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Tbio
ARSH
Arylsulfatase H

Protein Summary
Description
Sulfatases, such as ARSH, hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans, and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of macromolecules (Sardiello et al., 2005 [PubMed 16174644]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000381130
  • ENSP00000370522
  • ENSG00000205667

Symbol
  • sulfatase
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease
0.89
cellular component
0.63
protein domain
0.58
tissue sample
0.58
cell line
0.55


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.61   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 130   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.61   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (56)
SUMF1
Tbio
Family:  Enzyme
Novelty:  0.00954537
Score:  0.987
Data Source:  STRINGDB
SUMF2
Tbio
Family:  Enzyme
Novelty:  0.07551737
Score:  0.966
Data Source:  STRINGDB
ARSK
Tbio
Family:  Enzyme
Novelty:  0.11486213
Score:  0.947
Data Source:  STRINGDB
ARSB
Tbio
Family:  Enzyme
Novelty:  0.01044355
Score:  0.941
Data Source:  STRINGDB
ARSI
Tbio
Family:  Enzyme
Novelty:  0.04002595
Score:  0.941
Data Source:  STRINGDB
ARSJ
Tdark
Family:  Enzyme
Novelty:  0.00769596
Score:  0.932
Data Source:  STRINGDB
ARSG
Tbio
Family:  Enzyme
Novelty:  0.04412917
Score:  0.926
Data Source:  STRINGDB
ARSA
Tbio
Family:  Enzyme
Novelty:  0.00469851
Score:  0.924
Data Source:  STRINGDB
STS
Tchem
Family:  Enzyme
Novelty:  0.00324549
Score:  0.906
Data Source:  STRINGDB
GNS
Tbio
Family:  Enzyme
Novelty:  0.01528509
Score:  0.906
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Gamma carboxylation, hypusine formation and arylsulfatase activation (R-HSA-163841)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gamma carboxylation, hypusine formation and arylsulfatase activation
Reactome
Glycosphingolipid metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Gamma carboxylation, hypusine formation and arylsulfatase activation
Glycosphingolipid metabolism
Metabolism
Metabolism of lipids
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
2
6
81.8
low density lipoprotein cholesterol measurement
1
1
1
77.1
body height
2
1
2
52.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
81.8
low density lipoprotein cholesterol measurement
1
77.1
body height
2
52.7
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
arylsulfatase family member H
VGNC:12187
465470
Dog
arylsulfatase family member H
VGNC:53705
491720
Horse
arylsulfatase family member H
VGNC:49443
100064719
Cow
arylsulfatase family member H
VGNC:50166
100336572
Platypus
arylsulfatase family member H
100083896
Species
Name
OMA
EggNOG
Inparanoid
Chimp
arylsulfatase family member H
Dog
arylsulfatase family member H
Horse
arylsulfatase family member H
Cow
arylsulfatase family member H
Platypus
arylsulfatase family member H
Publication Statistics
PubMed Score 25.61
PubMed score by year
PubTator Score 604.51
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title