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Tbio
ARSA
Arylsulfatase A

Protein Summary
Description
Hydrolyzes cerebroside sulfate. The protein encoded by this gene hydrolyzes cerebroside sulfate to cerebroside and sulfate. Defects in this gene lead to metachromatic leucodystrophy (MLD), a progressive demyelination disease which results in a variety of neurological symptoms and ultimately death. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Dec 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000453344
  • ENSP00000412542
  • ENSG00000100299

Symbol
  • ASA
  • MLD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.91
cellular component
0.8
virus perturbation
0.68
PubMedID
0.66
transcription factor binding site profile
0.64


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 209.17   (req: < 5)
Gene RIFs: 44   (req: <= 3)
Antibodies: 413   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 209.17   (req: >= 5)
Gene RIFs: 44   (req: > 3)
Antibodies: 413   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (156)
SUMF1
Tbio
Family:  Enzyme
Novelty:  0.00954537
p_int:  0.999988965
p_ni:  0.000011011
p_wrong:  2.3e-8
Score:  0.98
Data Source:  BioPlex,STRINGDB
ZBTB43
Tdark
Family:  TF
Novelty:  0.35735342
p_int:  0.999937654
p_ni:  0.000048507
p_wrong:  0.000013839
Score:  0.519
Data Source:  BioPlex,STRINGDB
GALNS
Tbio
Family:  Enzyme
Novelty:  0.00510529
p_int:  0.999627991
p_ni:  0.000372009
Score:  0.977
Data Source:  BioPlex,STRINGDB
MESD
Tbio
Novelty:  0.02639297
p_int:  0.997299593
p_ni:  0.002700378
p_wrong:  2.9e-8
Score:  0.196
Data Source:  BioPlex,STRINGDB
NDUFV3
Tclin
Family:  Enzyme
Novelty:  0.15352039
p_int:  0.984199916
p_ni:  0.015800084
Data Source:  BioPlex
PTPRK
Tbio
Family:  Enzyme
Novelty:  0.03149943
p_int:  0.937468672
p_ni:  0.062531328
Score:  0.169
Data Source:  BioPlex,STRINGDB
PLAUR
Tchem
Family:  Enzyme
Novelty:  0.00087642
p_int:  0.907428531
p_ni:  0.092571469
Score:  0.198
Data Source:  BioPlex,STRINGDB
SCGB1D1
Tbio
Novelty:  0.04199997
p_int:  0.855766058
p_ni:  0.144233942
Score:  0.166
Data Source:  BioPlex,STRINGDB
DNASE2B
Tbio
Family:  Enzyme
Novelty:  0.02506932
p_int:  0.843844893
p_ni:  0.156155104
p_wrong:  3e-9
Score:  0.22
Data Source:  BioPlex,STRINGDB
TMEM25
Tdark
Novelty:  0.35505784
p_int:  0.830738787
p_ni:  0.169261206
p_wrong:  8e-9
Data Source:  BioPlex
Pathways (16)
Gamma carboxylation, hypusine formation and arylsulfatase activation (R-HSA-163841)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gamma carboxylation, hypusine formation and arylsulfatase activation
Reactome
Glycosphingolipid metabolism
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Metabolism
Name
Explore in Pharos
Explore in Source
Gamma carboxylation, hypusine formation and arylsulfatase activation
Glycosphingolipid metabolism
Immune System
Innate Immune System
Metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (28)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
5
6
7
98.8
mean reticulocyte volume
1
3
3
95.9
red blood cell distribution width
4
4
4
95.6
mean corpuscular hemoglobin
3
3
3
94.6
mean corpuscular hemoglobin concentration
2
2
2
91.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
7
98.8
mean reticulocyte volume
3
95.9
red blood cell distribution width
4
95.6
mean corpuscular hemoglobin
3
94.6
mean corpuscular hemoglobin concentration
2
91.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
arylsulfatase A
VGNC:12816
458946
Macaque
arylsulfatase A
716500
Mouse
MGI:88077
11883
Rat
RGD:1310381
315222
Dog
arylsulfatase A
474457
Species
Name
OMA
EggNOG
Inparanoid
Chimp
arylsulfatase A
Macaque
arylsulfatase A
Mouse
Rat
Dog
arylsulfatase A
Publication Statistics
PubMed Score 209.17
PubMed score by year
PubTator Score 687.57
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title