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Tbio
ARSF
Arylsulfatase F

Protein Summary
Description
This gene is a member of the sulfatase family, and more specifically, the arylsulfatase subfamily. Members of the subfamily share similarity in sequence and splice sites, and are clustered together on chromosome X, suggesting that they are derived from recent gene duplication events. Sulfatases are essential for the correct composition of bone and cartilage matrix. The activity of this protein, unlike that of arylsulfatase E, is not inhibited by warfarin. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Jan 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359361
  • ENSP00000352319
  • ENSG00000062096
  • ENST00000381127
  • ENSP00000370519

Symbol
  • ASF
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.58
protein domain
0.58
cellular component
0.52
metabolite
0.45
pathway
0.42


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.56   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 176   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.56   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 176   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (32)
TRAP1
Tchem
Novelty:  0.03344189
p_int:  0.999999971
p_ni:  2.9e-8
Data Source:  BioPlex
SCYL3
Tbio
Family:  Kinase
Novelty:  0.13735583
p_int:  0.99963385
p_ni:  0.00036615
Data Source:  BioPlex
BRK1
Tbio
Novelty:  0.02289534
p_int:  0.99963018
p_ni:  0.00036982
Data Source:  BioPlex
FARSB
Tchem
Family:  Enzyme
Novelty:  0.09683467
p_int:  0.999022931
p_ni:  0.000977067
p_wrong:  2e-9
Data Source:  BioPlex
TBC1D22B
Tbio
Novelty:  0.49852962
p_int:  0.998923441
p_ni:  0.000002785
p_wrong:  0.001073774
Score:  0.188
Data Source:  BioPlex,STRINGDB
SUMF1
Tbio
Family:  Enzyme
Novelty:  0.00954537
Score:  0.97
Data Source:  STRINGDB
SUMF2
Tbio
Family:  Enzyme
Novelty:  0.07551737
Score:  0.947
Data Source:  STRINGDB
ARSB
Tbio
Family:  Enzyme
Novelty:  0.01044355
Score:  0.934
Data Source:  STRINGDB
ARSA
Tbio
Family:  Enzyme
Novelty:  0.00469851
Score:  0.919
Data Source:  STRINGDB
ARSK
Tbio
Family:  Enzyme
Novelty:  0.11486213
Score:  0.918
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Gamma carboxylation, hypusine formation and arylsulfatase activation (R-HSA-163841)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gamma carboxylation, hypusine formation and arylsulfatase activation
Reactome
Glycosphingolipid metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Gamma carboxylation, hypusine formation and arylsulfatase activation
Glycosphingolipid metabolism
Metabolism
Metabolism of lipids
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
2
1
2
52.7
sex hormone-binding globulin measurement
2
1
2
46.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
2
52.7
sex hormone-binding globulin measurement
2
46.1
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
arylsulfatase F
749091
Macaque
arylsulfatase F
705983
Dog
arylsulfatase F
VGNC:53704
609908
Horse
arylsulfatase F
VGNC:49490
100064771
Pig
arylsulfatase F-like
100621771
Species
Name
OMA
EggNOG
Inparanoid
Chimp
arylsulfatase F
Macaque
arylsulfatase F
Dog
arylsulfatase F
Horse
arylsulfatase F
Pig
arylsulfatase F-like
Publication Statistics
PubMed Score 8.56
PubMed score by year
PubTator Score 126.77
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title