Protein Summary
Displays arylsulfatase activity at neutral pH, when co-expressed with SUMF1; arylsulfatase activity is measured in the secretion medium of retinal cell line, but no activity is recorded when measured in cell extracts. This gene encodes a protein that belongs to a large family of sulfatases that hydrolyze sulfate esters and sulfamates. Members of this family play a role in several cellular processes, including hormone synthesis, cell signaling in development and degradation of macromolecules. The protein encoded by this gene is thought to be secreted, and to function in extracellular space. [provided by RefSeq, Jul 2016]
- ENST00000328668
- ENSP00000333395
- ENSG00000183876
- ENST00000515301
- ENSP00000426879
- ASI
- SPG66
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
gene perturbation | 0.59 | ||
protein domain | 0.58 | ||
PubMedID | 0.58 | ||
histone modification site profile | 0.49 | ||
disease | 0.46 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 28.36 (req: < 5)
Gene RIFs: 2 (req: <= 3)
Antibodies: 167 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 28.36 (req: >= 5)
Gene RIFs: 2 (req: > 3)
Antibodies: 167 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 2
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (36)
NOL11
Novelty: 0.47253767
p_int: 0.967184222
p_ni: 0.032815694
p_wrong: 8.4e-8
Score: 0.309
Data Source: BioPlex,STRINGDB
AHCYL2
Family: Enzyme
Novelty: 0.08695339
p_int: 0.866866847
p_ni: 0.133133152
p_wrong: 2e-9
Score: 0.223
Data Source: BioPlex,STRINGDB
HSPA5
Novelty: 0.00043424
p_int: 0.837239914
p_ni: 0.162760086
Score: 0.153
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (8)
Reactome (8)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Gamma carboxylation, hypusine formation and arylsulfatase activation | ||||
Reactome | Glycosphingolipid metabolism | ||||
Reactome | Metabolism | ||||
Reactome | Metabolism of lipids | ||||
Reactome | Metabolism of proteins | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Gamma carboxylation, hypusine formation and arylsulfatase activation | ||||
Glycosphingolipid metabolism | ||||
Metabolism | ||||
Metabolism of lipids | ||||
Metabolism of proteins | ||||
Viral Interactions (0)
Gene Ontology Terms (4)
Functions (2)
Components (2)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Traceable Author Statement (TAS) | HGNC | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
mitochondrial heteroplasmy measurement | 1 | 1 | 1 | 24.5 | |||||
1 | 1 | 0 | 1.1 | 21.5 | |||||
gut microbiome measurement | 1 | 1 | 0 | 3.3 | 21.5 | ||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
mitochondrial heteroplasmy measurement | 1 | 24.5 | |||||
0 | 1.1 | 21.5 | |||||
gut microbiome measurement | 0 | 3.3 | 21.5 | ||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | arylsulfatase family member I | VGNC:11824 | 471695 | |||||
Macaque | arylsulfatase family member I | 712077 | ||||||
Mouse | MGI:2670959 | 545260 | ||||||
Rat | RGD:1310242 | 307404 | ||||||
Dog | arylsulfatase family member I | VGNC:38144 | 489186 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | arylsulfatase family member I | |||||
Macaque | arylsulfatase family member I | |||||
Mouse | ||||||
Rat | ||||||
Dog | arylsulfatase family member I | |||||
Publication Statistics
PubMed Score 28.36
PubMed score by year
PubTator Score 95.72
PubTator score by year
Related Publications
Text Mined References (10)
GeneRif Annotations (2)
Items per page:
0 of 0
PMID | Year | Title |
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