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Tdark
ASB18
Ankyrin repeat and SOCS box protein 18

Protein Summary
Description
May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and a SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. [provided by RefSeq, Feb 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000409749
  • ENSP00000386532
  • ENSG00000182177
  • ENST00000645891
  • ENSP00000496134

Symbol
  • ASB-18
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.85
cell type or tissue
0.68
tissue
0.59
cell line
0.58
cellular component
0.52


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.75   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 10   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.75   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 10   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (301)
ASB17
Tbio
Novelty:  0.0979661
Score:  0.956
Data Source:  STRINGDB
CUL5
Tbio
Novelty:  0.00792494
Score:  0.954
Data Source:  STRINGDB
HERC4
Tbio
Family:  Enzyme
Novelty:  0.06392683
Score:  0.947
Data Source:  STRINGDB
CISH
Tbio
Novelty:  0.00145893
Score:  0.937
Data Source:  STRINGDB
TRIP12
Tbio
Family:  Enzyme
Novelty:  0.03433452
Score:  0.937
Data Source:  STRINGDB
RNF7
Tbio
Novelty:  0.02532658
Score:  0.937
Data Source:  STRINGDB
CUL2
Tbio
Novelty:  0.00512916
Score:  0.936
Data Source:  STRINGDB
NEURL2
Tbio
Novelty:  0.29029379
Score:  0.933
Data Source:  STRINGDB
ASB1
Tdark
Novelty:  0.0931554
Score:  0.932
Data Source:  STRINGDB
ASB14
Tdark
Novelty:  1.75017246
Score:  0.931
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (4)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
6
4
5
1.1
93.7
educational attainment
2
3
2
43
88.2
Hemifacial microsomia
1
1
0
1.4
78
smoking status measurement
1
1
1
16.8
mathematical ability
2
1
2
13.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
5
1.1
93.7
educational attainment
2
43
88.2
Hemifacial microsomia
0
1.4
78
smoking status measurement
1
16.8
mathematical ability
2
13.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ankyrin repeat and SOCS box containing 18
VGNC:95
470690
Mouse
MGI:2655109
208372
Rat
RGD:1310850
316614
Dog
ankyrin repeat and SOCS box containing 18
VGNC:38162
486175
Cow
ankyrin repeat and SOCS box containing 18
VGNC:26195
100141009
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ankyrin repeat and SOCS box containing 18
Mouse
Rat
Dog
ankyrin repeat and SOCS box containing 18
Cow
ankyrin repeat and SOCS box containing 18
Publication Statistics
PubMed Score 0.75
PubMed score by year
PubTator Score 0.14
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title