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Tbio
ARSI
Arylsulfatase I

Protein Summary
Description
Displays arylsulfatase activity at neutral pH, when co-expressed with SUMF1; arylsulfatase activity is measured in the secretion medium of retinal cell line, but no activity is recorded when measured in cell extracts. This gene encodes a protein that belongs to a large family of sulfatases that hydrolyze sulfate esters and sulfamates. Members of this family play a role in several cellular processes, including hormone synthesis, cell signaling in development and degradation of macromolecules. The protein encoded by this gene is thought to be secreted, and to function in extracellular space. [provided by RefSeq, Jul 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000328668
  • ENSP00000333395
  • ENSG00000183876
  • ENST00000515301
  • ENSP00000426879

Symbol
  • ASI
  • SPG66
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.59
protein domain
0.58
PubMedID
0.58
histone modification site profile
0.49
disease
0.46


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.36   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 167   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.36   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 167   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (36)
NOL11
Tbio
Novelty:  0.47253767
p_int:  0.967184222
p_ni:  0.032815694
p_wrong:  8.4e-8
Score:  0.309
Data Source:  BioPlex,STRINGDB
AHCYL2
Tbio
Family:  Enzyme
Novelty:  0.08695339
p_int:  0.866866847
p_ni:  0.133133152
p_wrong:  2e-9
Score:  0.223
Data Source:  BioPlex,STRINGDB
HSPA5
Tchem
Novelty:  0.00043424
p_int:  0.837239914
p_ni:  0.162760086
Score:  0.153
Data Source:  BioPlex,STRINGDB
SUMF1
Tbio
Family:  Enzyme
Novelty:  0.00954537
Score:  0.974
Data Source:  STRINGDB
SUMF2
Tbio
Family:  Enzyme
Novelty:  0.07551737
Score:  0.952
Data Source:  STRINGDB
ARSK
Tbio
Family:  Enzyme
Novelty:  0.11486213
Score:  0.948
Data Source:  STRINGDB
ARSH
Tbio
Family:  Enzyme
Novelty:  0.03202479
Score:  0.941
Data Source:  STRINGDB
STS
Tchem
Family:  Enzyme
Novelty:  0.00324549
Score:  0.925
Data Source:  STRINGDB
ARSE
Tbio
Family:  Enzyme
Novelty:  0.00151862
Score:  0.922
Data Source:  STRINGDB
ARSG
Tbio
Family:  Enzyme
Novelty:  0.04412917
Score:  0.921
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Gamma carboxylation, hypusine formation and arylsulfatase activation (R-HSA-163841)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gamma carboxylation, hypusine formation and arylsulfatase activation
Reactome
Glycosphingolipid metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Gamma carboxylation, hypusine formation and arylsulfatase activation
Glycosphingolipid metabolism
Metabolism
Metabolism of lipids
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mitochondrial heteroplasmy measurement
1
1
1
24.5
1
1
0
1.1
21.5
gut microbiome measurement
1
1
0
3.3
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mitochondrial heteroplasmy measurement
1
24.5
0
1.1
21.5
gut microbiome measurement
0
3.3
21.5
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
arylsulfatase family member I
VGNC:11824
471695
Macaque
arylsulfatase family member I
712077
Mouse
MGI:2670959
545260
Rat
RGD:1310242
307404
Dog
arylsulfatase family member I
VGNC:38144
489186
Species
Name
OMA
EggNOG
Inparanoid
Chimp
arylsulfatase family member I
Macaque
arylsulfatase family member I
Mouse
Rat
Dog
arylsulfatase family member I
Publication Statistics
PubMed Score 28.36
PubMed score by year
PubTator Score 95.72
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title