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Tbio
ASCL2
Achaete-scute homolog 2

Protein Summary
Description
AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system. This gene is a member of the basic helix-loop-helix (BHLH) family of transcription factors. It activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. Involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000331289
  • ENSP00000332293
  • ENSG00000183734

Symbol
  • BHLHA45
  • HASH2
  • ASH2
  • HASH2
  • MASH2
  • bHLHa45
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.84
cell type or tissue
0.83
biological process
0.79
PubMedID
0.72
transcription factor binding site profile
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 133.45   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 209   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 133.45   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 209   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (62)
PHLDA2
Tbio
Novelty:  0.01847579
Score:  0.866
Data Source:  STRINGDB
CDX2
Tbio
Family:  TF
Novelty:  0.00081636
Score:  0.783
Data Source:  STRINGDB
GCM1
Tbio
Family:  TF
Novelty:  0.01067683
Score:  0.769
Data Source:  STRINGDB
LGR5
Tbio
Family:  GPCR
Novelty:  0.00105035
Score:  0.738
Data Source:  STRINGDB
OLFM4
Tbio
Novelty:  0.01048505
Score:  0.732
Data Source:  STRINGDB
CXCR5
Tchem
Family:  GPCR
Novelty:  0.00214886
Score:  0.719
Data Source:  STRINGDB
KCNQ1
Tclin
Family:  IC
Novelty:  0.0008956
Score:  0.687
Data Source:  STRINGDB
SLC22A18
Tbio
Family:  Transporter
Novelty:  0.0189809
Score:  0.647
Data Source:  STRINGDB
NOTCH1
Tchem
Novelty:  0.00012547
Score:  0.643
Data Source:  STRINGDB
LRIG1
Tbio
Novelty:  0.01078663
Score:  0.633
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (25)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (33)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
type 2 diabetes mellitus
8
5
2
1.1
99.3
6
4
0
1.2
98.2
type 1 diabetes mellitus
2
2
1
1.2
93.6
3
3
0
1.2
81
IGF-1 measurement
1
2
2
74.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
type 2 diabetes mellitus
2
1.1
99.3
0
1.2
98.2
type 1 diabetes mellitus
1
1.2
93.6
0
1.2
81
IGF-1 measurement
2
74.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
achaete-scute family bHLH transcription factor 2
721175
Mouse
MGI:96920
17173
Rat
RGD:2159
24209
Dog
achaete-scute family bHLH transcription factor 2
VGNC:38174
483666
Cow
achaete-scute family bHLH transcription factor 2
VGNC:26207
664650
Species
Name
OMA
EggNOG
Inparanoid
Macaque
achaete-scute family bHLH transcription factor 2
Mouse
Rat
Dog
achaete-scute family bHLH transcription factor 2
Cow
achaete-scute family bHLH transcription factor 2
Publication Statistics
PubMed Score 133.45
PubMed score by year
PubTator Score 47.45
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title