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Tbio
ASPM
Abnormal spindle-like microcephaly-associated protein

Protein Summary
Description
Involved in mitotic spindle regulation and coordination of mitotic processes. The function in regulating microtubule dynamics at spindle poles including spindle orientation, astral microtubule density and poleward microtubule flux seems to depend on the association with the katanin complex formed by KATNA1 and KATNB1. Enhances the microtubule lattice severing activity of KATNA1 by recruiting the katanin complex to microtubules. Can block microtubule minus-end growth and reversely this function can be enhanced by the katanin complex (PubMed:28436967). May have a preferential role in regulating neurogenesis. This gene is the human ortholog of the Drosophila melanogaster 'abnormal spindle' gene (asp), which is essential for normal mitotic spindle function in embryonic neuroblasts. Studies in mouse also suggest a role of this gene in mitotic spindle regulation, with a preferential role in regulating neurogenesis. Mutations in this gene are associated with microcephaly primary type 5. Multi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000294732
  • ENSP00000294732
  • ENSG00000066279
  • ENST00000367409
  • ENSP00000356379

Symbol
  • MCPH5
  • ASP
  • MCPH5
  • Calmbp1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.94
co-expressed gene
0.93
protein domain
0.85
biological process
0.83
small molecule perturbation
0.75


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 195.64   (req: < 5)
Gene RIFs: 59   (req: <= 3)
Antibodies: 63   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 195.64   (req: >= 5)
Gene RIFs: 59   (req: > 3)
Antibodies: 63   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (350)
DKK3
Tbio
Novelty:  0.00519275
p_int:  0.999917283
p_ni:  0.000082717
Score:  0.166
Data Source:  BioPlex,STRINGDB
DTNBP1
Tbio
Novelty:  0.00341619
p_int:  0.99778469
p_ni:  0.00221531
Data Source:  BioPlex
EID1
Tbio
Novelty:  0.02414732
p_int:  0.995545357
p_ni:  0.004454643
Data Source:  BioPlex
PPP6R2
Tbio
Family:  Enzyme
Novelty:  0.12886225
p_int:  0.995311483
p_ni:  0.004688517
Score:  0.191
Data Source:  BioPlex,STRINGDB
FSD2
Tbio
Novelty:  0.1302271
p_int:  0.995026152
p_ni:  0.004973848
Data Source:  BioPlex
PEX19
Tbio
Novelty:  0.00605342
p_int:  0.991417383
p_ni:  0.008582617
Score:  0.23
Data Source:  BioPlex,STRINGDB
NCAPH2
Tbio
Novelty:  0.12134933
p_int:  0.987210019
p_ni:  0.012789981
Score:  0.16
Data Source:  BioPlex,STRINGDB
RSPH6A
Tdark
Novelty:  0.03734897
p_int:  0.986377977
p_ni:  0.013622023
Data Source:  BioPlex
TEX13A
Tdark
Novelty:  1.13928013
p_int:  0.983045098
p_ni:  0.016954902
Data Source:  BioPlex
TP53INP1
Tbio
Novelty:  0.00407247
p_int:  0.976816774
p_ni:  0.023183226
Score:  0.175
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.7
87.8
sex hormone-binding globulin measurement
2
1
2
78.9
wellbeing measurement
2
1
2
5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.7
87.8
sex hormone-binding globulin measurement
2
78.9
wellbeing measurement
2
5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
abnormal spindle microtubule assembly
VGNC:52941
449566
Macaque
abnormal spindle microtubule assembly
711153
Mouse
MGI:1334448
12316
Rat
RGD:1307111
289054
Dog
abnormal spindle microtubule assembly
VGNC:38189
480009
Species
Name
OMA
EggNOG
Inparanoid
Chimp
abnormal spindle microtubule assembly
Macaque
abnormal spindle microtubule assembly
Mouse
Rat
Dog
abnormal spindle microtubule assembly
Publication Statistics
PubMed Score 195.64
PubMed score by year
PubTator Score 101.21
PubTator score by year
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Related Publications
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PMID
Year
Title