You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
ASCL3
Achaete-scute homolog 3

Protein Summary
Description
Transcriptional repressor. Inhibits myogenesis (By similarity). Basic helix-loop-helix transcription factors, such as ASCL3, are essential for the determination of cell fate and the development and differentiation of numerous tissues (Jonsson et al., 2004 [PubMed 15475265]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000531618
  • ENSP00000435770
  • ENSG00000176009

Symbol
  • BHLHA42
  • HASH3
  • SGN1
  • SGN1
  • HASH3
  • bHLHa42
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.84
cell type or tissue
0.76
tissue sample
0.56
gene perturbation
0.48
disease perturbation
0.43


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.8   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 86   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.8   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 86   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (27)
TCF3
Tbio
Family:  TF
Novelty:  0.00112675
Score:  0.861
Data Source:  STRINGDB
ID1
Tbio
Family:  TF
Novelty:  0.00151069
Score:  0.842
Data Source:  STRINGDB
MYOD1
Tbio
Family:  TF
Novelty:  0.00053412
Score:  0.737
Data Source:  STRINGDB
NEUROD4
Tbio
Family:  TF
Novelty:  0.03787483
Score:  0.691
Data Source:  STRINGDB
ACSL6
Tbio
Family:  Enzyme
Novelty:  0.0100317
Score:  0.614
Data Source:  STRINGDB
FOXN4
Tbio
Family:  TF
Novelty:  0.04762528
Score:  0.584
Data Source:  STRINGDB
ACBD6
Tbio
Novelty:  0.3555227
Score:  0.564
Data Source:  STRINGDB
PET100
Tbio
Novelty:  0.17104943
Score:  0.556
Data Source:  STRINGDB
ACSL4
Tbio
Family:  Enzyme
Novelty:  0.0072645
Score:  0.551
Data Source:  STRINGDB
ACSL3
Tbio
Family:  Enzyme
Novelty:  0.01772336
Score:  0.539
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (9)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
2
5
93.9
alkaline phosphatase measurement
2
2
1
9.9
89.3
hematocrit
5
5
5
88.7
hemoglobin measurement
4
4
4
88.4
red blood cell density measurement
1
1
1
72.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
5
93.9
alkaline phosphatase measurement
1
9.9
89.3
hematocrit
5
88.7
hemoglobin measurement
4
88.4
red blood cell density measurement
1
72.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
achaete-scute family bHLH transcription factor 3
705072
Mouse
MGI:1928820
56787
Dog
achaete-scute family bHLH transcription factor 3
VGNC:38175
100686513
Opossum
achaete-scute family bHLH transcription factor 3
100029514
Platypus
achaete-scute family bHLH transcription factor 3
100078656
Species
Name
OMA
EggNOG
Inparanoid
Macaque
achaete-scute family bHLH transcription factor 3
Mouse
Dog
achaete-scute family bHLH transcription factor 3
Opossum
achaete-scute family bHLH transcription factor 3
Platypus
achaete-scute family bHLH transcription factor 3
Publication Statistics
PubMed Score 20.80
PubMed score by year
PubTator Score 16.40
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title