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Tbio
ASMTL
N-acetylserotonin O-methyltransferase-like protein

Protein Summary
Description
Unknown. The presence of the putative catalytic domain of S-adenosyl-L-methionine binding argues for a methyltransferase activity. The protein encoded by this gene has an N-terminus that is similar to the multicopy associated filamentation (maf) protein of Bacillus subtilis and to orfE of Escherichia coli, while the C-terminus is similar to N-acetylserotonin O-methyltransferase. This gene is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000381317
  • ENSP00000370718
  • ENSG00000169093
  • ENST00000381333
  • ENSP00000370734
  • ENST00000534940
  • ENSP00000446410

Symbol
  • ASTML
  • ASMTLX
  • ASMTLY
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
tissue
0.67
transcription factor
0.61
cell type or tissue
0.59
PubMedID
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.29   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 187   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.29   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 187   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (74)
TDO2
Tchem
Family:  Enzyme
Novelty:  0.00115832
p_int:  0.998130913
p_ni:  0.001869087
Score:  0.822
Data Source:  BioPlex,STRINGDB
WDR44
Tdark
Novelty:  0.02158824
p_int:  0.954960723
p_ni:  0.045039277
Score:  0.257
Data Source:  BioPlex,STRINGDB
KLHL40
Tbio
Novelty:  0.0432945
p_int:  0.947975593
p_ni:  0.052024407
Score:  0.193
Data Source:  BioPlex,STRINGDB
CFAP52
Tbio
Novelty:  0.23267809
p_int:  0.919039847
p_ni:  0.080960153
Score:  0.351
Data Source:  BioPlex,STRINGDB
SLC2A12
Tbio
Family:  Transporter
Novelty:  0.01455533
p_int:  0.911829954
p_ni:  0.088170046
Score:  0.216
Data Source:  BioPlex,STRINGDB
SLC25A6
Tchem
Family:  Transporter
Novelty:  0.0052748
Score:  0.776
Data Source:  STRINGDB
GTPBP6
Tdark
Novelty:  0.05036884
Score:  0.705
Data Source:  STRINGDB
RSAD1
Tdark
Novelty:  0.63344405
Score:  0.69
Data Source:  STRINGDB
TSFM
Tbio
Novelty:  0.00468811
Score:  0.676
Data Source:  STRINGDB
EEF1AKMT2
Tbio
Family:  Enzyme
Novelty:  0.13586312
Score:  0.673
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
1
1
70.2
lymphocyte percentage of leukocytes
1
1
1
60.5
lymphocyte count
1
1
1
57.8
mean reticulocyte volume
1
1
1
48.5
eosinophil count
1
1
1
37.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
70.2
lymphocyte percentage of leukocytes
1
60.5
lymphocyte count
1
57.8
mean reticulocyte volume
1
48.5
eosinophil count
1
37.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Dog
acetylserotonin O-methyltransferase like
609318
Cow
acetylserotonin O-methyltransferase like
VGNC:26215
508458
Opossum
acetylserotonin O-methyltransferase like
100010804
Platypus
acetylserotonin O-methyltransferase like [Source:HGNC Symbol;Acc:HGNC:751]
Chicken
acetylserotonin O-methyltransferase-like
CGNC:12508
769097
Species
Name
OMA
EggNOG
Inparanoid
Dog
acetylserotonin O-methyltransferase like
Cow
acetylserotonin O-methyltransferase like
Opossum
acetylserotonin O-methyltransferase like
Platypus
acetylserotonin O-methyltransferase like [Source:HGNC Symbol;Acc:HGNC:751]
Chicken
acetylserotonin O-methyltransferase-like
Publication Statistics
PubMed Score 5.29
PubMed score by year
PubTator Score 1.19
PubTator score by year
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Related Publications
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PMID
Year
Title