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Tbio
ASAP3
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3

Protein Summary
Description
Promotes cell proliferation. This gene encodes a member of a subfamily of ADP-ribosylation factor(Arf) GTPase-activating proteins that contain additional ankyrin repeat and pleckstrin homology domains. The Arf GAP domain of this protein catalyzes the hydrolysis of GTP bound to Arf proteins. The encoded protein promotes cell differentiation and migration and has been implicated in cancer cell invasion. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000336689
  • ENSP00000338769
  • ENSG00000088280
  • ENST00000437606
  • ENSP00000408826
  • ENST00000495646
  • ENSP00000436150
  • ENST00000634513
  • ENSP00000488934
  • ENSG00000282854
  • ENST00000634561
  • ENSP00000488946
  • ENST00000635198
  • ENSP00000488953

Symbol
  • DDEFL1
  • UPLC1
  • ACAP4
  • UPLC1
  • CENTB6
  • DDEFL1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
histone modification site profile
0.81
cell type or tissue
0.65
tissue sample
0.6
transcription factor binding site profile
0.57


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.4   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 155   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.4   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 155   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (25)
ASAP1
Tbio
Novelty:  0.00913771
p_int:  0.999999656
p_ni:  3.44e-7
Score:  0.84
Data Source:  BioPlex,STRINGDB
ASAP2
Tbio
Novelty:  0.02744569
p_int:  0.999999486
p_ni:  5.14e-7
Score:  0.84
Data Source:  BioPlex,STRINGDB
HSPA1A
Tchem
Novelty:  0.00069195
p_int:  0.99999913
p_ni:  8.7e-7
Score:  0.278
Data Source:  BioPlex,STRINGDB
MYORG
Tbio
Family:  Enzyme
Novelty:  0.0478246
p_int:  0.999234648
p_ni:  0.000765352
Score:  0.189
Data Source:  BioPlex,STRINGDB
ACAD11
Tbio
Family:  Enzyme
Novelty:  0.22908145
p_int:  0.998968752
p_ni:  0.001031248
Score:  0.16
Data Source:  BioPlex,STRINGDB
BACH1
Tbio
Family:  TF
Novelty:  0.04011328
p_int:  0.970204136
p_ni:  0.029795863
p_wrong:  1e-9
Score:  0.179
Data Source:  BioPlex,STRINGDB
ELP2
Tbio
Novelty:  0.03034629
p_int:  0.946793711
p_ni:  0.053206289
Score:  0.202
Data Source:  BioPlex,STRINGDB
GOLGA2
Tbio
Novelty:  0.00544771
p_int:  0.868788862
p_ni:  0.131211137
Score:  0.186
Data Source:  BioPlex,STRINGDB
ARF6
Tbio
Family:  Enzyme
Novelty:  0.00278138
Score:  0.952
Data Source:  STRINGDB
IKBKG
Tbio
Family:  Kinase
Novelty:  0.0006149
Score:  0.667
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (64)
Items per page:
1 – 5 of 64
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
6
5
5
7.8
92.8
glomerular filtration rate
6
5
5
7.8
92.8
red blood cell distribution width
4
2
4
92.5
red blood cell distribution width
4
2
4
92.5
serum gamma-glutamyl transferase measurement
2
2
2
89.4
Items per page:
1 – 5 of 64
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
5
7.8
92.8
glomerular filtration rate
5
7.8
92.8
red blood cell distribution width
4
92.5
red blood cell distribution width
4
92.5
serum gamma-glutamyl transferase measurement
2
89.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2684986
230837
Rat
RGD:1593929
684122
Horse
ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
VGNC:15560
100071599
Cow
ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
VGNC:54406
523797
Pig
ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
100626125
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Horse
ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
Cow
ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
Pig
ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
Publication Statistics
PubMed Score 19.40
PubMed score by year
PubTator Score 11.65
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title