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Tbio
ARSE
Arylsulfatase E

Protein Summary
Description
May be essential for the correct composition of cartilage and bone matrix during development. Has no activity toward steroid sulfates. Arylsulfatase E is a member of the sulfatase family. It is glycosylated postranslationally and localized to the golgi apparatus. Sulfatases are essential for the correct composition of bone and cartilage matrix. X-linked chondrodysplasia punctata, a disease characterized by abnormalities in cartilage and bone development, has been linked to mutations in this gene. Alternative splicing results in multiple transcript variants. A pseudogene related to this gene is located on the Y chromosome. [provided by RefSeq, Sep 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000381134
  • ENSP00000370526
  • ENSG00000157399

Symbol
  • ASE
  • CDPX
  • CDPX1
  • CDPXR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.76
cellular component
0.69
protein domain
0.58
tissue sample
0.58
cell line
0.5


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 759.7   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 111   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 759.7   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 111   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (64)
ARSD
Tbio
Family:  Enzyme
Novelty:  0.00680724
p_int:  0.999999858
p_wrong:  1.42e-7
Score:  0.904
Data Source:  BioPlex,STRINGDB
SQOR
Tchem
Family:  Enzyme
Novelty:  0.00291617
p_int:  0.999995185
p_ni:  0.000004815
Data Source:  BioPlex
NIN
Tbio
Novelty:  0.01312714
p_int:  0.999995124
p_ni:  0.000002555
p_wrong:  0.000002322
Data Source:  BioPlex
SUMF1
Tbio
Family:  Enzyme
Novelty:  0.00954537
p_int:  0.999950965
p_ni:  0.000049035
Score:  0.968
Data Source:  BioPlex,STRINGDB
ZDHHC17
Tbio
Family:  Enzyme
Novelty:  0.03288707
p_int:  0.999613396
p_ni:  0.000386604
Data Source:  BioPlex
SELENOT
Tbio
Novelty:  0.02480242
p_int:  0.998909521
p_ni:  0.000723361
p_wrong:  0.000367118
Data Source:  BioPlex
ZDHHC13
Tbio
Family:  Enzyme
Novelty:  0.17442533
p_int:  0.998702505
p_ni:  0.001297495
Data Source:  BioPlex
TMEM39B
Tdark
Novelty:  3.99024108
p_int:  0.980021975
p_ni:  0.016532151
p_wrong:  0.003445875
Data Source:  BioPlex
FZD2
Tbio
Family:  GPCR
Novelty:  0.00774893
p_int:  0.951674203
p_ni:  0.03412066
p_wrong:  0.014205137
Data Source:  BioPlex
DSTYK
Tchem
Family:  Kinase
Novelty:  0.12049855
p_int:  0.949457499
p_ni:  0.050532885
p_wrong:  0.000009616
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (45)
Gamma carboxylation, hypusine formation and arylsulfatase activation (R-HSA-163841)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gamma carboxylation, hypusine formation and arylsulfatase activation
Reactome
Glycosphingolipid metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Gamma carboxylation, hypusine formation and arylsulfatase activation
Glycosphingolipid metabolism
Metabolism
Metabolism of lipids
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
2
6
81.8
low density lipoprotein cholesterol measurement
1
1
1
77.1
body height
2
1
2
52.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
81.8
low density lipoprotein cholesterol measurement
1
77.1
body height
2
52.7
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
arylsulfatase E (chondrodysplasia punctata 1)
720575
Rat
RGD:1304917
310326
Dog
arylsulfatase E (chondrodysplasia punctata 1)
491719
Horse
arylsulfatase E (chondrodysplasia punctata 1)
100064693
Cow
arylsulfatase E (chondrodysplasia punctata 1)
505899
Species
Name
OMA
EggNOG
Inparanoid
Macaque
arylsulfatase E (chondrodysplasia punctata 1)
Rat
Dog
arylsulfatase E (chondrodysplasia punctata 1)
Horse
arylsulfatase E (chondrodysplasia punctata 1)
Cow
arylsulfatase E (chondrodysplasia punctata 1)
Publication Statistics
PubMed Score 759.70
PubMed score by year
PubTator Score 362.24
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title