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Tbio
ARVCF
Armadillo repeat protein deleted in velo-cardio-facial syndrome

Protein Summary
Description
Involved in protein-protein interactions at adherens junctions. Armadillo Repeat gene deleted in Velo-Cardio-Facial syndrome (ARVCF) is a member of the catenin family. This family plays an important role in the formation of adherens junction complexes, which are thought to facilitate communication between the inside and outside environments of a cell. The ARVCF gene was isolated in the search for the genetic defect responsible for the autosomal dominant Velo-Cardio-Facial syndrome (VCFS), a relatively common human disorder with phenotypic features including cleft palate, conotruncal heart defects and facial dysmorphology. The ARVCF gene encodes a protein containing two motifs, a coiled coil domain in the N-terminus and a 10 armadillo repeat sequence in the midregion. Since these sequences can facilitate protein-protein interactions ARVCF is thought to function in a protein complex. In addition, ARVCF contains a predicted nuclear-targeting sequence suggesting that it may have a function ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263207
  • ENSP00000263207
  • ENSG00000099889
  • ENST00000401994
  • ENSP00000384341
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.78
kinase perturbation
0.76
trait
0.75
protein domain
0.73
cell line
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.12   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 84   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.12   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 84   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (74)
CDH8
Tbio
Novelty:  0.04055999
p_int:  0.999999953
p_ni:  4.3e-8
p_wrong:  4e-9
Score:  0.313
Data Source:  BioPlex,STRINGDB
CDH5
Tbio
Novelty:  0.00072649
p_int:  0.9999996
p_ni:  3.99e-7
p_wrong:  1e-9
Score:  0.413
Data Source:  BioPlex,STRINGDB
CTNNA3
Tbio
Novelty:  0.01472452
p_int:  0.999989529
p_ni:  0.000010471
Score:  0.375
Data Source:  BioPlex,STRINGDB
TAX1BP3
Tbio
Novelty:  0.01605171
p_int:  0.99790811
p_ni:  0.002091834
p_wrong:  5.6e-8
Data Source:  BioPlex
TACR1
Tclin
Family:  GPCR
Novelty:  0.00062762
p_int:  0.992216637
p_ni:  0.007783349
p_wrong:  1.5e-8
Data Source:  BioPlex
SDC1
Tbio
Novelty:  0.00044792
p_int:  0.990765404
p_ni:  0.009234593
p_wrong:  2e-9
Data Source:  BioPlex
CYP2S1
Tbio
Novelty:  0.02967417
p_int:  0.985779966
p_ni:  0.014220033
Data Source:  BioPlex
GJB7
Tbio
Novelty:  0.12555147
p_int:  0.955816294
p_ni:  0.044116638
p_wrong:  0.000067068
Score:  0.183
Data Source:  BioPlex,STRINGDB
SEMA4C
Tbio
Novelty:  0.01237067
p_int:  0.94667785
p_ni:  0.052847842
p_wrong:  0.000474308
Data Source:  BioPlex
S1PR2
Tchem
Family:  GPCR
Novelty:  0.00372765
p_int:  0.846826464
p_ni:  0.117491398
p_wrong:  0.035682138
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (26)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum metabolite measurement
1
2
3
92.8
lymphocyte count
3
3
3
90.4
platelet count
3
3
2
2.1
89.5
platelet crit
2
2
2
88.7
blood metabolite measurement
1
1
2
88
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum metabolite measurement
3
92.8
lymphocyte count
3
90.4
platelet count
2
2.1
89.5
platelet crit
2
88.7
blood metabolite measurement
2
88
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ARVCF, delta catenin family member
VGNC:6688
458656
Macaque
ARVCF, delta catenin family member
712399
Mouse
MGI:109620
11877
Rat
RGD:1306655
303798
Dog
ARVCF, delta catenin family member
VGNC:49589
486417
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ARVCF, delta catenin family member
Macaque
ARVCF, delta catenin family member
Mouse
Rat
Dog
ARVCF, delta catenin family member
Publication Statistics
PubMed Score 32.12
PubMed score by year
PubTator Score 24.13
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title