Tbio ARSK Arylsulfatase K

Protein Summary

Description

Sulfatases (EC 3.1.5.6), such as ARSK, hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans, and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of macromolecules (Sardiello et al., 2005 [PubMed 16174644]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q6UWY0
• A2BDE3
• B4E1I4
• Q3ZCW3
• Q8N3Q8
• ASK

Gene Name

• ARSK

Ensembl ID

• ENST00000380009
• ENSP00000369346
• ENSG00000164291

Symbol

• TSULF
• TSULF

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.88
kinase perturbation	0.76
transcription factor binding site profile	0.7
cell type or tissue	0.57
gene perturbation	0.56

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.02   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 98   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.02   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 98   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (75)

Explore Interacting Targets

1 – 10 of 75

• See Interactions on String-DB

ATG2B

Tbio

Novelty:  0.04963717

p_int:  0.996886902

p_ni:  0.003112742

p_wrong:  3.57e-7

Data Source:  BioPlex

LACRT

Tbio

Novelty:  0.03333799

p_int:  0.995746565

p_ni:  0.004253435

Score:  0.257

Data Source:  BioPlex,STRINGDB

SCGB2A2

Tbio

Novelty:  0.01594053

p_int:  0.995657275

p_ni:  0.004342725

Data Source:  BioPlex

ZNF621

Tdark

Family:  TF

Novelty:  1.96460285

p_int:  0.995555696

p_ni:  7e-9

p_wrong:  0.004444296

Data Source:  BioPlex

TAZ

Tbio

Novelty:  0.00372301

p_int:  0.992094068

p_ni:  0.007905917

p_wrong:  1.5e-8

Data Source:  BioPlex

SCGB1D1

Tbio

Novelty:  0.04199997

p_int:  0.991756925

p_ni:  0.008243074

p_wrong:  1e-9

Data Source:  BioPlex

INSL5

Tbio

Novelty:  0.04351334

p_int:  0.991154573

p_ni:  0.008845416

p_wrong:  1.1e-8

Data Source:  BioPlex

NAAA

Tchem

Family:  Enzyme

Novelty:  0.00368876

p_int:  0.990752457

p_ni:  0.00924754

p_wrong:  3e-9

Data Source:  BioPlex

CST9L

Tdark

Novelty:  0.21941207

p_int:  0.989399466

p_ni:  0.010600534

Data Source:  BioPlex

ISLR

Tbio

Novelty:  0.02936208

p_int:  0.98866581

p_ni:  0.011334092

p_wrong:  9.8e-8

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (8)

Reactome (8)

Gamma carboxylation, hypusine formation and arylsulfatase activation (R-HSA-163841)

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1 – 5 of 8

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Gamma carboxylation, hypusine formation and arylsulfatase activation	39 targets	R-HSA-163841
Reactome	Glycosphingolipid metabolism	46 targets	R-HSA-1660662
Reactome	Metabolism	2112 targets	R-HSA-1430728
Reactome	Metabolism of lipids	740 targets	R-HSA-556833
Reactome	Metabolism of proteins	2050 targets	R-HSA-392499

Name	Explore in Pharos	Explore in Source
Gamma carboxylation, hypusine formation and arylsulfatase activation	39 targets	R-HSA-163841
Glycosphingolipid metabolism	46 targets	R-HSA-1660662
Metabolism	2112 targets	R-HSA-1430728
Metabolism of lipids	740 targets	R-HSA-556833
Metabolism of proteins	2050 targets	R-HSA-392499

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (4)

Functions (2)

Components (2)

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Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
arylsulfatase activity	Traceable Author Statement (TAS)	HGNC
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations (null)

No disease associations found

GWAS Traits (3)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 3 of 3

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
FEV/FEC ratio	EFO_0004713	1	1	1		79.9
chronic obstructive pulmonary disease	EFO_0000341	1	1	0	1.1	8.6
pulmonary function measurement	EFO_0003892	1	1	1		3.8

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 3 of 3

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
FEV/FEC ratio	EFO_0004713	1		79.9
chronic obstructive pulmonary disease	EFO_0000341	0	1.1	8.6
pulmonary function measurement	EFO_0003892	1		3.8

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UniProt Keyword Find Similar Targets

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Calcium
Complete proteome
Glycoprotein
Hydrolase
Metal-binding
Polymorphism
Reference proteome
Secreted
Signal

GWAS Trait Find Similar Targets

No Header	No Header
chronic obstructive pulmonary disease
FEV/FEC ratio
pulmonary function measurement

IDG Resources

No IDG generated resources found

Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	arylsulfatase family member K	VGNC:11830	461745
Mouse	arylsulfatase K	MGI:1924291	77041
Rat	arylsulfatase family, member K	RGD:1310182	365619
Dog	arylsulfatase family member K	VGNC:38146	488903
Horse	arylsulfatase family member K	VGNC:15551	100073230

Species	Name	OMA	EggNOG	Inparanoid
Chimp	arylsulfatase family member K
Mouse	arylsulfatase K
Rat	arylsulfatase family, member K
Dog	arylsulfatase family member K
Horse	arylsulfatase family member K

Publication Statistics

PubMed Score 11.02

PubMed score by year

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PubTator Score 183.18

PubTator score by year

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Related Publications

Text Mined References (6)

GeneRif Annotations (2)

Items per page:

10

0 of 0

PMID	Year	Title