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Tbio
ARSD
Arylsulfatase D

Protein Summary
Description
The protein encoded by this gene is a member of the sulfatase family. Sulfatases are essential for the correct composition of bone and cartilage matrix. The encoded protein is postranslationally glycosylated and localized to the lysosome. This gene is located within a cluster of similar arylsulfatase genes on chromosome X. A related pseudogene has been identified in the pseudoautosomal region of chromosome Y. [provided by RefSeq, Jul 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000381154
  • ENSP00000370546
  • ENSG00000006756

Symbol
  • ASD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.76
cell type or tissue
0.7
tissue sample
0.63
microRNA
0.62
protein domain
0.58


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 147.17   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 151   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 147.17   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 151   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (26)
ARSE
Tbio
Family:  Enzyme
Novelty:  0.00151862
p_int:  0.999999858
p_wrong:  1.42e-7
Score:  0.904
Data Source:  BioPlex,STRINGDB
SUMF1
Tbio
Family:  Enzyme
Novelty:  0.00954537
Score:  0.968
Data Source:  STRINGDB
SUMF2
Tbio
Family:  Enzyme
Novelty:  0.07551737
Score:  0.951
Data Source:  STRINGDB
ARSB
Tbio
Family:  Enzyme
Novelty:  0.01044355
Score:  0.937
Data Source:  STRINGDB
ARSA
Tbio
Family:  Enzyme
Novelty:  0.00469851
Score:  0.922
Data Source:  STRINGDB
ARSJ
Tdark
Family:  Enzyme
Novelty:  0.00769596
Score:  0.921
Data Source:  STRINGDB
ARSI
Tbio
Family:  Enzyme
Novelty:  0.04002595
Score:  0.92
Data Source:  STRINGDB
ARSK
Tbio
Family:  Enzyme
Novelty:  0.11486213
Score:  0.918
Data Source:  STRINGDB
ARSF
Tbio
Family:  Enzyme
Novelty:  0.13109678
Score:  0.915
Data Source:  STRINGDB
ARSG
Tbio
Family:  Enzyme
Novelty:  0.04412917
Score:  0.909
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (9)
Gamma carboxylation, hypusine formation and arylsulfatase activation (R-HSA-163841)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gamma carboxylation, hypusine formation and arylsulfatase activation
Reactome
Glycosphingolipid metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Gamma carboxylation, hypusine formation and arylsulfatase activation
Glycosphingolipid metabolism
Metabolism
Metabolism of lipids
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
2
6
81.8
low density lipoprotein cholesterol measurement
1
1
1
77.1
body height
2
1
2
52.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
81.8
low density lipoprotein cholesterol measurement
1
77.1
body height
2
52.7
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
arylsulfatase D
704070
Dog
arylsulfatase D
VGNC:53702
491718
Platypus
arylsulfatase D-like
100083853
Chicken
arylsulfatase family, member H
CGNC:49125
378798
Anole lizard
arylsulfatase H
100554941
Species
Name
OMA
EggNOG
Inparanoid
Macaque
arylsulfatase D
Dog
arylsulfatase D
Platypus
arylsulfatase D-like
Chicken
arylsulfatase family, member H
Anole lizard
arylsulfatase H
Publication Statistics
PubMed Score 147.17
PubMed score by year
PubTator Score 82.44
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title