Tbio ARSE Arylsulfatase E

Protein Summary

Description

May be essential for the correct composition of cartilage and bone matrix during development. Has no activity toward steroid sulfates. Arylsulfatase E is a member of the sulfatase family. It is glycosylated postranslationally and localized to the golgi apparatus. Sulfatases are essential for the correct composition of bone and cartilage matrix. X-linked chondrodysplasia punctata, a disease characterized by abnormalities in cartilage and bone development, has been linked to mutations in this gene. Alternative splicing results in multiple transcript variants. A pseudogene related to this gene is located on the Y chromosome. [provided by RefSeq, Sep 2013]

Uniprot Accession IDs

• P51690
• Q53FT2
• Q53FU8
• ASE

Gene Name

• ARSE

Ensembl ID

• ENST00000381134
• ENSP00000370526
• ENSG00000157399

Symbol

• ASE
• CDPX
• CDPX1
• CDPXR

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	0.76
cellular component	0.69
protein domain	0.58
tissue sample	0.58
cell line	0.5

Protein Classes

PANTHER Classes

Protein / Hydrolase / Arylsulfatase E

DTO Classes

Protein / Enzyme / Hydrolase / Arylsulfatase E

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 759.7   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 111   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 759.7   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 111   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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Target Illumination GWAS Analytics (TIGA)

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GENEVA

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GlyGen

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (64)

Explore Interacting Targets

1 – 10 of 64

• See Interactions on String-DB

ARSD

Tbio

Family:  Enzyme

Novelty:  0.00680724

p_int:  0.999999858

p_wrong:  1.42e-7

Score:  0.904

Data Source:  BioPlex,STRINGDB

SQOR

Tchem

Family:  Enzyme

Novelty:  0.00291617

p_int:  0.999995185

p_ni:  0.000004815

Data Source:  BioPlex

NIN

Tbio

Novelty:  0.01312714

p_int:  0.999995124

p_ni:  0.000002555

p_wrong:  0.000002322

Data Source:  BioPlex

SUMF1

Tbio

Family:  Enzyme

Novelty:  0.00954537

p_int:  0.999950965

p_ni:  0.000049035

Score:  0.968

Data Source:  BioPlex,STRINGDB

ZDHHC17

Tbio

Family:  Enzyme

Novelty:  0.03288707

p_int:  0.999613396

p_ni:  0.000386604

Data Source:  BioPlex

SELENOT

Tbio

Novelty:  0.02480242

p_int:  0.998909521

p_ni:  0.000723361

p_wrong:  0.000367118

Data Source:  BioPlex

ZDHHC13

Tbio

Family:  Enzyme

Novelty:  0.17442533

p_int:  0.998702505

p_ni:  0.001297495

Data Source:  BioPlex

TMEM39B

Tdark

Novelty:  3.99024108

p_int:  0.980021975

p_ni:  0.016532151

p_wrong:  0.003445875

Data Source:  BioPlex

FZD2

Tbio

Family:  GPCR

Novelty:  0.00774893

p_int:  0.951674203

p_ni:  0.03412066

p_wrong:  0.014205137

Data Source:  BioPlex

DSTYK

Tchem

Family:  Kinase

Novelty:  0.12049855

p_int:  0.949457499

p_ni:  0.050532885

p_wrong:  0.000009616

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (45)

Reactome (8)

WikiPathways (37)

Gamma carboxylation, hypusine formation and arylsulfatase activation (R-HSA-163841)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Gamma carboxylation, hypusine formation and arylsulfatase activation	39 targets	R-HSA-163841
Reactome	Glycosphingolipid metabolism	46 targets	R-HSA-1660662
Reactome	Metabolism	2112 targets	R-HSA-1430728
Reactome	Metabolism of lipids	740 targets	R-HSA-556833
Reactome	Metabolism of proteins	2050 targets	R-HSA-392499

Name	Explore in Pharos	Explore in Source
Gamma carboxylation, hypusine formation and arylsulfatase activation	39 targets	R-HSA-163841
Glycosphingolipid metabolism	46 targets	R-HSA-1660662
Metabolism	2112 targets	R-HSA-1430728
Metabolism of lipids	740 targets	R-HSA-556833
Metabolism of proteins	2050 targets	R-HSA-392499

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (7)

Functions (2)

Components (4)

Processes (1)

Find Similar Targets

Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
arylsulfatase activity	Traceable Author Statement (TAS)	ProtInc
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations ()

No disease associations found

GWAS Traits (3)

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1 – 3 of 3

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
sex hormone-binding globulin measurement	EFO_0004696	6	2	6		81.8
low density lipoprotein cholesterol measurement	EFO_0004611	1	1	1		77.1
body height	EFO_0004339	2	1	2		52.7

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 3 of 3

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
sex hormone-binding globulin measurement	EFO_0004696	6		81.8
low density lipoprotein cholesterol measurement	EFO_0004611	1		77.1
body height	EFO_0004339	2		52.7

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UniProt Keyword Find Similar Targets

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Calcium
Complete proteome
Disease mutation
Glycoprotein
Golgi apparatus
Hydrolase
Metal-binding
Reference proteome
Signal

GWAS Trait Find Similar Targets

No Header	No Header
body height
low density lipoprotein cholesterol measurement
sex hormone-binding globulin measurement

IDG Resources

No IDG generated resources found

Orthologs (8)

1 – 5 of 8

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Macaque	arylsulfatase E (chondrodysplasia punctata 1)		720575
Rat	arylsulfatase E	RGD:1304917	310326
Dog	arylsulfatase E (chondrodysplasia punctata 1)		491719
Horse	arylsulfatase E (chondrodysplasia punctata 1)		100064693
Cow	arylsulfatase E (chondrodysplasia punctata 1)		505899

Species	Name	OMA	EggNOG	Inparanoid
Macaque	arylsulfatase E (chondrodysplasia punctata 1)
Rat	arylsulfatase E
Dog	arylsulfatase E (chondrodysplasia punctata 1)
Horse	arylsulfatase E (chondrodysplasia punctata 1)
Cow	arylsulfatase E (chondrodysplasia punctata 1)

Publication Statistics

PubMed Score 759.70

PubMed score by year

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PubTator Score 362.24

PubTator score by year

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Related Publications

Text Mined References (22)

GeneRif Annotations (3)

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PMID	Year	Title