Tbio ASAP1 Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1

Protein Summary

Description

Possesses phosphatidylinositol 4,5-bisphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types (By similarity). Plays a role in ciliogenesis. This gene encodes an ADP-ribosylation factor (ARF) GTPase-activating protein. The GTPase-activating activity is stimulated by phosphatidylinositol 4,5-biphosphate (PIP2), and is greater towards ARF1 and ARF5, and lesser for ARF6. This gene maybe involved in regulation of membrane trafficking and cytoskeleton remodeling. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Uniprot Accession IDs

• Q9ULH1
• B2RNV3

Gene Name

• ASAP1

Ensembl ID

• ENST00000518721
• ENSP00000429900
• ENSG00000153317

Symbol

• DDEF1
• KIAA1249
• PAP
• PAG2
• AMAP1
• DDEF1
• ZG14P
• CENTB4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.92
transcription factor perturbation	0.91
transcription factor binding site profile	0.82
kinase perturbation	0.81
hub protein	0.79

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 126.23   (req: < 5)

Gene RIFs: 26   (req: <= 3)

Antibodies: 221   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 126.23   (req: >= 5)

Gene RIFs: 26   (req: > 3)

Antibodies: 221   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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Target Illumination GWAS Analytics (TIGA)

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GENEVA

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GlyGen

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ARCHS4

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (93)

Explore Interacting Targets

1 – 10 of 93

• See Interactions on String-DB

SH3KBP1

Tbio

Family:  Enzyme

Novelty:  0.01454593

p_int:  0.999999981

p_ni:  1.6e-8

p_wrong:  3e-9

Score:  0.586

Data Source:  BioPlex,STRINGDB

GRB2

Tchem

Novelty:  0.00091605

p_int:  0.999999973

p_ni:  1e-8

p_wrong:  1.8e-8

Score:  0.493

Data Source:  BioPlex,STRINGDB

ARHGAP12

Tbio

Family:  Enzyme

Novelty:  0.12113722

p_int:  0.999999966

p_ni:  3.4e-8

Data Source:  BioPlex

ASAP3

Tbio

Novelty:  0.06898579

p_int:  0.999999656

p_ni:  3.44e-7

Score:  0.84

Data Source:  BioPlex,STRINGDB

NCK2

Tbio

Novelty:  0.02220251

p_int:  0.995068708

p_ni:  0.004864103

p_wrong:  0.000067189

Score:  0.274

Data Source:  BioPlex,STRINGDB

ARF4

Tbio

Family:  Enzyme

Novelty:  0.01166211

Score:  0.99

Data Source:  Reactome,STRINGDB

ARF1

Tchem

Family:  Enzyme

Novelty:  0.00208554

Score:  0.982

Data Source:  STRINGDB

RHO

Tbio

Family:  GPCR

Novelty:  0.00012925

Score:  0.975

Data Source:  Reactome,STRINGDB

RAB3IP

Tbio

Novelty:  0.04046982

Score:  0.975

Data Source:  Reactome,STRINGDB

RAB11A

Tbio

Family:  Enzyme

Novelty:  0.00153551

Score:  0.975

Data Source:  Reactome,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (11)

Reactome (4)

KEGG (2)

PathwayCommons (4)

WikiPathways (1)

Cargo trafficking to the periciliary membrane (R-HSA-5620920)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cargo trafficking to the periciliary membrane	51 targets	R-HSA-5620920
Reactome	Cilium Assembly	187 targets	R-HSA-5617833
Reactome	Organelle biogenesis and maintenance	276 targets	R-HSA-1852241
Reactome	VxPx cargo-targeting to cilium	21 targets	R-HSA-5620916

Name	Explore in Pharos	Explore in Source
Cargo trafficking to the periciliary membrane	51 targets	R-HSA-5620920
Cilium Assembly	187 targets	R-HSA-5617833
Organelle biogenesis and maintenance	276 targets	R-HSA-1852241
VxPx cargo-targeting to cilium	21 targets	R-HSA-5620916

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (15)

Functions (6)

Components (5)

Processes (4)

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10

1 – 6 of 6

GO Term	Evidence	Assigned by
cadherin binding	Inferred from High Throughput Direct Assay (HDA)	BHF-UCL
GTPase activator activity	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
phosphatidylinositol-3,4,5-trisphosphate binding	Inferred from Electronic Annotation (IEA)	Ensembl
phosphatidylinositol-4,5-bisphosphate binding	Inferred from Electronic Annotation (IEA)	Ensembl
phosphatidylserine binding	Inferred from Electronic Annotation (IEA)	Ensembl

Disease Associations ()

No disease associations found

GWAS Traits (14)

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1 – 5 of 14

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean platelet volume	EFO_0004584	3	2	3		94.8
mean corpuscular volume	EFO_0004526	1	1	1		85.3
lymphocyte count	EFO_0004587	2	2	2		84.7
platelet count	EFO_0004309	2	2	2		82.8
red blood cell distribution width	EFO_0005192	2	1	2		67.1

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 14

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean platelet volume	EFO_0004584	3		94.8
mean corpuscular volume	EFO_0004526	1		85.3
lymphocyte count	EFO_0004587	2		84.7
platelet count	EFO_0004309	2		82.8
red blood cell distribution width	EFO_0005192	2		67.1

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
ANK repeat
Cilium biogenesis/degradation
Complete proteome
Cytoplasm
GTPase activation
Membrane
Metal-binding
Phosphoprotein

GWAS Trait Find Similar Targets

No Header	No Header
balding measurement
bilirubin measurement
lymphocyte count
lymphocyte percentage of leukocytes
mean corpuscular volume
mean platelet volume
mean reticulocyte volume
platelet count
psychotic symptom measurement
red blood cell distribution width

IDG Resources

No IDG generated resources found

Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	VGNC:2459	464399
Macaque	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1		695681
Mouse	ArfGAP with SH3 domain, ankyrin repeat and PH domain1	MGI:1342335	13196
Rat	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	RGD:1307379	314961
Dog	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	VGNC:38153	482044

Species	Name	OMA	EggNOG	Inparanoid
Chimp	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
Macaque	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
Mouse	ArfGAP with SH3 domain, ankyrin repeat and PH domain1
Rat	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
Dog	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1

Publication Statistics

PubMed Score 126.23

PubMed score by year

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PubTator Score 52.07

PubTator score by year

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Related Publications

Text Mined References (46)

GeneRif Annotations (26)

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PMID	Year	Title