Tbio ASPSCR1 Tether containing UBX domain for GLUT4

Protein Summary

Description

Tethering protein that sequesters GLUT4-containing vesicles in the cytoplasm in the absence of insulin. Modulates the amount of GLUT4 that is available at the cell surface (By similarity). Enhances VCP methylation catalyzed by VCPKMT. The protein encoded by this gene contains a UBX domain and interacts with glucose transporter type 4 (GLUT4). This protein is a tether, which sequesters the GLUT4 in intracellular vesicles in muscle and fat cells in the absence of insulin, and redistributes the GLUT4 to the plasma membrane within minutes of insulin stimulation. Translocation t(X;17)(p11;q25) of this gene with transcription factor TFE3 gene results in a ASPSCR1-TFE3 fusion protein in alveolar soft part sarcoma and in renal cell carcinomas. Multiple alternatively spliced transcript variants have been found. [provided by RefSeq, Oct 2011]

Uniprot Accession IDs

• Q9BZE9
• A8K3K9
• Q7Z6N7
• Q8WV59
• Q96LS5
• Q96M40

Gene Name

• ASPSCR1

Ensembl ID

• ENST00000306729
• ENSP00000306625
• ENSG00000169696
• ENST00000306739
• ENSP00000302176
• ENST00000580534
• ENSP00000462329

Symbol

• ASPL
• RCC17
• TUG
• UBXD9
• UBXN9
• TUG
• ASPL
• ASPS
• RCC17
• UBXD9
• UBXN9
• ASPCR1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.81
histone modification site profile	0.77
cellular component	0.73
small molecule perturbation	0.73
interacting protein	0.72

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 124.04   (req: < 5)

Gene RIFs: 19   (req: <= 3)

Antibodies: 282   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 124.04   (req: >= 5)

Gene RIFs: 19   (req: > 3)

Antibodies: 282   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0