You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
ARV1
Protein ARV1

Protein Summary
Description
Plays a role as a mediator in the endoplasmic reticulum (ER) cholesterol and bile acid homeostasis (PubMed:11063737, PubMed:12145310, PubMed:20663892). Participates in sterol transport out of the ER and distribution into plasma membranes (PubMed:20663892). this gene encodes a transmembrane protein that contains a conserved zinc ribbon motif at the N- terminus. A similar protein in mouse is thought to function in fatty acid homeostasis. Mutations in this gene are associated with early infantile epileptic encephalopathy 38. [provided by RefSeq, Nov 2016]
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.9
histone modification site profile
0.8
kinase perturbation
0.66
tissue sample
0.62
transcription factor
0.59


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.77   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 88   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.77   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 88   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (56)
C3AR1
Tchem
Family:  GPCR
Novelty:  0.00527301
p_int:  0.993252515
p_ni:  0.006746901
p_wrong:  5.84e-7
Data Source:  BioPlex
P2RX5
Tchem
Family:  IC
Novelty:  0.01591178
p_int:  0.989083811
p_ni:  0.010916171
p_wrong:  1.9e-8
Data Source:  BioPlex
TSPAN31
Tbio
Novelty:  0.13580467
p_int:  0.98601356
p_ni:  0.013986365
p_wrong:  7.5e-8
Data Source:  BioPlex
MFAP5
Tbio
Novelty:  0.01839035
p_int:  0.983965348
p_ni:  0.01577865
p_wrong:  0.000256002
Data Source:  BioPlex
PVR
Tbio
Novelty:  0.00215811
p_int:  0.939193049
p_ni:  0.06080695
p_wrong:  1e-9
Data Source:  BioPlex
TGFA
Tbio
Novelty:  0.00216159
p_int:  0.935616815
p_ni:  0.064338274
p_wrong:  0.000044911
Data Source:  BioPlex
CLEC2D
Tbio
Novelty:  0.02501194
p_int:  0.910359795
p_ni:  0.089607865
p_wrong:  0.00003234
Data Source:  BioPlex
CD4
Tclin
Novelty:  0.00001217
p_int:  0.900144953
p_ni:  0.099765879
p_wrong:  0.000089168
Score:  0.185
Data Source:  BioPlex,STRINGDB
IL13RA2
Tbio
Novelty:  0.03465642
p_int:  0.889694506
p_ni:  0.110277353
p_wrong:  0.00002814
Data Source:  BioPlex
SLC22A2
Tchem
Family:  Transporter
Novelty:  0.00439263
p_int:  0.886988293
p_ni:  0.109969392
p_wrong:  0.003042315
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Cholesterol biosynthesis (R-HSA-191273)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cholesterol biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Metabolism of steroids
Name
Explore in Pharos
Explore in Source
Cholesterol biosynthesis
Metabolism
Metabolism of lipids
Metabolism of steroids
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
1
1
1
60.2
mean platelet volume
1
1
1
51.4
hemoglobin measurement
1
1
1
44.2
soluble triggering receptor expressed on myeloid cells 2 measurement
1
1
0
8832.8
0.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
1
60.2
mean platelet volume
1
51.4
hemoglobin measurement
1
44.2
soluble triggering receptor expressed on myeloid cells 2 measurement
0
8832.8
0.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ARV1 homolog, fatty acid homeostasis modulator
VGNC:7347
457815
Macaque
ARV1 homolog, fatty acid homeostasis modulator
713975
Mouse
MGI:1916115
68865
Rat
RGD:1310264
292097
Dog
ARV1 homolog, fatty acid homeostasis modulator
VGNC:38150
488975
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ARV1 homolog, fatty acid homeostasis modulator
Macaque
ARV1 homolog, fatty acid homeostasis modulator
Mouse
Rat
Dog
ARV1 homolog, fatty acid homeostasis modulator
Publication Statistics
PubMed Score 34.77
PubMed score by year
PubTator Score 9.60
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title