Protein Summary
Sulfatases (EC 3.1.5.6), such as ARSK, hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans, and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of macromolecules (Sardiello et al., 2005 [PubMed 16174644]).[supplied by OMIM, Mar 2008]
- ENST00000380009
- ENSP00000369346
- ENSG00000164291
- TSULF
- TSULF
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
histone modification site profile | 0.88 | ||
kinase perturbation | 0.76 | ||
transcription factor binding site profile | 0.7 | ||
cell type or tissue | 0.57 | ||
gene perturbation | 0.56 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 11.02 (req: < 5)
Gene RIFs: 2 (req: <= 3)
Antibodies: 98 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 11.02 (req: >= 5)
Gene RIFs: 2 (req: > 3)
Antibodies: 98 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 2
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (75)
ATG2B
Novelty: 0.04963717
p_int: 0.996886902
p_ni: 0.003112742
p_wrong: 3.57e-7
Data Source: BioPlex
LACRT
Novelty: 0.03333799
p_int: 0.995746565
p_ni: 0.004253435
Score: 0.257
Data Source: BioPlex,STRINGDB
ZNF621
Family: TF
Novelty: 1.96460285
p_int: 0.995555696
p_ni: 7e-9
p_wrong: 0.004444296
Data Source: BioPlex
TAZ
Novelty: 0.00372301
p_int: 0.992094068
p_ni: 0.007905917
p_wrong: 1.5e-8
Data Source: BioPlex
SCGB1D1
Novelty: 0.04199997
p_int: 0.991756925
p_ni: 0.008243074
p_wrong: 1e-9
Data Source: BioPlex
INSL5
Novelty: 0.04351334
p_int: 0.991154573
p_ni: 0.008845416
p_wrong: 1.1e-8
Data Source: BioPlex
NAAA
Family: Enzyme
Novelty: 0.00368876
p_int: 0.990752457
p_ni: 0.00924754
p_wrong: 3e-9
Data Source: BioPlex
ISLR
Novelty: 0.02936208
p_int: 0.98866581
p_ni: 0.011334092
p_wrong: 9.8e-8
Data Source: BioPlex
Nearest Tclin Targets
Pathways (8)
Reactome (8)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Gamma carboxylation, hypusine formation and arylsulfatase activation | ||||
Reactome | Glycosphingolipid metabolism | ||||
Reactome | Metabolism | ||||
Reactome | Metabolism of lipids | ||||
Reactome | Metabolism of proteins | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Gamma carboxylation, hypusine formation and arylsulfatase activation | ||||
Glycosphingolipid metabolism | ||||
Metabolism | ||||
Metabolism of lipids | ||||
Metabolism of proteins | ||||
Viral Interactions (0)
Gene Ontology Terms (4)
Functions (2)
Components (2)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Traceable Author Statement (TAS) | HGNC | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
FEV/FEC ratio | 1 | 1 | 1 | 79.9 | |||||
1 | 1 | 0 | 1.1 | 8.6 | |||||
pulmonary function measurement | 1 | 1 | 1 | 3.8 | |||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
FEV/FEC ratio | 1 | 79.9 | |||||
0 | 1.1 | 8.6 | |||||
pulmonary function measurement | 1 | 3.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | arylsulfatase family member K | VGNC:11830 | 461745 | |||||
Mouse | MGI:1924291 | 77041 | ||||||
Rat | RGD:1310182 | 365619 | ||||||
Dog | arylsulfatase family member K | VGNC:38146 | 488903 | |||||
Horse | arylsulfatase family member K | VGNC:15551 | 100073230 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | arylsulfatase family member K | |||||
Mouse | ||||||
Rat | ||||||
Dog | arylsulfatase family member K | |||||
Horse | arylsulfatase family member K | |||||
Publication Statistics
PubMed Score 11.02
PubMed score by year
PubTator Score 183.18
PubTator score by year
Related Publications
Text Mined References (6)
GeneRif Annotations (2)
Items per page:
0 of 0
PMID | Year | Title |
---|