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Tbio
ASAP1
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1

Protein Summary
Description
Possesses phosphatidylinositol 4,5-bisphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types (By similarity). Plays a role in ciliogenesis. This gene encodes an ADP-ribosylation factor (ARF) GTPase-activating protein. The GTPase-activating activity is stimulated by phosphatidylinositol 4,5-biphosphate (PIP2), and is greater towards ARF1 and ARF5, and lesser for ARF6. This gene maybe involved in regulation of membrane trafficking and cytoskeleton remodeling. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000518721
  • ENSP00000429900
  • ENSG00000153317

Symbol
  • DDEF1
  • KIAA1249
  • PAP
  • PAG2
  • AMAP1
  • DDEF1
  • ZG14P
  • CENTB4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
transcription factor perturbation
0.91
transcription factor binding site profile
0.82
kinase perturbation
0.81
hub protein
0.79


Protein Classes
 No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 142.4   (req: < 5)
View Publications
Gene RIFs: 26   (req: <= 3)
View Gene RIFs
Antibodies: 221   (req: <= 50)
View Antibodies
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 142.4   (req: >= 5)
Gene RIFs: 26   (req: > 3)
Antibodies: 221   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
View GO Terms
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
 No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
View Data
Go To Tool
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
Go To Tool
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
Go To Tool
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Go To Tool
Approved Drugs (0)
 No approved drugs found
Active Ligands (0)
 No active ligands found
Protein-Protein Interactions (93)
1 – 10 of 93
SH3KBP1
Tbio
Family:  Enzyme
Novelty:  0.01454593
p_int:  0.999999981
p_ni:  1.6e-8
p_wrong:  3e-9
Score:  0.586
Data Source:  BioPlex,STRINGDB
GRB2
Tchem
Novelty:  0.00091605
p_int:  0.999999973
p_ni:  1e-8
p_wrong:  1.8e-8
Score:  0.493
Data Source:  BioPlex,STRINGDB
ARHGAP12
Tbio
Family:  Enzyme
Novelty:  0.12113722
p_int:  0.999999966
p_ni:  3.4e-8
Data Source:  BioPlex
ASAP3
Tbio
Novelty:  0.06898579
p_int:  0.999999656
p_ni:  3.44e-7
Score:  0.84
Data Source:  BioPlex,STRINGDB
NCK2
Tbio
Novelty:  0.02220251
p_int:  0.995068708
p_ni:  0.004864103
p_wrong:  0.000067189
Score:  0.274
Data Source:  BioPlex,STRINGDB
ARF4
Tbio
Family:  Enzyme
Novelty:  0.01166211
Score:  0.99
Data Source:  Reactome,STRINGDB
ARF1
Tchem
Family:  Enzyme
Novelty:  0.00208554
Score:  0.982
Data Source:  STRINGDB
RHO
Tbio
Family:  GPCR
Novelty:  0.00012925
Score:  0.975
Data Source:  Reactome,STRINGDB
RAB3IP
Tbio
Novelty:  0.04046982
Score:  0.975
Data Source:  Reactome,STRINGDB
RAB11A
Tbio
Family:  Enzyme
Novelty:  0.00153551
Score:  0.975
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
 Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
Cargo trafficking to the periciliary membrane (R-HSA-5620920)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cargo trafficking to the periciliary membrane
51 targets
R-HSA-5620920
Reactome
Cilium Assembly
187 targets
R-HSA-5617833
Reactome
Organelle biogenesis and maintenance
276 targets
R-HSA-1852241
Reactome
VxPx cargo-targeting to cilium
21 targets
R-HSA-5620916
Name
Explore in Pharos
Explore in Source
Cargo trafficking to the periciliary membrane
51 targets
R-HSA-5620920
Cilium Assembly
187 targets
R-HSA-5617833
Organelle biogenesis and maintenance
276 targets
R-HSA-1852241
VxPx cargo-targeting to cilium
21 targets
R-HSA-5620916
Viral Interactions (0)
 No viral interactions found
Gene Ontology Terms (15)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
cadherin binding
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
GTPase activator activity
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
metal ion binding
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
phosphatidylinositol-3,4,5-trisphosphate binding
Inferred from Electronic Annotation (IEA)
Ensembl
phosphatidylinositol-4,5-bisphosphate binding
Inferred from Electronic Annotation (IEA)
Ensembl
phosphatidylserine binding
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
 No disease associations found
GWAS Traits (18)
Items per page:
1 – 5 of 18
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
EFO_0004584
3
2
3
86.2
mean corpuscular volume
EFO_0004526
1
1
1
75.5
lymphocyte count
EFO_0004587
3
2
3
75.2
Tuberculosis
Orphanet_3389
1
1
0
1.2
73.9
platelet count
EFO_0004309
2
2
2
73.3
Items per page:
1 – 5 of 18
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
EFO_0004584
3
86.2
mean corpuscular volume
EFO_0004526
1
75.5
lymphocyte count
EFO_0004587
3
75.2
Tuberculosis
Orphanet_3389
0
1.2
73.9
platelet count
EFO_0004309
2
73.3
Find similar targets by:
IDG Resources
 No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
VGNC:2459
464399
Macaque
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
695681
Mouse
ArfGAP with SH3 domain, ankyrin repeat and PH domain1
MGI:1342335
13196
Rat
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
RGD:1307379
314961
Dog
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
VGNC:38153
482044
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
Macaque
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
Mouse
ArfGAP with SH3 domain, ankyrin repeat and PH domain1
Rat
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
Dog
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
Publication Statistics
PubMed Score 142.40
PubMed score by year
PubTator Score 52.07
PubTator score by year
Related Publications
Items per page:
0 of 0
PMID
Year
Title