Protein Summary
May be essential for the correct composition of cartilage and bone matrix during development. Has no activity toward steroid sulfates. Arylsulfatase E is a member of the sulfatase family. It is glycosylated postranslationally and localized to the golgi apparatus. Sulfatases are essential for the correct composition of bone and cartilage matrix. X-linked chondrodysplasia punctata, a disease characterized by abnormalities in cartilage and bone development, has been linked to mutations in this gene. Alternative splicing results in multiple transcript variants. A pseudogene related to this gene is located on the Y chromosome. [provided by RefSeq, Sep 2013]
- ENST00000381134
- ENSP00000370526
- ENSG00000157399
- ASE
- CDPX
- CDPX1
- CDPXR
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
co-expressed gene | 0.76 | ||
cellular component | 0.69 | ||
protein domain | 0.58 | ||
tissue sample | 0.58 | ||
cell line | 0.5 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 759.7 (req: < 5)
Gene RIFs: 3 (req: <= 3)
Antibodies: 111 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 759.7 (req: >= 5)
Gene RIFs: 3 (req: > 3)
Antibodies: 111 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (64)
ARSD
Family: Enzyme
Novelty: 0.00680724
p_int: 0.999999858
p_wrong: 1.42e-7
Score: 0.904
Data Source: BioPlex,STRINGDB
SQOR
Family: Enzyme
Novelty: 0.00291617
p_int: 0.999995185
p_ni: 0.000004815
Data Source: BioPlex
NIN
Novelty: 0.01312714
p_int: 0.999995124
p_ni: 0.000002555
p_wrong: 0.000002322
Data Source: BioPlex
SUMF1
Family: Enzyme
Novelty: 0.00954537
p_int: 0.999950965
p_ni: 0.000049035
Score: 0.968
Data Source: BioPlex,STRINGDB
ZDHHC17
Family: Enzyme
Novelty: 0.03288707
p_int: 0.999613396
p_ni: 0.000386604
Data Source: BioPlex
SELENOT
Novelty: 0.02480242
p_int: 0.998909521
p_ni: 0.000723361
p_wrong: 0.000367118
Data Source: BioPlex
ZDHHC13
Family: Enzyme
Novelty: 0.17442533
p_int: 0.998702505
p_ni: 0.001297495
Data Source: BioPlex
TMEM39B
Novelty: 3.99024108
p_int: 0.980021975
p_ni: 0.016532151
p_wrong: 0.003445875
Data Source: BioPlex
FZD2
Family: GPCR
Novelty: 0.00774893
p_int: 0.951674203
p_ni: 0.03412066
p_wrong: 0.014205137
Data Source: BioPlex
DSTYK
Family: Kinase
Novelty: 0.12049855
p_int: 0.949457499
p_ni: 0.050532885
p_wrong: 0.000009616
Data Source: BioPlex
Nearest Tclin Targets
Pathways (45)
Reactome (8)
WikiPathways (37)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Gamma carboxylation, hypusine formation and arylsulfatase activation | ||||
Reactome | Glycosphingolipid metabolism | ||||
Reactome | Metabolism | ||||
Reactome | Metabolism of lipids | ||||
Reactome | Metabolism of proteins | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Gamma carboxylation, hypusine formation and arylsulfatase activation | ||||
Glycosphingolipid metabolism | ||||
Metabolism | ||||
Metabolism of lipids | ||||
Metabolism of proteins | ||||
Viral Interactions (0)
Gene Ontology Terms (7)
Functions (2)
Components (4)
Processes (1)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
sex hormone-binding globulin measurement | 6 | 2 | 6 | 81.8 | |||||
low density lipoprotein cholesterol measurement | 1 | 1 | 1 | 77.1 | |||||
body height | 2 | 1 | 2 | 52.7 | |||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
sex hormone-binding globulin measurement | 6 | 81.8 | |||||
low density lipoprotein cholesterol measurement | 1 | 77.1 | |||||
body height | 2 | 52.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Macaque | arylsulfatase E (chondrodysplasia punctata 1) | 720575 | ||||||
Rat | RGD:1304917 | 310326 | ||||||
Dog | arylsulfatase E (chondrodysplasia punctata 1) | 491719 | ||||||
Horse | arylsulfatase E (chondrodysplasia punctata 1) | 100064693 | ||||||
Cow | arylsulfatase E (chondrodysplasia punctata 1) | 505899 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Macaque | arylsulfatase E (chondrodysplasia punctata 1) | |||||
Rat | ||||||
Dog | arylsulfatase E (chondrodysplasia punctata 1) | |||||
Horse | arylsulfatase E (chondrodysplasia punctata 1) | |||||
Cow | arylsulfatase E (chondrodysplasia punctata 1) | |||||
Publication Statistics
PubMed Score 759.70
PubMed score by year
PubTator Score 362.24
PubTator score by year
Related Publications
Text Mined References (22)
GeneRif Annotations (3)
Items per page:
0 of 0
PMID | Year | Title |
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