ASMTL
N-acetylserotonin O-methyltransferase-like protein
Protein Summary
Unknown. The presence of the putative catalytic domain of S-adenosyl-L-methionine binding argues for a methyltransferase activity. The protein encoded by this gene has an N-terminus that is similar to the multicopy associated filamentation (maf) protein of Bacillus subtilis and to orfE of Escherichia coli, while the C-terminus is similar to N-acetylserotonin O-methyltransferase. This gene is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
- ENST00000381317
- ENSP00000370718
- ENSG00000169093
- ENST00000381333
- ENSP00000370734
- ENST00000534940
- ENSP00000446410
- ASTML
- ASMTLX
- ASMTLY
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.85 | ||
tissue | 0.67 | ||
transcription factor | 0.61 | ||
cell type or tissue | 0.59 | ||
PubMedID | 0.58 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 5.29 (req: < 5)
Gene RIFs: 0 (req: <= 3)
Antibodies: 187 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 5.29 (req: >= 5)
Gene RIFs: 0 (req: > 3)
Antibodies: 187 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 2
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (74)
TDO2
Family: Enzyme
Novelty: 0.00115832
p_int: 0.998130913
p_ni: 0.001869087
Score: 0.822
Data Source: BioPlex,STRINGDB
WDR44
Novelty: 0.02158824
p_int: 0.954960723
p_ni: 0.045039277
Score: 0.257
Data Source: BioPlex,STRINGDB
KLHL40
Novelty: 0.0432945
p_int: 0.947975593
p_ni: 0.052024407
Score: 0.193
Data Source: BioPlex,STRINGDB
CFAP52
Novelty: 0.23267809
p_int: 0.919039847
p_ni: 0.080960153
Score: 0.351
Data Source: BioPlex,STRINGDB
SLC2A12
Family: Transporter
Novelty: 0.01455533
p_int: 0.911829954
p_ni: 0.088170046
Score: 0.216
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (3)
Functions (2)
Components (1)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | InterPro | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (9)
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mean corpuscular volume | 1 | 1 | 1 | 70.2 | |||||
lymphocyte percentage of leukocytes | 1 | 1 | 1 | 60.5 | |||||
lymphocyte count | 1 | 1 | 1 | 57.8 | |||||
mean reticulocyte volume | 1 | 1 | 1 | 48.5 | |||||
eosinophil count | 1 | 1 | 1 | 37.6 | |||||
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mean corpuscular volume | 1 | 70.2 | |||||
lymphocyte percentage of leukocytes | 1 | 60.5 | |||||
lymphocyte count | 1 | 57.8 | |||||
mean reticulocyte volume | 1 | 48.5 | |||||
eosinophil count | 1 | 37.6 | |||||
Find similar targets by:
IDG Resources
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Dog | acetylserotonin O-methyltransferase like | 609318 | ||||||
Cow | acetylserotonin O-methyltransferase like | VGNC:26215 | 508458 | |||||
Opossum | acetylserotonin O-methyltransferase like | 100010804 | ||||||
Platypus | acetylserotonin O-methyltransferase like [Source:HGNC Symbol;Acc:HGNC:751] | |||||||
Chicken | acetylserotonin O-methyltransferase-like | CGNC:12508 | 769097 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Dog | acetylserotonin O-methyltransferase like | |||||
Cow | acetylserotonin O-methyltransferase like | |||||
Opossum | acetylserotonin O-methyltransferase like | |||||
Platypus | acetylserotonin O-methyltransferase like [Source:HGNC Symbol;Acc:HGNC:751] | |||||
Chicken | acetylserotonin O-methyltransferase-like | |||||
Publication Statistics
PubMed Score 5.29
PubMed score by year
PubTator Score 1.19
PubTator score by year
Related Publications
Text Mined References (11)
Items per page:
0 of 0
PMID | Year | Title |
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