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Tdark
ASB1
Ankyrin repeat and SOCS box protein 1

Protein Summary
Description
May play a role in testis development (By similarity). Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The protein encoded by this gene contains an ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, targeting them for ubiquitination and degradation. [provided by RefSeq, Aug 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264607
  • ENSP00000264607
  • ENSG00000065802

Symbol
  • KIAA1146
  • ASB-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.86
disease perturbation
0.83
kinase perturbation
0.81
transcription factor perturbation
0.8
histone modification site profile
0.79


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.51   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 29   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.51   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 29   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (327)
CUL5
Tbio
Novelty:  0.00792494
p_int:  0.999999991
p_ni:  5e-9
p_wrong:  4e-9
Score:  0.971
Data Source:  BioPlex,STRINGDB
RNF7
Tbio
Novelty:  0.02532658
p_int:  0.999999977
p_ni:  2.3e-8
Score:  0.963
Data Source:  BioPlex,STRINGDB
CASQ2
Tbio
Novelty:  0.00775794
p_int:  0.999997594
p_ni:  0.000002403
p_wrong:  3e-9
Score:  0.21
Data Source:  BioPlex,STRINGDB
PPP1R12B
Tbio
Family:  Enzyme
Novelty:  0.0424259
p_int:  0.999992337
p_ni:  0.000007072
p_wrong:  5.91e-7
Data Source:  BioPlex
TSHB
Tbio
Novelty:  0.00194403
p_int:  0.999764358
p_ni:  0.000056837
p_wrong:  0.000178805
Score:  0.237
Data Source:  BioPlex,STRINGDB
KCTD7
Tbio
Novelty:  0.04309568
Score:  0.971
Data Source:  STRINGDB
CISH
Tbio
Novelty:  0.00145893
Score:  0.962
Data Source:  STRINGDB
ASB6
Tdark
Novelty:  0.32074223
Score:  0.957
Data Source:  STRINGDB
ELOB
Tbio
Novelty:  0.01315739
Score:  0.952
Data Source:  STRINGDB
ELOC
Tbio
Novelty:  0.00964847
Score:  0.951
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
3
5
3
1.1
96.6
circadian rhythm
5
4
3
1.1
79
intraocular pressure measurement
3
3
4
59
forced expiratory volume
1
1
1
56
eye measurement
1
1
1
54.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
3
1.1
96.6
circadian rhythm
3
1.1
79
intraocular pressure measurement
4
59
forced expiratory volume
1
56
eye measurement
1
54.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
ankyrin repeat and SOCS box containing 1
696716
Mouse
MGI:1929735
65247
Rat
RGD:1310760
316628
Dog
ankyrin repeat and SOCS box containing 1 [Source:HGNC Symbol;Acc:HGNC:16011]
Horse
ankyrin repeat and SOCS box containing 1
VGNC:15561
100059795
Species
Name
OMA
EggNOG
Inparanoid
Macaque
ankyrin repeat and SOCS box containing 1
Mouse
Rat
Dog
ankyrin repeat and SOCS box containing 1 [Source:HGNC Symbol;Acc:HGNC:16011]
Horse
ankyrin repeat and SOCS box containing 1
Publication Statistics
PubMed Score 11.51
PubMed score by year
PubTator Score 6.23
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title