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Tbio
ARSG
Arylsulfatase G

Protein Summary
Description
Displays arylsulfatase activity at acidic pH with pseudosubstrates, such as p-nitrocatechol sulfate and also, but with lower activity, p-nitrophenyl sulfate and 4-methylumbelliferyl sulfate. The protein encoded by this gene belongs to the sulfatase enzyme family. Sulfatases hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans, and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of macromolecules. This protein displays arylsulfatase activity at acidic pH, as is typical of lysosomal sulfatases, and has been shown to localize in the lysosomes. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000448504
  • ENSP00000407193
  • ENSG00000141337
  • ENST00000621439
  • ENSP00000480910

Symbol
  • KIAA1001
  • USH4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor
0.65
tissue sample
0.64
trait
0.61
protein domain
0.58
cellular component
0.56


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.01   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 147   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.01   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 147   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (60)
SUMF1
Tbio
Family:  Enzyme
Novelty:  0.00954537
p_int:  0.999694438
p_ni:  0.000305561
p_wrong:  1e-9
Score:  0.976
Data Source:  BioPlex,STRINGDB
YDJC
Tbio
Family:  Enzyme
Novelty:  0.19574858
p_int:  0.999232978
p_ni:  0.000057457
p_wrong:  0.000709565
Score:  0.187
Data Source:  BioPlex,STRINGDB
GSK3A
Tclin
Family:  Kinase
Novelty:  0.00925708
p_int:  0.997910093
p_ni:  0.000487303
p_wrong:  0.001602604
Score:  0.183
Data Source:  BioPlex,STRINGDB
TMEM214
Tdark
Novelty:  0.32604613
p_int:  0.988771852
p_ni:  0.011228148
Data Source:  BioPlex
PTPRK
Tbio
Family:  Enzyme
Novelty:  0.03149943
p_int:  0.983850479
p_ni:  0.016125288
p_wrong:  0.000024233
Score:  0.243
Data Source:  BioPlex,STRINGDB
MESD
Tbio
Novelty:  0.02639297
p_int:  0.977610868
p_ni:  0.022389084
p_wrong:  4.8e-8
Score:  0.173
Data Source:  BioPlex,STRINGDB
PSCA
Tbio
Novelty:  0.00323778
p_int:  0.969629946
p_ni:  0.030366885
p_wrong:  0.000003169
Data Source:  BioPlex
CTAGE5
Tbio
Novelty:  0.04516631
p_int:  0.966319572
p_ni:  0.033670182
p_wrong:  0.000010246
Data Source:  BioPlex
TUBA4A
Tchem
Novelty:  0.00820546
p_int:  0.953537838
p_ni:  0.046462162
Score:  0.15
Data Source:  BioPlex,STRINGDB
DPH1
Tbio
Novelty:  0.02296024
p_int:  0.945293379
p_ni:  0.054706621
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (9)
Gamma carboxylation, hypusine formation and arylsulfatase activation (R-HSA-163841)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gamma carboxylation, hypusine formation and arylsulfatase activation
Reactome
Glycosphingolipid metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Gamma carboxylation, hypusine formation and arylsulfatase activation
Glycosphingolipid metabolism
Metabolism
Metabolism of lipids
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
4
5
93
alkaline phosphatase measurement
2
2
1
6.9
89.8
reticulocyte count
4
3
4
83.5
reticulocyte measurement
3
3
3
82
glomerular filtration rate
3
3
3
70.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
5
93
alkaline phosphatase measurement
1
6.9
89.8
reticulocyte count
4
83.5
reticulocyte measurement
3
82
glomerular filtration rate
3
70.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
arylsulfatase G
VGNC:12030
454844
Mouse
MGI:1921258
74008
Rat
RGD:1306571
303631
Dog
arylsulfatase G
VGNC:51920
480460
Horse
arylsulfatase G
VGNC:49382
100062864
Species
Name
OMA
EggNOG
Inparanoid
Chimp
arylsulfatase G
Mouse
Rat
Dog
arylsulfatase G
Horse
arylsulfatase G
Publication Statistics
PubMed Score 25.01
PubMed score by year
PubTator Score 15.08
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title