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Tdark
ASB8
Ankyrin repeat and SOCS box protein 8

Protein Summary
Description
May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000317697
  • ENSP00000320893
  • ENSG00000177981
  • ENST00000536549
  • ENSP00000445622

Symbol
  • PP14212
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.84
transcription factor perturbation
0.8
disease perturbation
0.79
histone modification site profile
0.76
transcription factor binding site profile
0.64


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.86   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 163   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.86   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 163   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (319)
CUL5
Tbio
Novelty:  0.00792494
p_int:  0.999999994
p_ni:  6e-9
Score:  0.93
Data Source:  BioPlex,STRINGDB
IARS2
Tchem
Family:  Enzyme
Novelty:  0.00854621
p_int:  0.999999749
p_ni:  2.51e-7
Score:  0.195
Data Source:  BioPlex,STRINGDB
HIF1AN
Tbio
Novelty:  0.00861018
p_int:  0.99999735
p_ni:  0.00000265
Score:  0.286
Data Source:  BioPlex,STRINGDB
RNF7
Tbio
Novelty:  0.02532658
p_int:  0.999996971
p_ni:  0.000002075
p_wrong:  9.54e-7
Score:  0.906
Data Source:  BioPlex,STRINGDB
NPAT
Tbio
Novelty:  0.01063979
p_int:  0.987800604
p_ni:  0.009640143
p_wrong:  0.002559252
Score:  0.295
Data Source:  BioPlex,STRINGDB
TRIM11
Tbio
Family:  Enzyme
Novelty:  0.02243955
p_int:  0.972893537
p_ni:  0.027106462
p_wrong:  1e-9
Score:  0.921
Data Source:  BioPlex,STRINGDB
AMBRA1
Tbio
Novelty:  0.01626687
p_int:  0.800286413
p_ni:  0.199713587
Score:  0.245
Data Source:  BioPlex,STRINGDB
RUFY3
Tbio
Novelty:  0.1517817
p_int:  0.755023682
p_ni:  0.244976288
p_wrong:  3e-8
Score:  0.187
Data Source:  BioPlex,STRINGDB
ELOB
Tbio
Novelty:  0.01315739
Score:  0.952
Data Source:  STRINGDB
ELOC
Tbio
Novelty:  0.00964847
Score:  0.947
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (4)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
3
7
7
97.1
hemoglobin measurement
3
3
4
97.1
hematocrit
3
2
4
95.1
red blood cell density measurement
1
1
1
83.1
mean corpuscular volume
1
1
1
73.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
7
97.1
hemoglobin measurement
4
97.1
hematocrit
4
95.1
red blood cell density measurement
1
83.1
mean corpuscular volume
1
73.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ankyrin repeat and SOCS box containing 8
VGNC:4937
466969
Macaque
ankyrin repeat and SOCS box containing 8
705435
Mouse
MGI:1925791
78541
Rat
RGD:1309246
315287
Dog
ankyrin repeat and SOCS box containing 8
VGNC:38168
486587
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ankyrin repeat and SOCS box containing 8
Macaque
ankyrin repeat and SOCS box containing 8
Mouse
Rat
Dog
ankyrin repeat and SOCS box containing 8
Publication Statistics
PubMed Score 2.86
PubMed score by year
PubTator Score 1.70
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title