ASB7
Ankyrin repeat and SOCS box protein 7
Protein Summary
Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The protein encoded by this gene belongs to a family of ankyrin repeat proteins that, along with four other protein families, contains a C-terminal SOCS box motif. Growing evidence suggests that the SOCS box acts as a bridge between specific substrate-binding domains and the more generic proteins that comprise a large family of E3 ubiquitin protein ligases. In this way, SOCS box containing proteins may regulate protein turnover by targeting proteins for polyubiquination and, therefore, for proteasome-mediated degradation. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
- ENST00000332783
- ENSP00000328327
- ENSG00000183475
- ENST00000343276
- ENSP00000339819
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
virus perturbation | 1 | ||
histone modification site profile | 0.82 | ||
microRNA | 0.77 | ||
cell type or tissue | 0.65 | ||
transcription factor binding site profile | 0.64 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 4.91 (req: < 5)
Gene RIFs: 2 (req: <= 3)
Antibodies: 142 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 4.91 (req: >= 5)
Gene RIFs: 2 (req: > 3)
Antibodies: 142 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (368)
RNF7
Novelty: 0.02532658
p_int: 0.999999992
p_ni: 8e-9
Score: 0.955
Data Source: BioPlex,STRINGDB
TRIP11
Novelty: 0.03011344
p_int: 0.999999892
p_ni: 1.08e-7
Score: 0.192
Data Source: BioPlex,STRINGDB
CUL5
Novelty: 0.00792494
p_int: 0.999999818
p_ni: 1.82e-7
Score: 0.958
Data Source: BioPlex,STRINGDB
ADAM33
Family: Enzyme
Novelty: 0.00584097
p_int: 0.999998841
p_ni: 0.000001159
Data Source: BioPlex
HMBOX1
Family: TF
Novelty: 0.02455652
p_int: 0.999996221
p_ni: 0.000003778
p_wrong: 1e-9
Score: 0.197
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (8)
Reactome (7)
UniProt (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Adaptive Immune System | ||||
Reactome | Antigen processing: Ubiquitination & Proteasome degradation | ||||
Reactome | Class I MHC mediated antigen processing & presentation | ||||
Reactome | Immune System | ||||
Reactome | Metabolism of proteins | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Adaptive Immune System | ||||
Antigen processing: Ubiquitination & Proteasome degradation | ||||
Class I MHC mediated antigen processing & presentation | ||||
Immune System | ||||
Metabolism of proteins | ||||
Viral Interactions (0)
Gene Ontology Terms (4)
Components (1)
Processes (3)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | Reactome | |||
Disease Associations ()
GWAS Traits (7)
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
cup-to-disc ratio measurement | 4 | 3 | 5 | 84.9 | |||||
chronotype measurement | 2 | 2 | 1 | 1 | 76.2 | ||||
optic cup area measurement | 3 | 3 | 3 | 57.6 | |||||
cotinine glucuronidation measurement | 1 | 1 | 1 | 17.8 | |||||
chin morphology measurement | 1 | 1 | 0 | 1.1 | 11.5 | ||||
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
cup-to-disc ratio measurement | 5 | 84.9 | |||||
chronotype measurement | 1 | 1 | 76.2 | ||||
optic cup area measurement | 3 | 57.6 | |||||
cotinine glucuronidation measurement | 1 | 17.8 | |||||
chin morphology measurement | 0 | 1.1 | 11.5 | ||||
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | ankyrin repeat and SOCS box containing 7 | VGNC:11822 | 467845 | |||||
Macaque | ankyrin repeat and SOCS box containing 7 | 693956 | ||||||
Mouse | MGI:2152835 | 117589 | ||||||
Rat | RGD:1305154 | 365277 | ||||||
Dog | ankyrin repeat and SOCS box containing 7 | VGNC:38167 | 488707 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | ankyrin repeat and SOCS box containing 7 | |||||
Macaque | ankyrin repeat and SOCS box containing 7 | |||||
Mouse | ||||||
Rat | ||||||
Dog | ankyrin repeat and SOCS box containing 7 | |||||
Publication Statistics
PubMed Score 4.91
PubMed score by year
PubTator Score 1.09
PubTator score by year
Related Publications
Text Mined References (11)
GeneRif Annotations (2)
Items per page:
0 of 0
PMID | Year | Title |
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