You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
ASAH1
Acid ceramidase

Protein Summary
Description
Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. This gene encodes a member of the acid ceramidase family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. Processing of this preproprotein generates alpha and beta subunits that heterodimerize to form the mature lysosomal enzyme, which catalyzes the degradation of ceramide into sphingosine and free fatty acid. This enzyme is overexpressed in multiple human cancers and may play a role in cancer progression. Mutations in this gene are associated with the lysosomal storage disorder, Farber lipogranulomatosis, and a neuromuscular disorder, spinal muscular atrophy with progressive myoclonic epilepsy. [provided by RefSeq, Oct 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262097
  • ENSP00000262097
  • ENSG00000104763
  • ENST00000314146
  • ENSP00000326970
  • ENST00000381733
  • ENSP00000371152
  • ENST00000635998
  • ENSP00000490506
  • ENST00000637790
  • ENSP00000490272

Symbol
  • ASAH
  • AC
  • PHP
  • ASAH
  • PHP32
  • ACDase
  • SMAPME
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
interacting protein
0.98
transcription factor perturbation
0.98
kinase perturbation
0.97
transcription factor binding site profile
0.88


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 308.56   (req: < 5)
Gene RIFs: 52   (req: <= 3)
Antibodies: 271   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 308.56   (req: >= 5)
Gene RIFs: 52   (req: > 3)
Antibodies: 271   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 135
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1