Tbio ARSI Arylsulfatase I

Protein Summary

Description

Displays arylsulfatase activity at neutral pH, when co-expressed with SUMF1; arylsulfatase activity is measured in the secretion medium of retinal cell line, but no activity is recorded when measured in cell extracts. This gene encodes a protein that belongs to a large family of sulfatases that hydrolyze sulfate esters and sulfamates. Members of this family play a role in several cellular processes, including hormone synthesis, cell signaling in development and degradation of macromolecules. The protein encoded by this gene is thought to be secreted, and to function in extracellular space. [provided by RefSeq, Jul 2016]

Uniprot Accession IDs

• Q5FYB1
• A1L3B0
• B3KV22
• B7XD03
• ASI

Gene Name

• ARSI

Ensembl ID

• ENST00000328668
• ENSP00000333395
• ENSG00000183876
• ENST00000515301
• ENSP00000426879

Symbol

• ASI
• SPG66

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.59
protein domain	0.58
PubMedID	0.58
histone modification site profile	0.49
disease	0.46

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.36   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 167   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.36   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 167   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (36)

Explore Interacting Targets

1 – 10 of 36

• See Interactions on String-DB

NOL11

Tbio

Novelty:  0.47253767

p_int:  0.967184222

p_ni:  0.032815694

p_wrong:  8.4e-8

Score:  0.309

Data Source:  BioPlex,STRINGDB

AHCYL2

Tbio

Family:  Enzyme

Novelty:  0.08695339

p_int:  0.866866847

p_ni:  0.133133152

p_wrong:  2e-9

Score:  0.223

Data Source:  BioPlex,STRINGDB

HSPA5

Tchem

Novelty:  0.00043424

p_int:  0.837239914

p_ni:  0.162760086

Score:  0.153

Data Source:  BioPlex,STRINGDB

SUMF1

Tbio

Family:  Enzyme

Novelty:  0.00954537

Score:  0.974

Data Source:  STRINGDB

SUMF2

Tbio

Family:  Enzyme

Novelty:  0.07551737

Score:  0.952

Data Source:  STRINGDB

ARSK

Tbio

Family:  Enzyme

Novelty:  0.11486213

Score:  0.948

Data Source:  STRINGDB

ARSH

Tbio

Family:  Enzyme

Novelty:  0.03202479

Score:  0.941

Data Source:  STRINGDB

STS

Tchem

Family:  Enzyme

Novelty:  0.00324549

Score:  0.925

Data Source:  STRINGDB

ARSE

Tbio

Family:  Enzyme

Novelty:  0.00151862

Score:  0.922

Data Source:  STRINGDB

ARSG

Tbio

Family:  Enzyme

Novelty:  0.04412917

Score:  0.921

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (8)

Reactome (8)

Gamma carboxylation, hypusine formation and arylsulfatase activation (R-HSA-163841)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Gamma carboxylation, hypusine formation and arylsulfatase activation	39 targets	R-HSA-163841
Reactome	Glycosphingolipid metabolism	46 targets	R-HSA-1660662
Reactome	Metabolism	2112 targets	R-HSA-1430728
Reactome	Metabolism of lipids	740 targets	R-HSA-556833
Reactome	Metabolism of proteins	2050 targets	R-HSA-392499

Name	Explore in Pharos	Explore in Source
Gamma carboxylation, hypusine formation and arylsulfatase activation	39 targets	R-HSA-163841
Glycosphingolipid metabolism	46 targets	R-HSA-1660662
Metabolism	2112 targets	R-HSA-1430728
Metabolism of lipids	740 targets	R-HSA-556833
Metabolism of proteins	2050 targets	R-HSA-392499

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (4)

Functions (2)

Components (2)

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10

1 – 2 of 2

GO Term	Evidence	Assigned by
arylsulfatase activity	Traceable Author Statement (TAS)	HGNC
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations (null)

No disease associations found

GWAS Traits (3)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mitochondrial heteroplasmy measurement	EFO_0600008	1	1	1		24.5
ulcerative colitis	EFO_0000729	1	1	0	1.1	21.5
gut microbiome measurement	EFO_0007874	1	1	0	3.3	21.5

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 3 of 3

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mitochondrial heteroplasmy measurement	EFO_0600008	1		24.5
ulcerative colitis	EFO_0000729	0	1.1	21.5
gut microbiome measurement	EFO_0007874	0	3.3	21.5

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UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Calcium
Complete proteome
Endoplasmic reticulum
Glycoprotein
Hydrolase
Metal-binding
Oxidation
Reference proteome
Secreted

GWAS Trait Find Similar Targets

No Header	No Header
gut microbiome measurement
mitochondrial heteroplasmy measurement
ulcerative colitis

IDG Resources

No IDG generated resources found

Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	arylsulfatase family member I	VGNC:11824	471695
Macaque	arylsulfatase family member I		712077
Mouse	arylsulfatase i	MGI:2670959	545260
Rat	arylsulfatase family, member I	RGD:1310242	307404
Dog	arylsulfatase family member I	VGNC:38144	489186

Species	Name	OMA	EggNOG	Inparanoid
Chimp	arylsulfatase family member I
Macaque	arylsulfatase family member I
Mouse	arylsulfatase i
Rat	arylsulfatase family, member I
Dog	arylsulfatase family member I

Publication Statistics

PubMed Score 28.36

PubMed score by year

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PubTator Score 95.72

PubTator score by year

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Related Publications

Text Mined References (10)

GeneRif Annotations (2)

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PMID	Year	Title