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Tdark
ASPHD2
Aspartate beta-hydroxylase domain-containing protein 2

Protein Summary
Description
May function as 2-oxoglutarate-dependent dioxygenase.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000215906
  • ENSP00000215906
  • ENSG00000128203
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.73
tissue sample
0.65
microRNA
0.64
tissue
0.57
transcription factor
0.54


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.6   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 103   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.6   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 103   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (32)
CLEC2B
Tbio
Novelty:  0.06581244
p_int:  0.999301223
p_ni:  0.000698773
p_wrong:  4e-9
Data Source:  BioPlex
GALNT6
Tbio
Family:  Enzyme
Novelty:  0.04627605
p_int:  0.998321453
p_ni:  0.001605329
p_wrong:  0.000073218
Score:  0.32
Data Source:  BioPlex,STRINGDB
C12orf49
Tdark
Novelty:  0.56030929
p_int:  0.998285652
p_ni:  0.001633704
p_wrong:  0.000080643
Data Source:  BioPlex
LYPD3
Tbio
Novelty:  0.03248533
p_int:  0.995797409
p_ni:  0.004202571
p_wrong:  2e-8
Data Source:  BioPlex
FAM20B
Tdark
Family:  Enzyme
Novelty:  0.07347685
p_int:  0.99456963
p_ni:  0.005430348
p_wrong:  2.1e-8
Score:  0.219
Data Source:  BioPlex,STRINGDB
GYPB
Tbio
Novelty:  0.00442195
p_int:  0.99418246
p_ni:  0.004658345
p_wrong:  0.001159195
Data Source:  BioPlex
ADAM32
Tdark
Family:  Enzyme
Novelty:  0.36071191
p_int:  0.993832482
p_ni:  0.006167503
p_wrong:  1.6e-8
Data Source:  BioPlex
GRPR
Tchem
Family:  GPCR
Novelty:  0.00282511
p_int:  0.993604233
p_ni:  0.006395745
p_wrong:  2.3e-8
Data Source:  BioPlex
DLK2
Tbio
Novelty:  0.06366405
p_int:  0.993441139
p_ni:  0.006499628
p_wrong:  0.000059233
Data Source:  BioPlex
ADAM2
Tbio
Family:  Enzyme
Novelty:  0.00586482
p_int:  0.991715374
p_ni:  0.008284615
p_wrong:  1.1e-8
Score:  0.169
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
1
1
1
55
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
1
55
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
aspartate beta-hydroxylase domain containing 2
VGNC:5226
747958
Macaque
aspartate beta-hydroxylase domain containing 2
712623
Mouse
MGI:1920148
72898
Rat
RGD:1306020
364948
Dog
aspartate beta-hydroxylase domain containing 2
VGNC:38188
612994
Species
Name
OMA
EggNOG
Inparanoid
Chimp
aspartate beta-hydroxylase domain containing 2
Macaque
aspartate beta-hydroxylase domain containing 2
Mouse
Rat
Dog
aspartate beta-hydroxylase domain containing 2
Publication Statistics
PubMed Score 0.60
PubMed score by year
PubTator Score 0.50
PubTator score by year
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Related Publications
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PMID
Year
Title