suppresses its adipocyte differentiation-inducing activity (By similarity). Non-catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1). This gene is similar to the Drosophila additional sex combs gene, which encodes a chromatin-binding protein required for normal determination of segment identity in the developing embryo. The protein is a member of the Polycomb group of proteins, which are necessary for the maintenance of stable repression of homeotic and other loci. The protein is thought to disrupt chromatin in localized areas, enhancing transcription of cer ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375687
  • ENSP00000364839
  • ENSG00000171456
  • ENST00000613218
  • ENSP00000480487
  • ENST00000620121
  • ENSP00000481978

Symbol
  • KIAA0978
  • MDS
  • BOPS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.98
transcription factor perturbation
0.97
disease perturbation
0.96
transcription factor binding site profile
0.95
biological process
0.89


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 439.14   (req: < 5)
Gene RIFs: 105   (req: <= 3)
Antibodies: 98   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 439.14   (req: >= 5)
Gene RIFs: 105   (req: > 3)
Antibodies: 98   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (137)
BAP1
Tbio
Family:  Enzyme
Novelty:  0.00501435
p_int:  0.999999998
p_ni:  2e-9
p_wrong:  1e-9
Score:  0.978
Data Source:  BioPlex,Reactome,STRINGDB
EZH2
Tclin
Family:  Epigenetic
Novelty:  0.00052816
Score:  0.991
Data Source:  STRINGDB
SUZ12
Tbio
Novelty:  0.00402353
Score:  0.965
Data Source:  STRINGDB
FOXK2
Tbio
Family:  TF
Novelty:  0.01420141
Score:  0.962
Data Source:  Reactome,STRINGDB
HCFC1
Tbio
Novelty:  0.00440762
Score:  0.962
Data Source:  Reactome,STRINGDB
FOXK1
Tbio
Family:  TF
Novelty:  0.01321144
Score:  0.957
Data Source:  Reactome,STRINGDB
OGT
Tchem
Family:  Enzyme
Novelty:  0.00290822
Score:  0.952
Data Source:  Reactome,STRINGDB
EZH1
Tchem
Family:  Epigenetic
Novelty:  0.02636757
Score:  0.951
Data Source:  STRINGDB
UBC
Tbio
Novelty:  0.00204643
Score:  0.948
Data Source:  STRINGDB
EED
Tchem
Novelty:  0.00615758
Score:  0.946
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Deubiquitination (R-HSA-5688426)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deubiquitination
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
UCH proteinases
Name
Explore in Pharos
Explore in Source
Deubiquitination
Metabolism of proteins
Post-translational protein modification
UCH proteinases
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (24)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (33)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
3
4
4
95
suntan
1
2
2
86.1
monocyte percentage of leukocytes
2
3
3
78.7
reticulocyte measurement
3
2
3
78.6
smoking behaviour measurement
1
1
1
78.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
95
suntan
2
86.1
monocyte percentage of leukocytes
3
78.7
reticulocyte measurement
3
78.6
smoking behaviour measurement
1
78.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
additional sex combs like 1, transcriptional regulator
VGNC:6045
458168
Macaque
additional sex combs like 1, transcriptional regulator
711799
Mouse
MGI:2684063
228790
Rat
RGD:1561878
311553
Dog
ASXL transcriptional regulator 1
VGNC:38196
100688017
Species
Name
OMA
EggNOG
Inparanoid
Chimp
additional sex combs like 1, transcriptional regulator
Macaque
additional sex combs like 1, transcriptional regulator
Mouse
Rat
Dog
ASXL transcriptional regulator 1
Publication Statistics
PubMed Score 439.14
PubMed score by year
PubTator Score 196.29
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title