Protein Summary
Plays a role as a mediator in the endoplasmic reticulum (ER) cholesterol and bile acid homeostasis (PubMed:11063737, PubMed:12145310, PubMed:20663892). Participates in sterol transport out of the ER and distribution into plasma membranes (PubMed:20663892). this gene encodes a transmembrane protein that contains a conserved zinc ribbon motif at the N- terminus. A similar protein in mouse is thought to function in fatty acid homeostasis. Mutations in this gene are associated with early infantile epileptic encephalopathy 38. [provided by RefSeq, Nov 2016]
- ENST00000310256
- ENSP00000312458
- ENSG00000173409
- EIEE38
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor binding site profile | 0.9 | ||
histone modification site profile | 0.8 | ||
kinase perturbation | 0.66 | ||
tissue sample | 0.62 | ||
transcription factor | 0.59 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 34.77 (req: < 5)
Gene RIFs: 6 (req: <= 3)
Antibodies: 88 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 34.77 (req: >= 5)
Gene RIFs: 6 (req: > 3)
Antibodies: 88 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (56)
C3AR1
Family: GPCR
Novelty: 0.00527301
p_int: 0.993252515
p_ni: 0.006746901
p_wrong: 5.84e-7
Data Source: BioPlex
P2RX5
Family: IC
Novelty: 0.01591178
p_int: 0.989083811
p_ni: 0.010916171
p_wrong: 1.9e-8
Data Source: BioPlex
TSPAN31
Novelty: 0.13580467
p_int: 0.98601356
p_ni: 0.013986365
p_wrong: 7.5e-8
Data Source: BioPlex
MFAP5
Novelty: 0.01839035
p_int: 0.983965348
p_ni: 0.01577865
p_wrong: 0.000256002
Data Source: BioPlex
TGFA
Novelty: 0.00216159
p_int: 0.935616815
p_ni: 0.064338274
p_wrong: 0.000044911
Data Source: BioPlex
CLEC2D
Novelty: 0.02501194
p_int: 0.910359795
p_ni: 0.089607865
p_wrong: 0.00003234
Data Source: BioPlex
CD4
Novelty: 0.00001217
p_int: 0.900144953
p_ni: 0.099765879
p_wrong: 0.000089168
Score: 0.185
Data Source: BioPlex,STRINGDB
IL13RA2
Novelty: 0.03465642
p_int: 0.889694506
p_ni: 0.110277353
p_wrong: 0.00002814
Data Source: BioPlex
SLC22A2
Family: Transporter
Novelty: 0.00439263
p_int: 0.886988293
p_ni: 0.109969392
p_wrong: 0.003042315
Data Source: BioPlex
Nearest Tclin Targets
Pathways (4)
Reactome (4)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cholesterol biosynthesis | ||||
Reactome | Metabolism | ||||
Reactome | Metabolism of lipids | ||||
Reactome | Metabolism of steroids | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cholesterol biosynthesis | ||||
Metabolism | ||||
Metabolism of lipids | ||||
Metabolism of steroids | ||||
Viral Interactions (0)
Gene Ontology Terms (14)
Functions (1)
Components (4)
Processes (9)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | Reactome | |||
Disease Associations ()
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
hematocrit | 1 | 1 | 1 | 60.2 | |||||
mean platelet volume | 1 | 1 | 1 | 51.4 | |||||
hemoglobin measurement | 1 | 1 | 1 | 44.2 | |||||
soluble triggering receptor expressed on myeloid cells 2 measurement | 1 | 1 | 0 | 8832.8 | 0.7 | ||||
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
hematocrit | 1 | 60.2 | |||||
mean platelet volume | 1 | 51.4 | |||||
hemoglobin measurement | 1 | 44.2 | |||||
soluble triggering receptor expressed on myeloid cells 2 measurement | 0 | 8832.8 | 0.7 | ||||
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | ARV1 homolog, fatty acid homeostasis modulator | VGNC:7347 | 457815 | |||||
Macaque | ARV1 homolog, fatty acid homeostasis modulator | 713975 | ||||||
Mouse | MGI:1916115 | 68865 | ||||||
Rat | RGD:1310264 | 292097 | ||||||
Dog | ARV1 homolog, fatty acid homeostasis modulator | VGNC:38150 | 488975 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | ARV1 homolog, fatty acid homeostasis modulator | |||||
Macaque | ARV1 homolog, fatty acid homeostasis modulator | |||||
Mouse | ||||||
Rat | ||||||
Dog | ARV1 homolog, fatty acid homeostasis modulator | |||||
Publication Statistics
PubMed Score 34.77
PubMed score by year
PubTator Score 9.60
PubTator score by year
Related Publications
Text Mined References (13)
GeneRif Annotations (6)
Items per page:
0 of 0
PMID | Year | Title |
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