Protein Summary
This gene is a member of the sulfatase family, and more specifically, the arylsulfatase subfamily. Members of the subfamily share similarity in sequence and splice sites, and are clustered together on chromosome X, suggesting that they are derived from recent gene duplication events. Sulfatases are essential for the correct composition of bone and cartilage matrix. The activity of this protein, unlike that of arylsulfatase E, is not inhibited by warfarin. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Jan 2011]
- ENST00000359361
- ENSP00000352319
- ENSG00000062096
- ENST00000381127
- ENSP00000370519
- ASF
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
cell line | 0.58 | ||
protein domain | 0.58 | ||
cellular component | 0.52 | ||
metabolite | 0.45 | ||
pathway | 0.42 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 8.56 (req: < 5)
Gene RIFs: 0 (req: <= 3)
Antibodies: 176 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 8.56 (req: >= 5)
Gene RIFs: 0 (req: > 3)
Antibodies: 176 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 2
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (32)
FARSB
Family: Enzyme
Novelty: 0.09683467
p_int: 0.999022931
p_ni: 0.000977067
p_wrong: 2e-9
Data Source: BioPlex
TBC1D22B
Novelty: 0.49852962
p_int: 0.998923441
p_ni: 0.000002785
p_wrong: 0.001073774
Score: 0.188
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (8)
Reactome (8)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Gamma carboxylation, hypusine formation and arylsulfatase activation | ||||
Reactome | Glycosphingolipid metabolism | ||||
Reactome | Metabolism | ||||
Reactome | Metabolism of lipids | ||||
Reactome | Metabolism of proteins | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Gamma carboxylation, hypusine formation and arylsulfatase activation | ||||
Glycosphingolipid metabolism | ||||
Metabolism | ||||
Metabolism of lipids | ||||
Metabolism of proteins | ||||
Viral Interactions (0)
Gene Ontology Terms (4)
Functions (2)
Components (2)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
body height | 2 | 1 | 2 | 52.7 | |||||
sex hormone-binding globulin measurement | 2 | 1 | 2 | 46.1 | |||||
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
body height | 2 | 52.7 | |||||
sex hormone-binding globulin measurement | 2 | 46.1 | |||||
Find similar targets by:
IDG Resources
Orthologs (6)
1 – 5 of 6
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | arylsulfatase F | 749091 | ||||||
Macaque | arylsulfatase F | 705983 | ||||||
Dog | arylsulfatase F | VGNC:53704 | 609908 | |||||
Horse | arylsulfatase F | VGNC:49490 | 100064771 | |||||
Pig | arylsulfatase F-like | 100621771 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | arylsulfatase F | |||||
Macaque | arylsulfatase F | |||||
Dog | arylsulfatase F | |||||
Horse | arylsulfatase F | |||||
Pig | arylsulfatase F-like | |||||
Publication Statistics
PubMed Score 8.56
PubMed score by year
PubTator Score 126.77
PubTator score by year
Related Publications
Text Mined References (11)
Items per page:
0 of 0
PMID | Year | Title |
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