Tdark ASB1 Ankyrin repeat and SOCS box protein 1

Protein Summary

Description

May play a role in testis development (By similarity). Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The protein encoded by this gene contains an ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, targeting them for ubiquitination and degradation. [provided by RefSeq, Aug 2016]

Uniprot Accession IDs

• Q9Y576
• A6NL50
• Q4ZG29
• Q9ULS4
• ASB-1

Gene Name

• ASB1

Ensembl ID

• ENST00000264607
• ENSP00000264607
• ENSG00000065802

Symbol

• KIAA1146
• ASB-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.86
disease perturbation	0.83
kinase perturbation	0.81
transcription factor perturbation	0.8
histone modification site profile	0.79

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.11   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 29   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.11   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 29   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0