Tbio ARTN Artemin

Protein Summary

Description

Ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor complex. Supports the survival of sensory and sympathetic peripheral neurons in culture and also supports the survival of dopaminergic neurons of the ventral mid-brain. Strong attractant of gut hematopoietic cells thus promoting the formation Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue. This gene encodes a secreted ligand of the glial cell line-derived neurotrophic factor (GDNF) subfamily and TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein signals through the RET receptor and GFR alpha 3 coreceptor, and supports the survival of a number of peripheral neuron populations and at least one population of dopaminergic CNS neurons. This protein has also been shown to promote tumor growth, metastasis, and drug resistance in mammary carcinoma. [provided by RefSeq, Aug 2016]

Uniprot Accession IDs

• Q5T4W7
• D3DPY1
• D3DPY3
• O95441
• O96030
• Q6P6A3

Gene Name

• ARTN

Ensembl ID

• ENST00000372354
• ENSP00000361429
• ENSG00000117407
• ENST00000372359
• ENSP00000361434
• ENST00000414809
• ENSP00000387435
• ENST00000438616
• ENSP00000391998
• ENST00000498139
• ENSP00000436727

Symbol

• EVN
• ART
• EVN
• NBN
• ENOVIN

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.71
small molecule perturbation	0.69
gene perturbation	0.67
transcription factor	0.63
transcription factor binding site profile	0.63

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Growth Factor / Neurotrophic Factor / Artemin

DTO Classes

Protein / Signaling / Growth Factor / Neurotrophic Factor / Artemin

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 194.24   (req: < 5)

Gene RIFs: 35   (req: <= 3)

Antibodies: 320   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 194.24   (req: >= 5)

Gene RIFs: 35   (req: > 3)

Antibodies: 320   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0