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Tbio
ASCC3
Activating signal cointegrator 1 complex subunit 3

Protein Summary
Description
3'-5' DNA helicase involved in repair of alkylated DNA. Promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3, enabling ALKBH3 to process alkylated N3-methylcytosine (3mC) within double-stranded regions (PubMed:22055184). Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation (PubMed:12077347). This gene encodes a protein that belongs to a family of helicases that are involved in the ATP-dependent unwinding of nucleic acid duplexes. The encoded protein is the largest subunit of the activating signal cointegrator 1 complex that is involved in DNA repair and resistance to alkylation damage. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369143
  • ENSP00000358139
  • ENSG00000112249
  • ENST00000369162
  • ENSP00000358159
  • ENST00000522650
  • ENSP00000430769

Symbol
  • HELIC1
  • RNAH
  • HELIC1
  • ASC1p200
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
protein domain
0.97
virus perturbation
0.95
histone modification site profile
0.77
microRNA
0.75


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.23   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 79   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.23   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 79   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (198)
ASCC1
Tbio
Novelty:  0.1280098
p_int:  0.999998287
p_ni:  0.000001713
Score:  0.992
Data Source:  BioPlex,Reactome,STRINGDB
ASCC2
Tbio
Novelty:  0.12261896
p_int:  0.999992009
p_ni:  0.000007991
Score:  0.995
Data Source:  BioPlex,Reactome,STRINGDB
NOG
Tbio
Novelty:  0.0010373
p_int:  0.998259949
p_ni:  0.001740051
Data Source:  BioPlex
ALKBH3
Tchem
Family:  Enzyme
Novelty:  0.02040675
p_int:  0.997859221
p_ni:  0.002140779
Score:  0.996
Data Source:  BioPlex,Reactome,STRINGDB
RPS13
Tbio
Novelty:  0.0019983
p_int:  0.990597257
p_ni:  0.009402743
Data Source:  BioPlex
HCCS
Tbio
Family:  Enzyme
Novelty:  0.0022585
p_int:  0.983399878
p_ni:  0.016600122
Score:  0.173
Data Source:  BioPlex,STRINGDB
TTC9C
Tdark
Novelty:  0.85949913
p_int:  0.982992626
p_ni:  0.017007374
Data Source:  BioPlex
DGKZ
Tchem
Family:  Enzyme
Novelty:  0.01312044
p_int:  0.903027347
p_ni:  0.096972653
Data Source:  BioPlex
TRAK1
Tbio
Novelty:  0.03561577
p_int:  0.852378642
p_ni:  0.147621358
Data Source:  BioPlex
ZNF263
Tbio
Family:  TF
Novelty:  0.098799
p_int:  0.813640504
p_ni:  0.186359496
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
ALKBH3 mediated reversal of alkylation damage (R-HSA-112126)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ALKBH3 mediated reversal of alkylation damage
Reactome
DNA Damage Reversal
Reactome
DNA Repair
Reactome
Reversal of alkylation damage by DNA dioxygenases
Name
Explore in Pharos
Explore in Source
ALKBH3 mediated reversal of alkylation damage
DNA Damage Reversal
DNA Repair
Reversal of alkylation damage by DNA dioxygenases
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
3
1
1
76.4
body mass index
2
2
2
61.8
insomnia measurement
2
2
0
1
61.8
hemoglobin measurement
1
1
1
58.4
smoking status measurement
1
1
1
56.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
76.4
body mass index
2
61.8
insomnia measurement
0
1
61.8
hemoglobin measurement
1
58.4
smoking status measurement
1
56.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
activating signal cointegrator 1 complex subunit 3
VGNC:11034
462898
Macaque
activating signal cointegrator 1 complex subunit 3
695429
Mouse
MGI:1925237
77987
Rat
RGD:1307995
309887
Dog
activating signal cointegrator 1 complex subunit 3
VGNC:38172
475008
Species
Name
OMA
EggNOG
Inparanoid
Chimp
activating signal cointegrator 1 complex subunit 3
Macaque
activating signal cointegrator 1 complex subunit 3
Mouse
Rat
Dog
activating signal cointegrator 1 complex subunit 3
Publication Statistics
PubMed Score 9.23
PubMed score by year
PubTator Score 4.69
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title