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Tbio
ASPRV1
Retroviral-like aspartic protease 1

Protein Summary
Description
Filaggrin is a structural protein that is crucial for in the development and maintenance of the skin barrier. This gene encodes a retroviral-like protease involved in profilaggrin-to-filaggrin processing. Expression is found primarily in the epidermis and inner root sheath of hair follicles. [provided by RefSeq, May 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000320256
  • ENSP00000315383
  • ENSG00000244617

Symbol
  • SASP
  • MUNO
  • SASP
  • Taps
  • SASPase
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.76
cell line
0.56
tissue sample
0.48
protein complex
0.41
protein domain
0.41


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.05   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 72   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.05   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 72   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (30)
WDR45B
Tbio
Novelty:  0.22407227
p_int:  0.999413362
p_ni:  0.000586637
Score:  0.158
Data Source:  BioPlex,STRINGDB
GNB1L
Tbio
Novelty:  0.03388865
p_int:  0.97917298
p_ni:  0.02082646
p_wrong:  5.6e-7
Score:  0.188
Data Source:  BioPlex,STRINGDB
FCF1
Tdark
Novelty:  0.04202976
p_int:  0.953692289
p_ni:  0.046307708
p_wrong:  2e-9
Data Source:  BioPlex
MAS1
Tchem
Family:  GPCR
Novelty:  0.0089712
p_int:  0.838348618
p_ni:  0.159841564
p_wrong:  0.001809817
Data Source:  BioPlex
ELMOD3
Tdark
Novelty:  0.33201025
p_int:  0.831783266
p_ni:  0.158804708
p_wrong:  0.009412025
Score:  0.519
Data Source:  BioPlex,STRINGDB
MCL1
Tchem
Novelty:  0.00046181
p_int:  0.76507468
p_ni:  0.231947892
p_wrong:  0.002977429
Score:  0.165
Data Source:  BioPlex,STRINGDB
RAB9B
Tbio
Family:  Enzyme
Novelty:  0.19952686
p_int:  0.751492998
p_ni:  0.243025491
p_wrong:  0.005481512
Score:  0.201
Data Source:  BioPlex,STRINGDB
TMEM37
Tbio
Family:  IC
Novelty:  0.00167645
Score:  0.771
Data Source:  STRINGDB
PI15
Tbio
Family:  Enzyme
Novelty:  0.02244161
Score:  0.621
Data Source:  STRINGDB
GPR162
Tbio
Family:  GPCR
Novelty:  0.14938549
Score:  0.602
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
2
3
92.7
2
3
0
1.1
83.7
platelet count
2
2
2
82.6
mean corpuscular volume
1
1
1
78.6
leukocyte count
1
1
1
71.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
92.7
0
1.1
83.7
platelet count
2
82.6
mean corpuscular volume
1
78.6
leukocyte count
1
71.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
aspartic peptidase retroviral like 1
470396
Macaque
aspartic peptidase retroviral like 1
701904
Mouse
MGI:1915105
67855
Dog
aspartic peptidase retroviral like 1 [Source:HGNC Symbol;Acc:HGNC:26321]
Horse
aspartic peptidase retroviral like 1
VGNC:15592
100060803
Species
Name
OMA
EggNOG
Inparanoid
Chimp
aspartic peptidase retroviral like 1
Macaque
aspartic peptidase retroviral like 1
Mouse
Dog
aspartic peptidase retroviral like 1 [Source:HGNC Symbol;Acc:HGNC:26321]
Horse
aspartic peptidase retroviral like 1
Publication Statistics
PubMed Score 39.05
PubMed score by year
PubTator Score 206.69
PubTator score by year
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Related Publications
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PMID
Year
Title