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Tbio
ASB17
Ankyrin repeat and SOCS box protein 17

Protein Summary
Description
May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000284142
  • ENSP00000284142
  • ENSG00000154007

Symbol
  • Asb-17
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.98
cellular component
0.75
cell type or tissue
0.7
cell line
0.52
protein domain
0.41


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.62   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 137   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.62   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 137   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (301)
ASB2
Tbio
Novelty:  0.02852942
Score:  0.985
Data Source:  STRINGDB
ASB9
Tbio
Novelty:  0.18287435
Score:  0.966
Data Source:  STRINGDB
ASB18
Tdark
Novelty:  1.29585637
Score:  0.956
Data Source:  STRINGDB
ASB4
Tbio
Novelty:  0.09903118
Score:  0.954
Data Source:  STRINGDB
ASB1
Tdark
Novelty:  0.0931554
Score:  0.949
Data Source:  STRINGDB
NEURL2
Tdark
Novelty:  0.29029379
Score:  0.923
Data Source:  STRINGDB
ELOB
Tbio
Novelty:  0.01315739
Score:  0.912
Data Source:  STRINGDB
TRIM71
Tbio
Family:  Enzyme
Novelty:  0.01164618
Score:  0.907
Data Source:  STRINGDB
CISH
Tbio
Novelty:  0.00145893
Score:  0.906
Data Source:  STRINGDB
ELOC
Tbio
Novelty:  0.00964847
Score:  0.904
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (4)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum metabolite measurement
1
1
4
39.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum metabolite measurement
4
39.6
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ankyrin repeat and SOCS box containing 17
VGNC:446
456957
Mouse
MGI:1914022
66772
Rat
RGD:1586533
687364
Dog
ankyrin repeat and SOCS box containing 17
VGNC:38161
403539
Horse
ankyrin repeat and SOCS box containing 17
VGNC:15569
100067240
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ankyrin repeat and SOCS box containing 17
Mouse
Rat
Dog
ankyrin repeat and SOCS box containing 17
Horse
ankyrin repeat and SOCS box containing 17
Publication Statistics
PubMed Score 10.62
PubMed score by year
PubTator Score 0.75
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title