Tbio ARSH Arylsulfatase H

Protein Summary

Description

Sulfatases, such as ARSH, hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans, and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of macromolecules (Sardiello et al., 2005 [PubMed 16174644]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q5FYA8
• ASH

Gene Name

• ARSH

Ensembl ID

• ENST00000381130
• ENSP00000370522
• ENSG00000205667

Symbol

• sulfatase

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease	0.89
cellular component	0.63
protein domain	0.58
tissue sample	0.58
cell line	0.55

Protein Classes

PANTHER Classes

Protein / Hydrolase / Arylsulfatase H

DTO Classes

Protein / Enzyme / Hydrolase / Arylsulfatase H

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.61   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 130   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.61   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (56)

Explore Interacting Targets

1 – 10 of 56

• See Interactions on String-DB

SUMF1

Tbio

Family:  Enzyme

Novelty:  0.00954537

Score:  0.987

Data Source:  STRINGDB

SUMF2

Tbio

Family:  Enzyme

Novelty:  0.07551737

Score:  0.966

Data Source:  STRINGDB

ARSK

Tbio

Family:  Enzyme

Novelty:  0.11486213

Score:  0.947

Data Source:  STRINGDB

ARSB

Tbio

Family:  Enzyme

Novelty:  0.01044355

Score:  0.941

Data Source:  STRINGDB

ARSI

Tbio

Family:  Enzyme

Novelty:  0.04002595

Score:  0.941

Data Source:  STRINGDB

ARSJ

Tdark

Family:  Enzyme

Novelty:  0.00769596

Score:  0.932

Data Source:  STRINGDB

ARSG

Tbio

Family:  Enzyme

Novelty:  0.04412917

Score:  0.926

Data Source:  STRINGDB

ARSA

Tbio

Family:  Enzyme

Novelty:  0.00469851

Score:  0.924

Data Source:  STRINGDB

STS

Tchem

Family:  Enzyme

Novelty:  0.00324549

Score:  0.906

Data Source:  STRINGDB

GNS

Tbio

Family:  Enzyme

Novelty:  0.01528509

Score:  0.906

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (8)

Reactome (8)

Gamma carboxylation, hypusine formation and arylsulfatase activation (R-HSA-163841)

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5

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Gamma carboxylation, hypusine formation and arylsulfatase activation	39 targets	R-HSA-163841
Reactome	Glycosphingolipid metabolism	46 targets	R-HSA-1660662
Reactome	Metabolism	2112 targets	R-HSA-1430728
Reactome	Metabolism of lipids	740 targets	R-HSA-556833
Reactome	Metabolism of proteins	2050 targets	R-HSA-392499

Name	Explore in Pharos	Explore in Source
Gamma carboxylation, hypusine formation and arylsulfatase activation	39 targets	R-HSA-163841
Glycosphingolipid metabolism	46 targets	R-HSA-1660662
Metabolism	2112 targets	R-HSA-1430728
Metabolism of lipids	740 targets	R-HSA-556833
Metabolism of proteins	2050 targets	R-HSA-392499

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (4)

Functions (2)

Components (2)

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Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
arylsulfatase activity	Traceable Author Statement (TAS)	HGNC
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations ()

No disease associations found

GWAS Traits (3)

• Explore on Target Illumination GWAS Analytics (TIGA)

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1 – 3 of 3

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
sex hormone-binding globulin measurement	EFO_0004696	6	2	6		81.8
low density lipoprotein cholesterol measurement	EFO_0004611	1	1	1		77.1
body height	EFO_0004339	2	1	2		52.7

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 3 of 3

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
sex hormone-binding globulin measurement	EFO_0004696	6		81.8
low density lipoprotein cholesterol measurement	EFO_0004611	1		77.1
body height	EFO_0004339	2		52.7

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UniProt Keyword Find Similar Targets

No Header	No Header
Calcium
Complete proteome
Hydrolase
Membrane
Metal-binding
Reference proteome
Transmembrane
Transmembrane helix

GWAS Trait Find Similar Targets

No Header	No Header
body height
low density lipoprotein cholesterol measurement
sex hormone-binding globulin measurement

IDG Resources

No IDG generated resources found

Orthologs (5)

1 – 5 of 5

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	arylsulfatase family member H	VGNC:12187	465470
Dog	arylsulfatase family member H	VGNC:53705	491720
Horse	arylsulfatase family member H	VGNC:49443	100064719
Cow	arylsulfatase family member H	VGNC:50166	100336572
Platypus	arylsulfatase family member H		100083896

Species	Name	OMA	EggNOG	Inparanoid
Chimp	arylsulfatase family member H
Dog	arylsulfatase family member H
Horse	arylsulfatase family member H
Cow	arylsulfatase family member H
Platypus	arylsulfatase family member H

Publication Statistics

PubMed Score 25.61

PubMed score by year

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PubTator Score 604.51

PubTator score by year

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Related Publications

Text Mined References (1)

Items per page:

10

0 of 0

PMID	Year	Title