ASB1
Ankyrin repeat and SOCS box protein 1
Protein Summary
May play a role in testis development (By similarity). Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The protein encoded by this gene contains an ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, targeting them for ubiquitination and degradation. [provided by RefSeq, Aug 2016]
- ENST00000264607
- ENSP00000264607
- ENSG00000065802
- KIAA1146
- ASB-1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor binding site profile | 0.86 | ||
disease perturbation | 0.83 | ||
kinase perturbation | 0.81 | ||
transcription factor perturbation | 0.8 | ||
histone modification site profile | 0.79 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 11.51 (req: < 5)
Gene RIFs: 2 (req: <= 3)
Antibodies: 29 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 11.51 (req: >= 5)
Gene RIFs: 2 (req: > 3)
Antibodies: 29 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (327)
CUL5
Novelty: 0.00792494
p_int: 0.999999991
p_ni: 5e-9
p_wrong: 4e-9
Score: 0.971
Data Source: BioPlex,STRINGDB
RNF7
Novelty: 0.02532658
p_int: 0.999999977
p_ni: 2.3e-8
Score: 0.963
Data Source: BioPlex,STRINGDB
CASQ2
Novelty: 0.00775794
p_int: 0.999997594
p_ni: 0.000002403
p_wrong: 3e-9
Score: 0.21
Data Source: BioPlex,STRINGDB
PPP1R12B
Family: Enzyme
Novelty: 0.0424259
p_int: 0.999992337
p_ni: 0.000007072
p_wrong: 5.91e-7
Data Source: BioPlex
TSHB
Novelty: 0.00194403
p_int: 0.999764358
p_ni: 0.000056837
p_wrong: 0.000178805
Score: 0.237
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (8)
Reactome (7)
UniProt (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Adaptive Immune System | ||||
Reactome | Antigen processing: Ubiquitination & Proteasome degradation | ||||
Reactome | Class I MHC mediated antigen processing & presentation | ||||
Reactome | Immune System | ||||
Reactome | Metabolism of proteins | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Adaptive Immune System | ||||
Antigen processing: Ubiquitination & Proteasome degradation | ||||
Class I MHC mediated antigen processing & presentation | ||||
Immune System | ||||
Metabolism of proteins | ||||
Viral Interactions (0)
Gene Ontology Terms (7)
Components (2)
Processes (5)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Traceable Author Statement (TAS) | Reactome | |||
Disease Associations (null)
GWAS Traits (9)
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
chronotype measurement | 3 | 5 | 3 | 1.1 | 96.6 | ||||
circadian rhythm | 5 | 4 | 3 | 1.1 | 79 | ||||
intraocular pressure measurement | 3 | 3 | 4 | 59 | |||||
forced expiratory volume | 1 | 1 | 1 | 56 | |||||
eye measurement | 1 | 1 | 1 | 54.4 | |||||
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
chronotype measurement | 3 | 1.1 | 96.6 | ||||
circadian rhythm | 3 | 1.1 | 79 | ||||
intraocular pressure measurement | 4 | 59 | |||||
forced expiratory volume | 1 | 56 | |||||
eye measurement | 1 | 54.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | ankyrin repeat and SOCS box containing 1 | 696716 | ||||||
Mouse | MGI:1929735 | 65247 | ||||||
Rat | RGD:1310760 | 316628 | ||||||
Dog | ankyrin repeat and SOCS box containing 1 [Source:HGNC Symbol;Acc:HGNC:16011] | |||||||
Horse | ankyrin repeat and SOCS box containing 1 | VGNC:15561 | 100059795 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | ankyrin repeat and SOCS box containing 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | ankyrin repeat and SOCS box containing 1 [Source:HGNC Symbol;Acc:HGNC:16011] | |||||
Horse | ankyrin repeat and SOCS box containing 1 | |||||
Publication Statistics
PubMed Score 11.51
PubMed score by year
PubTator Score 6.23
PubTator score by year
Related Publications
Text Mined References (13)
GeneRif Annotations (2)
Items per page:
0 of 0
PMID | Year | Title |
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