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Tbio
ASAP2
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2

Protein Summary
Description
Activates the small GTPases ARF1, ARF5 and ARF6. Regulates the formation of post-Golgi vesicles and modulates constitutive secretion. Modulates phagocytosis mediated by Fc gamma receptor and ARF6. Modulates PXN recruitment to focal contacts and cell migration. This gene encodes a multidomain protein containing an N-terminal alpha-helical region with a coiled-coil motif, followed by a pleckstrin homology (PH) domain, an Arf-GAP domain, an ankyrin homology region, a proline-rich region, and a C-terminal Src homology 3 (SH3) domain. The protein localizes in the Golgi apparatus and at the plasma membrane, where it colocalizes with protein tyrosine kinase 2-beta (PYK2). The encoded protein forms a stable complex with PYK2 in vivo. This interaction appears to be mediated by binding of its SH3 domain to the C-terminal proline-rich domain of PYK2. The encoded protein is tyrosine phosphorylated by activated PYK2. It has catalytic activity for class I and II ArfGAPs in vitro, and can bind the cl ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000281419
  • ENSP00000281419
  • ENSG00000151693
  • ENST00000315273
  • ENSP00000316404

Symbol
  • DDEF2
  • KIAA0400
  • PAP
  • PAG3
  • AMAP2
  • DDEF2
  • SHAG1
  • CENTB3
  • Pap-alpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
trait
0.86
transcription factor binding site profile
0.76
interacting protein
0.7
tissue sample
0.69


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.62   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 92   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.62   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 92   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (69)
SH3KBP1
Tbio
Family:  Enzyme
Novelty:  0.01454593
p_int:  0.999999992
p_ni:  8e-9
Score:  0.61
Data Source:  BioPlex,STRINGDB
NCK2
Tbio
Novelty:  0.02220251
p_int:  0.999999935
p_ni:  6.5e-8
Score:  0.271
Data Source:  BioPlex,STRINGDB
ARHGAP12
Tbio
Family:  Enzyme
Novelty:  0.12113722
p_int:  0.999999867
p_ni:  1.33e-7
Score:  0.156
Data Source:  BioPlex,STRINGDB
ASAP3
Tbio
Novelty:  0.06898579
p_int:  0.999999486
p_ni:  5.14e-7
Score:  0.84
Data Source:  BioPlex,STRINGDB
NCK1
Tbio
Novelty:  0.00352084
p_int:  0.99999861
p_ni:  0.000001364
p_wrong:  2.6e-8
Score:  0.263
Data Source:  BioPlex,STRINGDB
GRB2
Tchem
Novelty:  0.00091605
p_int:  0.999998527
p_ni:  0.000001439
p_wrong:  3.4e-8
Score:  0.344
Data Source:  BioPlex,STRINGDB
ARF6
Tbio
Family:  Enzyme
Novelty:  0.00278138
Score:  0.971
Data Source:  STRINGDB
ARF1
Tchem
Family:  Enzyme
Novelty:  0.00208554
Score:  0.968
Data Source:  STRINGDB
BIN1
Tbio
Novelty:  0.00312612
Score:  0.94
Data Source:  STRINGDB
COPA
Tbio
Novelty:  0.02712824
Score:  0.917
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
tumor necrosis factor receptor 1 measurement
1
1
1
56.2
birth weight
1
1
1
39.6
calcium measurement
1
1
1
12.4
1
1
0
1.1
6.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
tumor necrosis factor receptor 1 measurement
1
56.2
birth weight
1
39.6
calcium measurement
1
12.4
0
1.1
6.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
VGNC:173
459014
Macaque
ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
699774
Mouse
MGI:2685438
211914
Rat
RGD:1305263
362719
Dog
ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
VGNC:38154
475659
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
Macaque
ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
Mouse
Rat
Dog
ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
Publication Statistics
PubMed Score 36.62
PubMed score by year
PubTator Score 29.43
PubTator score by year
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Related Publications
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PMID
Year
Title